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Conformation-directed design of cyclic somatostatins containing a βVI-turn mimetic

  • Section I. Conformation and Design
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Summary

The design process and the synthetic problems for the construction of conformationally constrained cyclic somatostatins are described. Highly potent analogs containing o-aminomethylphenylacetic acid or o-aminomethylphenylalanine are obtained.

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Authors and Affiliations

  1. Organic Chemistry, Free University of Brussels, Pleinlaan 2, B-1050, Brussels, Belgium

    Dirk Tourwé

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  1. Dirk Tourwé
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Tourwé, D. Conformation-directed design of cyclic somatostatins containing a βVI-turn mimetic. Lett Pept Sci 2, 182–186 (1995). https://doi.org/10.1007/BF00119148

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  • DOI: https://doi.org/10.1007/BF00119148

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