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RNAA for arsenic, cadmium, copper, and molybdenum in CNS tissues from subjects with age-related neurodegenerative diseases

  • Nuclear Analytical Methods in Biology and Medicine
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Abstract

Reactor thermal neutron irradiation of biological matrices induces high levels of intense gamma-ray or bremsstrahlung radiation from82Br,42K,24Na, and32P, that interfere with the determination of As, Cd, Cu, and Mo by INAA. Central nervous system (CNS) issue samples from subjects with Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and controls were analyzed using a simple RNAA procedure involving a rapid two-step solvent extraction procedure to determine these four elements. Significant increases (p≤0.05) in concentrations of Cd and Mo were observed for brain of AD subjects compared to controls, but significant imbalances were not observed for ALS subjects. Concentration data for these elements in selected international reference standards are also presented.

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Authors and Affiliations

  1. Department of Chemistry, Unviersity of Kentucky, 40506, Lexington, KY, USA

    L. Tandon, B. -F. Ni, X. X. Ding & W. D. Ehmann

  2. Department of Neurology, University of Kentucky, 40506, Lexington, KY, USA

    E. J. Kasarskis & W. R. Markesbery

  3. Department of Pathology, University of Kentucky, 40506, Lexington, KY, USA

    W. R. Markesbery

  4. Graduate Center for Toxicology, University of Kentucky, 40506, Lexington, KY, USA

    E. J. Kasarskis

  5. Sanders Brown Center on Aging, University of Kentucky, 40506, Lexington, KY, USA

    W. R. Markesbery

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  1. L. Tandon
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  2. B. -F. Ni
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Tandon, L., Ni, B.F., Ding, X.X. et al. RNAA for arsenic, cadmium, copper, and molybdenum in CNS tissues from subjects with age-related neurodegenerative diseases. Journal of Radioanalytical and Nuclear Chemistry, Articles 179, 331–339 (1994). https://doi.org/10.1007/BF02040168

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  • DOI: https://doi.org/10.1007/BF02040168

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