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Synthesis of N-isopropyl-p-123I-amphetamine and biodistribution in rats

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Abstract

The described labelling and purification preparation of N-isopropyl-p-131I-amphetamine /131I-IMP/ represents a fast and efficient method to obtain a compound that fulfils all criteria of purity for its in-vivo application. After isotope exchange and quality control131I-IMP could be obtained with radiochemical yields in the range between 68% and 78% with a radiochemical purity of 98–99%. As demonstrated in animal experiments the cerebral affinity of IMP offers a possibility for the diagnosis of brain diseases in clinical studies when the product is labelled with123I.

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References

  1. H.S. Winchell, R.M. Baldwin, T.H. Lin,J. Nucl. Med., 21 /1980/ 940.

    PubMed  Google Scholar 

  2. T. Sargent, U. Braun, G. Braun,J. Nucl. Med., 19 /1978/ 72.

    Google Scholar 

  3. H. S. Winchell, W.D. Horst, L. Braun, W.H. Oldendorf, R. Hattner, H. Parker,J. Nucl. Med., 21 /1980/ 947.

    PubMed  Google Scholar 

  4. M.B. Cohen, L.S. Graham, L.S. Yamada,Appl. Radiation Isotopes, 17 /1986/ 749.

    Google Scholar 

  5. B.L. Holman, T.C. Hill, R.G. Lee, R.E. Zimmerman, S.C. Moore, H.D. Royal. Brain Imaging with Radiolabelled Amines, in: Nuclear Medicine Annual /Eds by L.M. Freeman, H.S. Weissman/, Raven Press, New York, 1983, p. 131.

    Google Scholar 

  6. E.J. Knust, H.-J. Machulla, R.M. Baldwin, T. Chen, L.E. Feinendegen,Nuklearmedizin, 23 /1984/ 31.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Instituto de Pesquisas Energéticas e Nucleares, /IPEN/, CNEN/SP, São Paulo, Brazil

    M. Figols, R. da S. V. Gonçalves, E. Muramoto, S. Sato, M. T. Colturato & C. P. Gonçalves

  2. Dirección General de Energia Nuclear, Guatemala

    D. Y. Freire Martinez

  3. Radiologisches Zentrum, Universitätsklinikum, D-4300, Essen, FRG

    J. Knust

Authors
  1. M. Figols
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  2. R. da S. V. Gonçalves
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  3. E. Muramoto
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  4. S. Sato
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  5. D. Y. Freire Martinez
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  6. M. T. Colturato
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  7. C. P. Gonçalves
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  8. J. Knust
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Figols, M., Gonçalves, R.d.S.V., Muramoto, E. et al. Synthesis of N-isopropyl-p-123I-amphetamine and biodistribution in rats. Journal of Radioanalytical and Nuclear Chemistry Letters 136, 331–339 (1989). https://doi.org/10.1007/BF02164725

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  • DOI: https://doi.org/10.1007/BF02164725

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