Abstract
Avascular necrosis of the femoral head is one of the common problems in orthopedic practice in Taiwan. The subchondral bone loses its blood supply which weakens its biomechanical support. Steroid overuse is one of many possible etiologies in reducing blood flow to the femoral head. Laser Doppler velocimeter is a precise monitor of regional blood flow of bone which is expressed in perfusion units (PU). In the control group the rabbits were injected with normal saline and there were no statistical differences between blood flow to the right hip (39.26±5.64 PU) and left hip (38.58±4.35 PU). In group B a weekly injection of methylprednisolone into rabbits for 6 weeks demonstrated the reduction of blood flow of femoral head (24.74±3.13 PU) by the laser Doppler velocimeter. The flow decreased further (15.93±2.33 PU) by 12 weeks of steroid treatment. In group C after a weekly injection of steroid for 6 weeks the flow became 31.63±4.79 PU. The steroid was then discontinued for 3 weeks and the flow was 34.6±1.34 PU. In group D the blood flow was 25.89±4.01 PU after 6 weeks of steroid treatment and we stopped the steroid for 6 weeks, the blood flow became 29.86±2.59 PU. The merit of our experiment established a model of study in avascular necrosis of the femoral head in rabbits.
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References
Bassett GS, Apel DM, Wintersteen VG, Tolo VT. Measurement of femoral head microcirculation by laser Doppler flowmetry. J Pediatr Orthop 11:307–313;1991.
Fisher DE, Bickel WH, Holley KE, Ellefson RD. Corticosteroid-induced aseptic necrosis. II. Experimental study. Clin Orthop 84:200–206;1972.
Gebuhr P, Jorgensen JP, Vollmer-Larsen B, Nielsen SL, Alsbjorn J. Estimation of amputation level with a laser Doppler flowmeter. J Bone Joint Surg 71:514–517;1989.
Glimcher MJ, Kenzora JE. The biology of osteonecrosis of the human femoral head and its clinical implications. 2. The pathological changes in the femoral head as an organ and in the hip joint. Clin Orthop 139:283–312;1979.
Haajanen J, Sarrinen O, Laasonen L, Kuhlback B, Edgren J, Slatis P. Steroid treatment and aseptic necrosis of the femoral head in renal transplant recipients. Transplant Proc 16:1316–1319;1984.
Hallock GG. Preliminary assessment of laser Doppler flowmetry for determining timing of division of the cross-finger flap. J Hand Surg 15A:898–901;1990.
Hou SM, Seaber AV, Urbaniak JR. Relief of blood-induced arterial vasospasm by pharmacologic solutions. J Reconstr Microsurg 3:147–151;1987.
Hou SM, Seaber AV, Urbaniak JR. Blood-induced arterial segmental spasm. J Reconstr Microsurg 3:29–31;1986.
Notzli HP, Swiontkowski MF, Thaxter ST, Carpenter III GK, Wyatt R. Laser Doppler flowmetry for bone blood flow measurements: Helium-neon laser light attenuation and depth of perfusion assessment. J Orthop Res 7:413–424;1989.
Rich H, Gomez-Castresana F, Cabranes JA, Almoguera I, Lopez Duran L, Matute JA. Increased blood cortisol in alcoholic patients with aseptic necrosis of the femoral head. Calcif Tissue Int 37:585–587;1985.
Saito S, Inoue A, Ono K. Intramedullary haemorrhage as a possible cause of avascular necrosis of the femoral head. J Bone Joint Surg 69:346–351;1987.
Shih CH, Yang WE, Lee ZL, Kao YL, Hsueh S, Wei JS. Effect of long-term alcohol ingestion on the femoral head of rabbit. J Formosan Med Assoc 90:443–447;1991.
Solomon L. Drug-induced arthropathy and necrosis of the femoral head. J Bone Joint Surg 55:246–261;1973.
Stern MD, Lappe D, Bowen PD, Chimosky JE, Holloway GA, Keiser HR, Bowman RL. Continuous measurement of tissue blood flow by laser Doppler spectroscopy. Am J Physiol 232:H441-H448;1977.
Swiontkowski M, Tepic S, Ganz R, Perren SM. Laser Doppler flowmetry for measurement of femoral head blood flow. Helv Chir Acta 53:55–59;1986.
Swiontkowski MF, Tepic S, Perren SM, Moor R, Ganz R, Rahn BA. Laser Doppler flowmetry for bone blood flow measurement: Correlation with microsphere estimates and evaluation of the effect of intracapsular pressure on femoral head blood flow. J Orthop Res 4:362–371;1986.
Vegter J, Klopper PJ. Effect of intracapsular hyperpressure on femoral head blood flow. Laser Doppler flowmetry in dogs. Acta Orthop Scand 62:337–341;1991.
Wang GJ, Sweet DE, Reger SI, Thompson RC. Fat-cell changes as a mechanism of avascular necrosis of the femoral head in cortisone-treated rabbits. J Bone Joint Surg 59:729–735;1977.
Wang GJ, Dugham SS, Reger SI, Stamp WG. The effect of core decompression on femoral head blood flow in steroid-induced avascular necrosis of the femoral head. J Bone Joint Surg 67:121–124;1985.
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Hou, S.M., Liu, T.K. & Kao, M.C. Corticosteroid reduces blood flow to femoral heads in rabbits. J Biomed Sci 1, 61–64 (1993). https://doi.org/10.1007/BF02258341
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DOI: https://doi.org/10.1007/BF02258341