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Spatial differences in patterns of modification: selection on hairy in Drosophila melanogaster wings

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Abstract

Artificial selection was carried out for over 45 generations to enhance and suppress expression of the mutation hairy on the Drosophila melanogaster wing. Whole chromosome mapping of X‐linked and autosomal modifiers of sense organ number displayed regional differences in magnitude and direction of their effects. Regional specificity of modifier effects was also seen in some interchromosomal interactions. Scanning electron microscopy allowed precise measurement of sense organ size and position along the L3 longitudinal wing vein. Sense organ size varied in a predictable fashion along the proximal–distal axis, and the dorsal pattern differed from the ventral pattern. The high and low selection lines differed most in the proximal portion of the L3 vein. Extra sense organs in the High line were often associated with vein fragments at locations predicted from ancestral vein patterns. Thus, regional specificity of polygenic or quantitative trait locus modifier effects was identified in several different parts of the wing.

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References

  • Blair, S.S., A. Giangrande, J.B. Skeath & J. Palka, 1992. The development of normal and ectopic sensilla in the wings of hairy and Hairy wing mutants of Drosophila. Mech. Dev. 38: 3–16.

    Article  PubMed  CAS  Google Scholar 

  • Botas, J., J. Moscoso del Prado & A. García-Bellido, 1982. Genedose titration analysis in the search of trans-regulatory genes in Drosophila. EMBO J. 1 (3): 307–310.

    PubMed  CAS  Google Scholar 

  • Campos-Ortega, J.A. & Y.N. Jan, 1991. Genetic and molecular bases of neurogenesis in Drosophila melanogaster. Annu. Rev. Neurosci. 14: 399–420.

    Article  PubMed  CAS  Google Scholar 

  • Dambly-Chaudière, C. & M. Vervoort, 1998. The bHLH genes in neural development. Int. J. Dev. Biol. 42: 269–273.

    PubMed  Google Scholar 

  • García-Bellido, A., 1977. Inductive mechanisms in the process of wing vein formation in Drosophila. Wilhelm Roux's Archives 182: 93–106.

    Article  Google Scholar 

  • Ghysen, A. & C. Dambly-Chaudière, 1988. From DNA to form: the achaete-scute complex. Genes Dev. 2: 495–501.

    PubMed  CAS  Google Scholar 

  • Ghysen, A., C. Dambly-Chaudière, L.Y. Jan & Y.N. Jan, 1993. Cell interactions and gene interactions in peripheral neurogenesis. Genes Dev. 7: 723–733.

    PubMed  CAS  Google Scholar 

  • Hassan, B. & H. Vaessin, 1996. Regulatory interactions during early neurogenesis in Drosophila. Dev. Genetics 18: 18–27.

    Article  CAS  Google Scholar 

  • Held, L.I., Jr., 1991. Bristle patterning in Drosophila. BioEssays 13(12): 633–640.

    Article  PubMed  Google Scholar 

  • Ingham, P.W., S.M. Pinchin, K.R. Howard & D. Ish-Horowicz, 1985. Genetic analysis of the hairy locus in Drosophila melanogaster. Genetics 111: 463–486.

    Google Scholar 

  • Jan, Y.N. & L.Y. Jan, 1993. The peripheral nervous system, pp. 1207–1240 in The Development of Drosophila melanogaster, edited by M. Bate & A. Martinez Arias. Cold Spring Harbor Laboratory Press.

  • Jiménez, F. & J. Modolell, 1993. Neural fate specification in Drosophila. Current Opinion in Gene. Dev. 3: 626–632.

    Article  Google Scholar 

  • Lindsley, D.L. & G.G. Zimm, 1992. The Genome of Drosophila melanogaster. New York: Academic Press, Inc.

    Google Scholar 

  • Lynch, M. & B. Walsh, 1998. Genetics and Analysis of Quantitative Traits. Sinauer Associates, Inc., Sunderland, MA.

    Google Scholar 

  • Mather, K., 1943. Polygenic inheritance and natural selection. Biol. Rev. 18: 32–64.

    Google Scholar 

  • Moscoso del Prado, J. & A. Garcia-Bellido, 1984. Genetic regulation of the achaete-scute complex in Drosophila melanogaster. Roux's Arch. Dev. Biol. 193: 242–245.

