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Synthesis of phosphinic and phosphoric analogs of aspartic acid

  • Organic Chemistry
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Russian Chemical Bulletin Aims and scope

Abstract

Approaches to the synthesis of 1-amino- and 2-amino-2-carboxyethylphosphinic and-phosphoric acids have been studied. A convenient method for the preparation of phosphinic acids is the reactions of ethyl diethoxymethylphosphonite with ethyl acetamidomethylenemalonate and ethyl 2-acetamidoacrylate.

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References

  1. J. S. Kittredge and R. R. Hughes,Biochemistry, 1964,3, 991.

    Google Scholar 

  2. P. Kafarski, B. Lejczak, P. Mastaters, D. Dus, and C. Radzikowski,J. Med. Chem., 1985,28, 1558.

    PubMed  Google Scholar 

  3. E. N. Khurs, T. I. Osipova, and R. M. Khomutov,Bioorg. Aim., 1989,15, 554 [Russ. J. Bioorgan. Chem., 1989,15 (Engl. Transi.)].

    Google Scholar 

  4. E. K. Baylis, C. D. Campbell, and J. G. Dingwall,J. Chem. Soc. Perkin Trans. 1, 1984, 2845.

  5. D. Grobenly,Synthesis, 1987, 942.

  6. X.-Y. Jiao, C. Verbruggen, M. Borloo, W. Bollaert, A. De Groot, R. Dommisse, and A. Haemers,Synthesis, 1994, 23.

  7. L. Maier and P. J. Diel,Phosphorus, Sulfur and Silicon, 1991,57, 57.

    Google Scholar 

  8. R. M. Khomutov and T. I. Osipova,Izv. Akad. Nauk SSSR, Ser. Khim., 1978, 1951 [Bull. Acad. Sci. USSR, Div. Chem. Sci., 1978,27, 1722 (Engl. Transi.)].

  9. P. P. McCleery and B. Tuck,J. Chem. Soc., Perkin Trans. I, 1989, 1319.

  10. J. G. Dingwall, J. Ehrenfreund, and R. G. Hall,Tetrahedron, 1989,45, 3787.

    Google Scholar 

  11. M. J. Gallagher and H. Honegger,Aust. J. Chem., 1980,33, 287.

    Google Scholar 

  12. M. Soroka and P. Mastalerz,Rocz. Chem., 1976,50, 661.

    Google Scholar 

  13. H. Pechmann,Ann., 1891,264, 261.

    Google Scholar 

  14. R. M. Khomutov, T. 1. Osipova, and Yu. N. Zhukov,Izv. Akad. Nauk SSSR, Ser. Khim., 1978, 1391 [Bull Acad. Sci. USSR, Div. Chem. Sci., 1978,27, 1210 (Engl. Transl.)].

    Google Scholar 

  15. H. Hellman, K. Teichmann, and F. Lingeus,Chem. Ber., 1958,91, 2427.

    Google Scholar 

  16. M. E. Chambers and A. F. Isbell,J. Org. Chem., 1964,29, 832.

    Google Scholar 

  17. J. P. Berrg, A. F. Isbell, and G. E. Hunt,J. Org. Chem., 1972,37, 4396.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. A. N. Bakh Institute of Biochemistry, Russian Academy of Sciences, 33 Leninsky prosp., 117071, Moscow, Russian Federation

    A. R. Khomutov

  2. V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 ul. Vavilova, 117984, Moscow, Russian Federation

    T. I. Oslpova, E. N. Khurs, K. V. Alferov & R. M. Khomutov

Authors
  1. A. R. Khomutov
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  2. T. I. Oslpova
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  3. E. N. Khurs
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  4. K. V. Alferov
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  5. R. M. Khomutov
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Additional information

Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 2066–2069, August, 1996.

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Khomutov, A.R., Oslpova, T.I., Khurs, E.N. et al. Synthesis of phosphinic and phosphoric analogs of aspartic acid. Russ Chem Bull 45, 1961–1964 (1996). https://doi.org/10.1007/BF01457787

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  • DOI: https://doi.org/10.1007/BF01457787

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