Abstract
Ligand exchange is one of the possible synthetic routes to obtain99mTc coordination compounds. However, the success of this route depends on the availability of good precursors. The objective of this work is the preparation of the complex [99mTc(tu)6]3+ (tu = thiourea), as a potential precursor for99mTc(III) coordination compounds. The preparation was successfully performed in acidic conditions, the excess of tu serving as reducing agent. At pH values higher than 3, the compound becomes unstable and on addition of polydentate ligands new Tc(III) complexes are formed. With edta, the complex99mTc(III)-edta was obtained in high yield.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
E. Deutsch, K. Libson, S. Jurisson,Prog. Inorg. Chem., 30 (1983) 75.
T. Omori,Topics in Current Chemistry, 176 (1996) 253.
W.A. Volkert, D.E. Troutner, R.A. Holmes,Int. J. Appl. Radiat. Isot., 33 (1982) 891.
A. Fritzberg, S. Kasina, D. Eshima, D. Johnson,J. Nucl. Med., 27 (1980) 111.
R. Waloviteh, T. Hill, S. Garrity, E. Cheesman, B. Burges, D. O'Leary, A. Watson, M. Ganey, R. Morgan, S. Williams,J. Nucl. Med., 30 (1989) 1892.
S. Mastrotamatis, M. Papadopoulos, I. Pirmettis, E. Paschali, A. Varvarigou, C. Stassinopoulos, C. Raptopoulos, A. Terzis, E. Chiotellis,J. Med. Chem., 37 (1994) 3212.
M.J. Abrams, A. Davison, A. Faggiani, A.G. Jones, C.J.L. Lock,Inorg. Chem., 23 (1984) 3284.
G. Bandoli, U. Mazzi, H. Spies, R. Münze, E. Ludwig, E. Ulhemann, D. Scheller,Inorg. Chim. Acta, 132 (1987) 177.
C. Kremer, E. Kremer,J. Radioanal. Nucl. Chem., Letters, 175 (1993) 445.
M. Hashimoto, H. Wada, T. Omori, K. Yoshihara,J. Radioanal. Nucl. Chem., Letters, 153 (1991) 283.
M. Hashimoto, H. Wada, T. Omori, K. Yoshihara,Radiochim. Acta, 63 (1993) 173.
J. Gancheff, R. González, C. Kremer, E. Kremer, in: Technetium and Rhenium in Chemistry and Nuclear Medicine 4 (Ed. by M. Nicolini, G. Bandoli, U. Mazzi) SGE Editoriali, 1995.
K. Hashimoto, T. Omori,J. Radioanal. Nucl. Chem., Letters, 188 (1994) 391.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rey, A., Terán, M., Kremer, C. et al. Preparation of99mTc-thiourea complex as a precursor for Tc(III) labeled compounds. Journal of Radioanalytical and Nuclear Chemistry Letters 214, 499–508 (1996). https://doi.org/10.1007/BF02163564
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02163564