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A potential bone tumor therapeutic agent153Sm-EDTMP: Its synthesis and preliminary structure analysis

  • Radiochemical and Radioanalytical Techniques
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Abstract

Samarium-153-EDTMP (ethylene diamine tetramethylene phosphonate), for its promising biological properties, has been proved as a palliating therapeutic agent for boné cancer in human beings. In this article, we present the results on synthesis and structure analysis of Samarium-153-EDTMP. In a basic medium,153Sm-EDTMP can be readily prepared with a complexing yield not less than 98%, and it is confirmed that the ratio of the ligand to Sm is 1∶1, and the charge of153Sm-EDTMP is negative two.

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Authors and Affiliations

  1. Southwest Institute of Nuclear Physics and Chemistry, P.O. Box 515-38, 610003, Chengdu, (P. R. China)

    Sh. Zh. Luo, M. F. Pu, J. Quao, Zh. L. Liu, Ch. Y. Zhang, P. J. Zhao & Y. B. Fu

  2. Department of Nuclear Medicine, West China University of Medical Sciences, 610041, Chengdu, (P. R. China)

    H. F. Deng

Authors
  1. Sh. Zh. Luo
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  2. M. F. Pu
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  3. J. Quao
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  4. Zh. L. Liu
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  5. Ch. Y. Zhang
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  6. P. J. Zhao
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  7. Y. B. Fu
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  8. H. F. Deng
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Luo, S.Z., Pu, M.F., Quao, J. et al. A potential bone tumor therapeutic agent153Sm-EDTMP: Its synthesis and preliminary structure analysis. Journal of Radioanalytical and Nuclear Chemistry, Articles 160, 443–448 (1992). https://doi.org/10.1007/BF02037119

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  • DOI: https://doi.org/10.1007/BF02037119

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