Abstract
A comparative study of two groups of patients with paracoccidioidomycosis was carried out with the objective of comparing the evolutionary serologic, clinical and radiologic results after 6, 12, 15 and 18 months of treatment with ketoconazole (22 patients) or amphotericin B plus sulfonamides (32 patients). The serologic data analyzed as a whole showed a tendency to sharper drops in antibody titers in the patients treated with ketoconazole. Clinically patients treated with ketoconazole fared better but the differences were not statistically significant. No statistical difference was detected between groups in terms of the results of radiologic evolution.
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Cucé, L. C., E. L. Wroclawski & S. A. P. Sampaio, 1980. Treatment of paracoccidioidomycosis, candidiasis, chromomycosis, lobomycosis, and mycetoma with ketoconazole. Intern. J. Dermatol. 19: 405–408.
Cucé, L. C, E. L. Wroclawski & S. A. P. Sampaio, 1981. Treatment of paracoccidioidomycosis with ketoconazole. Rev. Inst. Med. trop. S. Paulo 23: 82–85.
De Felice, R., D. Y. Johnson & J. N. Galgiani, 1981. Gynecomastia with ketoconazole. Antimicrob. Agents Chemother. 19: 1073–1074.
Del Negro, G., 1982. Ketoconazole in paracoccidioidomycosis. A long-term therapy study with prolonged follow-up. Rev. Inst. Med. trop. S. Paulo 24: 27–39.
Dismukes, W. E., A. E. Stamm, J. R. Graybill, P. D. Craven, D. A. Stevens, R. L. Stiller, G. A. Sarosi, G. Medoff, C. R. Gregg, H. A. Gallis, B. T. Fields Jr., L. R. Marier, T. A. Kerkering, L. G. Kaplowitz, C. Bowles & S. Shadomy, 1983. Treatment of systemic mycosis with ketoconazole: emphasis on toxicity and clinical response in 52 patients. Ann. In. Med. 98: 13–20.
Franco, M. F., C. Fava Netto & L. G. Chamma, 1973. Reação de imunofluorescência indireta para o diagnóstico sorológico da Blastomicose Sul-Americana. Padronização da reação e comparação dos resultados com a reação de fixação de complemento. Rev. Inst. Med. trop. S. Paulo 15: 393–398.
Iwamade Mattos, M. C. F., 1979. Cell-block preparation for cytodiagnostic of pulmonary paracoccidioidomycosis. Chest 75: 212.
Jones, H. E., 1982. Ketoconazole. Arch. Dermatol. 118: 217–219.
Lacaz, C. S., 1973. Compêndio de micologia médica, 5a. ed., São Paulo, Sarvier, p. 229–271.
Londero, A. F., 1978. Epidemiologia da paracoccidioidomicose. J. Pneumol. 4: 57–59.
Negroni, R., L. J. G. Montaner, O. P. Beltran, M. A. Tuculet & D. Rey, 1979. Resultados do ketoconazole (R=41.400) en el tratamiento de la paracoccidioidomycosis. Rev. Arg. Micol. 2: 12–18.
Negroni, R., A. M. Robles, A. Arechavala, M. A. Tuculet & R. Galimberti, 1980. Ketoconazole in the treatment of paracoccidioidomycosis and histoplasmosis. Rev. Infect. Dis. 2: 643–649.
Machair, A. L., E. Gascoigne, Gascoigne, Heapj, et al., 1982. Hepatitis and ketoconazole therapy. Br. Med. J. 158: 283.
Restrepo, A., S. I. Gomes & P. M. A. Robledo, 1982. Eficácia del ketoconazole en pacientes con paracoccidioidomicosis recidivante. Rev. Inst. Med. trop. S. Paulo 24: 173–179.
Restrepo, A., M. Robledo, R. Giraldo, H. Hernandez, F. Sierra, F. Gutiérrez, F. Londoño, R. Lopez & Y. Calle, 1976. The gamut of paracoccidioidomycosis. Am. J. Med. 61: 33–42.
Siegel, S., 1975. Estatística não paramétrica. McGraw Hill do Brasil.
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Marques, S.A., Dillon, N.L., Franco, M.F. et al. Paracoccidioidomycosis: A comparative study of the evolutionary serologic, clinical and radiologic results for patients treated with ketoconazole or amphotericin B plus sulfonamides. Mycopathologia 89, 19–23 (1985). https://doi.org/10.1007/BF00437128
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DOI: https://doi.org/10.1007/BF00437128