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Immunohistochemical distribution of MAM-3 and MAM-6 antigens in developing salivary glands of the human fetus

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Summary

The immunohistochemical expression of MAM-3 and MAM-6 antigens was studied in developing human fetal salivary gland removed at autopsy of 22 normal fetuses of varying maturity (10–40 weeks of gestation). The onset of functional maturation in the fetal gland was seen at 21 weeks of gestational maturity. The acini and ducts then underwent distinct alterations in antigen expression with growth and maturation until the late developmental stage (33–40 weeks of gestation) when they resemble the adult salivary gland. The role of maturing duct cells in histogenesis of salivary gland tumours is discussed.

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References

  • Gusterson, B. A., Lucas, R. B. &Ormerod, M. G. (1982) Distribution of epithelial membrane antigen in benign and malignant lesion of the salivary glands.Virchows Arch. (Pathol. Anat.) 397, 227–33.

    Google Scholar 

  • Hilkens, J., Buijs, F., Hilliers, J., Hageman, Ph.,Calafat, J., Sonnenberg, A. &Van Der Valk, M. (1984) Monoclonal antibodies against human fat globule membrane detecting differentiation antigens of the mammary gland and its tumors.Int. J. Cancer 34, 197–206.

    Google Scholar 

  • Hilkens, J., Hilgers, J., Buijs, F., Hageman, Ph.,Schol, D., Van Doornewaard G. &Van Der Tweel, J. (1984b) Monoclonal antibodies against human milk fat globule membranes useful in carcinoma reaction. InProtides of the Biological Fluids, Vol. 31 (edited byPeekers, H.) pp. 728–35. Oxford/New York: Pergamon Press.

    Google Scholar 

  • Hilkens, J. (1988) Biochemistry and function of mucins in malignant disease.Cancer Res. 11–12, 25–54.

    Google Scholar 

  • Hilkens, J., Buijs, F., Ligtenberg, M. (1989) Complexity of MAM-3, an epithelial sialomucin associated with carcinomas.Cancer Res. 49, 786–93.

    Google Scholar 

  • Lee, S. K., Lim, C. Y., Chi, J. G., Yamada, K., Hashimura, H., Kunikata, M. &Mori, M. (1990) Prenatal development of human major salivary glands and immunohistochemical detection of keratins using monoclonal antibodies.Acta Histochem. 89, 213–35.

    Google Scholar 

  • Noda, Y., Horike, H., Watanabe, Y., Mori, M. &Tsujimura, T. (1987) Immunohistochemical identification of epithelial membrane antigen in sweat gland tumours by the use of a monoclonal antibody.Path. Res. Pract. 182, 797–807.

    Google Scholar 

  • Pinkus, G. S. &Kurtin, P. J. (1985) Epithelial membrane antigen—a diagnostic discriminant in surgical pathology. Immunohistochemical profile in epithelial, mesenchymal and hematopoietic neoplasms using paraffin sections and monoclonal antibodies.Hum. Pathol. 16, 929–40.

    Google Scholar 

  • Tatemoto, Y., Kumasa, S., Watanabe, Y. &Mori, M. (1987a) Immunohistochemical expression of monoclonal antibody against epithelial membrane antigen in salivary gland tumors.Acta Histochem. Cytochem. 20, 113–24.

    Google Scholar 

  • Tatemoto, Y., Kumasa, S., Watanabe, Y. &Mori, M. (1987b) Epithelial membrane antigen as a marker of human salivary gland acinar and ductal cell function.Acta Histochem. 82, 219–26.

    Google Scholar 

  • Tsubura, A., Morii, S., Hilkens, J. &Hilgers, J. (1985) Expression of MAM-3 and MAM-6 antigens on endometrial and endocervical carcinomas.Virchows Arch. (Pathol. Anat.)407, 59–67.

    Google Scholar 

  • Tsubura, A., Morii, S., Ueda, S., Sasaki, M., Zotter, St.,Watzig, V., Mooi, W., Hageman, Ph.C., Hilkins, J., Van Der Tweel, J., Meijer, C. &Hilgers, J. (1987) Immunohistochemical demonstration of MAM-3 and MAM-6 antigens in normal human skin appendages and their tumors.Arch. Dermatol. Res. 279, 550–7.

    Google Scholar 

  • Yamada, K., Tanaka, T., Mori, M., Tsubura, A., Morii, S., Tsubone, M., Ando, C. &Hilgers, J. (1989) Immunohistochemical expression of MAM-3 and MAM-6 antigens in salivary gland tumors.Virchows Arch. (Pathol. Anat.) 415, 523–32.

    Google Scholar 

  • Zotter, S., Lossnitzer, A., Kunze, K. S., Muller, M., Hilkens, J., Hilgers, J. &Hageman, P. (1985) Epithelial markers for paraffin-embedded human tissues. Immunohistochemistry with monoclonal antibodies against milk fat globule antigens.Virchows Arch. (Pathol. Anat.) 406, 237–51.

    Google Scholar 

  • Zotter, S., Hageman, P. C., Lossnitzer, A., Mooi, W. J. &Hilgers, J. (1988a) Tissue and tumor distribution of human polymorphic epithelial mucin.Cancer Res. 11–12, 55–101.

    Google Scholar 

  • Zotter, St.,Hageman, Ph.C., Lossnitzer, A., Van Den Tweel, J. Hilkens, J., Mooi, W. J. &Hilgers, J. (1988b) Monoclonal antibodies to epithelial sialomucins recognize epitopes at different cellular sites in adenolymphomas of the parotid gland.Int. J. Cancer. Supp. 3, 38–44.

    Google Scholar 

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Authors and Affiliations

  1. Department of Oral Pathology, College of Dentistry, Seoul National University, Seoul, Korea

    S. K. Lee & C. Y. Lim

  2. Department of Pathology, College of Medicine, Seoul National University, Seoul, Korea

    J. G. Chi

  3. Department of Oral and Maxillofacial Surgery, Asahi University, School of Dentistry, Gifu, Japan

    K. Yamada & M. Mori

  4. Department of Pathology, Kansai Medical University, Moriguchi, Osaka, Japan

    A. Tsubura & S. Morii

  5. Department of Obstetrics and Gynecology, Academical Hospital Free University, Amsterdam, The Netherlands

    J. Hilgers

  6. Department of Pathology, Sri Ramachandra Medical College, Tamarai, Madras, India

    M. Govindarajan

Authors
  1. S. K. Lee
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  2. C. Y. Lim
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  3. J. G. Chi
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  4. K. Yamada
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  5. M. Mori
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  6. A. Tsubura
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  7. S. Morii
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  8. J. Hilgers
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  9. M. Govindarajan
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Lee, S.K., Lim, C.Y., Chi, J.G. et al. Immunohistochemical distribution of MAM-3 and MAM-6 antigens in developing salivary glands of the human fetus. Histochem J 23, 355–360 (1991). https://doi.org/10.1007/BF01042180

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  • DOI: https://doi.org/10.1007/BF01042180

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