Summary
A rational approach to the synthesis of phosphonamidate pseudopeptides is described. This strategy can be easily applied to the preparation of peptides containing phosphonic acid residues at various positions, as well as sidechain-functionalized amino acid residues. The reaction conditions are compatible with the severe lability of the P-N bond, and the absence of racemization is demonstrated by31P NMR analysis. This approach is suitable for application in solid-phase synthesis of biologically active phosphonopeptides.
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Maffre-Lafon, D., Dumy, P., Escale, R. et al. A rational approach to the synthesis of phosphonamidate peptides. Lett Pept Sci 1, 51–55 (1994). https://doi.org/10.1007/BF00132762
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DOI: https://doi.org/10.1007/BF00132762