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Comparative bioavailability study of two brands of prazosin-containing tablets in healthy volunteers

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Abstract

The bioavailability of two prazosin formulations was studied in 12 healthy volunteers. 1 Subject left the study. Based on the statistical tests of the pharmacokinetic parameters of prazosin in 11 volunteers, such ast 1/2,C max,t max and AUC, it could be concluded that both preparations had comparable bioavailabilities.

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Authors and Affiliations

  1. Farma Research BV, P.O. Box 28, 5370, AA Ravenstein, the Netherlands

    P. J. M. Guelen, T. J. Janssen & M. H. Lam

  2. Department of Clinical Pharmacy, University Hospital Nijmegen, P.O. Box 9101, 6500, HB Nijmegen, the Netherlands

    T. B. Vree

  3. Farmaver BV, Handelsdwarsstraat 5, 6905, DJ Zevenaar, the Netherlands

    P. S. Exler

Authors
  1. P. J. M. Guelen
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  2. T. J. Janssen
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  3. M. H. Lam
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  4. T. B. Vree
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  5. P. S. Exler
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Guelen, P.J.M., Janssen, T.J., Lam, M.H. et al. Comparative bioavailability study of two brands of prazosin-containing tablets in healthy volunteers. Pharmaceutisch Weekblad Scientific Edition 12, 184–187 (1990). https://doi.org/10.1007/BF01980043

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  • DOI: https://doi.org/10.1007/BF01980043

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