    Article  Google Scholar 

  • Oshako, S., J. Hyer, G. Panganiban, I. Oliver & M. Caudy, 1994. Hairy function as a DNA-binding helix-loop-helix repressor of Drosophila sense organ formation. Genes Dev. 8: 2743–2755.

    Google Scholar 

  • Rushlow, C.A., A. Hogan, S.M. Pinchin, K.M., Howe, M. Lardelli & D. Ish-Horowicz, 1989. The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc. The EMBO J. 8(10): 3095–3103.

    CAS  Google Scholar 

  • Schnee, F.B. & J.N. Thompson, Jr., 1984. Conditional polygenic effects in the sternopleural bristle system of Drosophila melanogaster. Genetics 60: 71–76.

    Google Scholar 

  • Sturtevant, A.H., 1970. Studies on the bristle pattern of Drosophila. Dev. Biol. 21: 48–61.

    Article  PubMed  CAS  Google Scholar 

  • Thoday, J.M. & J.N. Thompson, Jr., 1976. The number of segregating genes implied by continuous variation. Genetica 46: 335–344.

    Article  Google Scholar 

  • Thompson, J.N., Jr., 1974. Studies on the nature and function of polygenic loci in Drosophila. II. The subthreshold wing vein pattern revealed in selection experiments. Heredity 33: 389–401.

    PubMed  Google Scholar 

  • Thompson, J.N., Jr., 1975a. Quantitative variation and gene number. Nature 258: 665–668.

    Article  PubMed  Google Scholar 

  • Thompson, J.N., Jr., 1975b. Studies on the nature and function of polygenic loci in Drosophila. III. veinlet modifiers having region-specific effects upon the vein pattern. Genetics 81: 387–402.

    Google Scholar 

  • Thompson, J.N., Jr., 1977. Analysis of gene number and polygenic systems. Stadler Symp. 9: 63–82.

    Google Scholar 

  • Thompson, J.N., Jr. & A.D. Preston, 1992. The Drosophila segmentation gene hairy responds to a late postembryonic gradient in the wing. Dros. Inf. Serv. 71: 247–249.

    Google Scholar 

  • Thompson, J.N., Jr. & R.C. Woodruff, 1982. Polygenic analysis of pattern formation: Interdependence among veins in the same compartment of the Drosophila wing. Genetica 60: 71–76.

    Article  Google Scholar 

  • Thompson, J.N., Jr., J.J. Hellack & J.S. Kennedy, 1982. Polygenic analysis of pattern formation in Drosophila: Specification of companiform sensilla positions on the wing. Dev. Genetics 3: 115–128.

    Article  Google Scholar 

  • Vaessin, H., M. Caudy, E. Bier, L.Y. Jan & Y.N. Jan, 1990. Role of helix-loop-helix proteins in Drosophila neurogenesis. Cold Spring Harbor Symposium on Quantitative Biology, 55: 239–245.

    CAS  Google Scholar 

  • Van Doren, M., A.M. Bailey, J. Esnayra, K. Ede & J.W. Posakony, 1994. Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete. Genes Dev. 8: 2729–2742.

    PubMed  CAS  Google Scholar 

  • Weber, K., R. Eisman, L. Morey, A. Patty, J. Sparks, M. Tausek & Z.B. Zeng, 1999. An analysis of polygenes affecting wing shape on chromosome 3 in Drosophila melanogaster. Genetics 153: 773–786.

    PubMed  CAS  Google Scholar 

  • Zimmerman, E., A. Palsson & G. Gibson, 2000. Quantitative trait loci affecting components of wing shape in Drosophila melanogaster. Genetics 155: 671–683.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Zoology, University of Oklahoma, Norman, OK, 73019, USA

    Russell B. Fletcher & James N. Thompson Jr.

  2. Department of Molecular and Cell Biology, University of California, Berkeley, CA

    Russell B. Fletcher

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  1. Russell B. Fletcher
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  2. James N. Thompson Jr.
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Fletcher, R.B., Thompson, J.N. Spatial differences in patterns of modification: selection on hairy in Drosophila melanogaster wings. Genetica 109, 169–181 (2000). https://doi.org/10.1023/A:1017531404454

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