Abstract
Just in the course of unfolding of chromosomal deoxyribonucleoproteins performed in the absence of magnesium ions all DNA-bound histones may be redistributed. This type of redistribution is completely blocked in already ‘unfolded’ DNP preparations. If the unfolding-induced histone redistribution is allowed it leads to a significant decrease of the average length of free DNA segments in the unfolded, histone F1-depleted DNP. The implications of these data on the mode of DNA packing in chromatin are discussed.
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Varshavsky, A.J., Georgiev, G.P. Redistribution of histones during unfolding of chromosomal DNA. Molecular Biology Reports 1, 143–148 (1973). https://doi.org/10.1007/BF00357154
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DOI: https://doi.org/10.1007/BF00357154