Summary
Copper(II) complexes of a large number of 2-acetylpyridine 4N-alkyl thiosemicarbazones were prepared and characterized. I.r., electronic and e.s.r. spectra of the complexes, as well as 1H and 13C n.m.r. spectra of the thiosemicarbazones, were obtained. Both the thiosemicarbazones and their complexes show either modest or no growth inhibitory activity against Aspergillus niger, but many have considerable activity against Paecilomyces variotii. There is a relationship between the antifungal activity and size of the 4N-substituent for both the thiosemicarbazones and their copper(II) complexes.
Similar content being viewed by others
References
D. X. West and N. C. Lewis, Transition Met. Chem., 12, 365 (1987).
D. X. West, C. S. Carlson, A. C. Whyte and A. E. Liberta, Transition Met. Chem., 15, 43 (1990).
D. X. West, R. D. Profilet and J. L. Hines, Transition Met. Chem., 13, 467 (1988).
D. X. West, B. L. Mokijewski, H. Gebremedhin and T. J. Romack, Transition Met. Chem., 17, 384 (1992).
A. E. Liberta and D. X. West, BioMetals, 5, 121 (1992).
J. P. Scovill, Phosph. Sulf. Sillic., 60, 15 (1991).
D. X. West, C. S. Carlson, A. E. Liberta, J. N. Albert and C. R. Daniel, Transition Met. Chem., 15, 341 (1990).
D. X. West, C. S. Carlson, K. J. Bouck and A. E. Liberta, Transition Met. Chem., 16, 271 (1991).
D. X. West, P. M. Ahrweiler, G. Ertem, J. P. Scovill, D. L. Klayman, J. L. Flippen-Anderson, R. Gilardi, C. George and L. K. Pannell, Transition Met. Chem., 10, 264 (1985).
K. R. Koch, J. Coord. Chem., 22, 289 (1991).
Y. K. Bhoon, S. Mitra, J. P. Scovill and D. L. Klayman, J. Med. Chem., 7, 264 (1982); Y. K. Bhoon, J. P. Scovill, and D. L. Klayman, Ind. J. Chem., 22A, 267 (1983); D. X. West, R. M. Makeever, J. P. Scovill and D. L. Klayman, Polyhedron, 3, 947 (1984); Y. K. Bhoon, D. L. Klayman and J. P. Scovill, Spectrochim. Acta, 40A, 691 (1984); S. K. Jain, B. S. Garg, Y. K. Bhoon, D. L. Klayman and J. P. Scovill, Spectrochim. Acta, 41A, 407 (1985); S. K.Jain, B. S. Garg and Y. K. Bhoon, Spectrochim. Acta, 42A, 959 (1986); D. X. West, J. P. Scovill, J. V. Silverton and A. Bavoso, Transition Met. Chem., 11,123 (1986); B. S. Garg, M. R. P. Kurup, S. K. Jain and Y. K. Bhoon, Transition Met. Chem., 13, 247 (1988); D. X. West and N. C. Lewis, Transition Met. Chem., 13, 277 (1988); D. X. West and D. S. Galloway, Transition Met. Chem., 13, 410 (1988); D. X. West, D. S. Galloway and D. A. Case, Transition Met. Chem., 13, 415 (1988); D. X. West, C. S. Carlson, C. P. Galloway, A. E. Liberia and C. R. Daniel, Transition Met. Chem., 15, 91 (1990).
D. X. West, S. B. Padhye and P. B. Sonawane, Struct. Bond., 76, 1 (1991).
J. Kohoul, M. Kabesova, M. Hvaslijova and J. Gazo, Coll. Czech. Chem. Comm., 43, 379 (1978); J. Kohoul, M. Hvastijova, J. Gazo and M. Nadvornik, Inorg. Chim. Acta, 14, 1151 (1984).
M. Biddau, M. Massacesi, R. Pinna and G. Ponticelli, Transition Met. Chem., 3, 153 (1978); M. H. Sonar and A. S. R. Murty, J. Inorg. Nucl. Chem., 42, 815 (1980); G. DeVoto, M. Massacesi, R. Pinna and G. Ponticelli, Spectrochim. Acta, 38A, 725 (1982).
P. L. Dedert, J. S. Thompson, J. A. Ibers and T. J. Marks, Inorg. Chem., 21, 969 (1982).
E. Ainscough, A. M. Brodie and N. G. Larsen, Inorg. Chim. Acta, 60, 25 (1982); L. Soto, A. Sancho and J. Borras, Synth. React. Inorg. Met.-Org. Chem., 16, 595 (1986).
M. Suzuki, H. Kanatomi, Y. Demura and I. Murase, Bull. Chem. Soc. Jpn, 57, 1003 (1984).
D. X. West, D. L. Huffman, J. S. Saleda and A. E. Liberta, Transition Met. Chem., 16, 565 (1991).
D. X. West, S. L. Dietrich, I. Thientanavanich, C. A. Brown and Anthony E. Liberta, Transition Met. Chem., in press.
R. Butcher, H. Gebremedhin and D. X. West, unpublished observations.
A. S. Kumbhar, S. B. Padhye, D. X. West and A. E. Liberta, Transition Met. Chem., 16, 271 (1991); A. S. Kumbhar, S. B. Padhye, D. X. West and A. E. Liberta, Transition Met. Chem., 17, 247 (1992).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
West, D.X., Gebremedhin, H., Romack, T.J. et al. Spectral and biological studies of copper(II) complexes of 2-acetyl-pyridine thiosemicarbazones with bulky 4N-substituents. Transition Met Chem 19, 426–431 (1994). https://doi.org/10.1007/BF00139320
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00139320