Synopsis
The cholinergic and adrenergic innervation of human minor sublingual buccal and labial salivary glands has been studied with histochemical techniques for localizing acetylcholinesterase and catecholamines. A rich cholinergic innervation was observed around the acini, blood vessels and some ducts of the three glands.
The adrenrgic innervation, however, was virtually absent from the parenchyma although present around the blood vessels, in marked contrast to the dense parenchymal adrenergic innervation observed in the human parotid and submandibular glands. These results suggest that the autonomic nervous mechanism which regulates salivary secretion is more elaborate in the major than in the minor salivary glands.
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References
Alm, P., Bloom, G. D. &Carlsöö, B. (1973). Adrenergic and cholinergic nerves of bovine, guinea pig and hamster salivary glands. A light and electron microscopic study.Z. Zellforsch. 138, 407–20.
Emmelin, N., (1967a). Nervous control of salivary glands. In:Handbook of Physiology, Section 6, Vol. II. pp. 595–632. Washington: American Physiological Society.
Emmerlin, N. (1967b) Secretion from denervated salivary glands. In:Secretory Mechanisms of Salivary Glands. (eds. L. H. Schneyer and C. A. Schneyer), pp. 127–41. New York: Academic Press.
Eränkö, O. (1967). Histochemistry of nervous tissues: catecholamines and cholinesterases.Ann. Rev. Pharmac. 7, 203–22.
Eränkö, O. &Eränkö, L. (1971). Loss of histochemically demonstrable catecholamines and acetylcholinesterase from sympathetic nerve fibres of the pineal body of the rat after chemical sympathectomy with 6-hydroxydopamine.Histochem. J. 3, 357–63.
Freitag, P. &Engel, M. B. (1970). Autonomic innervation in rabbit salivary glands.Anat. Rec. 167, 87–105.
Fujiwara, M., Tanaka, C., Hattori, K. &Honjo, T. (1966a). Uptake of noradrenaline by the adrenergic fibres of the submaxillary and sublingual glands of the rat.Biochem. Pharmac. 15, 2113–7.
Fujiwara, M., Tanaka, C., Hirosaka, H., &Okegawa, T. (1966b). Cytological localization of noradrenaline, monoamine-oxidase and acetylcholinesterase in salivary glands of dog.J. Histochem. Cytochem. 14, 483–90.
Garrett, J. R. (1972). Neuro-effector sites in salivary glands. In:Oral Physiology (eds. N. Emmelin and Y. Zotterman), pp. 83–97. Oxford: Pergamon Press.
Garrett, J. R. (1974). Innervation of salivary glands. Morphological considerations. In:Secretory Mechanisms of Exocrine Glands (eds. N. A. Thorn and O. H. Petersen), pp. 17–28. New York: Academic Press.
Hamberger, B., Norberg, K. A. &Olson, L. (1967). Extraneuronal binding of catecholamines and 3,4-dihydroxyphenylalanine (DOPA) in salivary glands.Acta physiol. scand. 69, 1–12.
Harrison, J. D., Sowray, J. H. &Smith, N. J. D. (1976). Recurrent ranula. A case report.Br. dent. J. 140, 180–2.
Karnovsky, J. &Roots, T. (1964). A ‘direct coloring’ thiocholine method for cholinesterase.J. Histochem. Cytochem. 12, 219–21.
Norberg, K. A. &Olson, L. (1965). Adrenergic innervation of the salivary glands in the rat.Z. Zellforsch. 68, 183–9.
Olson, L. (1967). Outgrowth of sympathetic adrenergic neurons in mice treated with a nerve growth factor (NGF).Z. Zellforsch. 81, 155–73.
Read, J. B. &Burnstock, G. (1969). A method for the localization of adrenergic nerves during early development.Histochemie 20, 197–200.
Rossoni, R. B., Machado, A. B. M. &Machado, C. R. S. (1973). Autonomic innervation of the salivary glands in the marmoset (Callithrix penicillata jordani) with some gross anatomical and histological observations.Archs oral Biol. 18, 879–88.
Sachs, C. (1970). Noradrenaline uptake mechanisms in the mouse atrium. A biochemical and histochemical study.Acta physiol. scand. Suppl.341.
Tandler, B. &Ross, L. L. (1969). Observations of nerve terminals in human labial salivary glands.J. Cell Biol. 42, 339–43.
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Rossoni, R.B., Machado, A.B. & Machado, C.R.S. A histochemical study of catecholamines and cholinesterases in the autonomic nerves of the human minor salivary glands. Histochem J 11, 661–668 (1979). https://doi.org/10.1007/BF01004730
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DOI: https://doi.org/10.1007/BF01004730