Abstract
Cement samples made of β-tricalcium phoshate (β-TCP), phosphoric acid (PA) and water mixtures were incubated in several aqueous solutions to determine their stability over time. The effects of the cement composition and the incubating temperature were investigated in more detail. The cement samples contained mostly dicalcium phosphate dihydrate (DCPD) and remnants of β-TCP crystals. Depending on the initial cement composition, a certain amount of dicalcium phosphate (DCP) crystals were formed. The larger the initial PA concentration, the larger the DCP amount. After setting, the cement composition was stable for at least 16 days up to 60 °C. Above that temperature, the DCPD crystals decomposed into DCP crystals. The latter reaction provoked a decrease of the pH of the incubation solution, phenomenon expected for a cement sample containing an excess of PA. As the cement samples contained an excess of β-TCP, it was postulated that β-TCP crystals became so covered by DCP or DCPD crystals during setting that the setting reaction was stopped prematurely. The latter phenomenon gave a good explanation for the low pH values measured in the incubation solutions. ©©2000 Kluwer Academic Publishers
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J. LEMAÎTRE, A. A. MIRTCHI and A. MORTIER, Silicates Industriels 9-10 (1987) 141.
A. A. MIRTCHI, J. LEMAÎTRE and N. TERAO, Biomaterials 10 (1989) 475.
E. MUNTING, A. A. MIRTCHI and J. LEMAÎTRE, J. Mater. Sci. Mater. Med. 4 (1993) 337.
K. OHURA, M. BOHNER, P. HARDOUIN, J. LEMAÎTRE, G. PASQUIER and B. FLAUTRE, J. Biomed. Mater. Res. 30 (1996) 193.
R. C. WEAST, M. J. ASTLE and W. H. BEYER, “67th CRC Handbook of Chemistry and Physics”, (Eds) (CRC Press, Boca Raton, FL, 1986) p. B-81.
M. BOHNER, PhD thesis No. 1171, Swiss Federal Institute of Technology (EPFL), Lausanne (1993).
J. M. LAUSIER, C.-W. CHIANG, H. A. ZOMPA and C. T. RHODES, J. Pharm. Sci. 66 (1977) 1636.
H. BASSETT, Chem. Soc. J. 601 (1958) 2949.
B. KOSAR-GRASIC, B. PURGARIC and H. FÑRED I-MILHOFER, J. Inorg. Nucl. Chem. 40 (1978) 1877.
R. I. MARTIN and P. W. BROWN, J. Amer. Ceram. Soc. 80 (1997) 1263.
M. BOHNER, P. VAN LANDUYT, H. P. MERKLE and J. LEMAÎTRE, J. Mater. Sci. Mater. Med. 8 (1997) 675.
M. BOHNER, J. LEMAÎTRE and T. A. RING, in “Proceedings of the Third Euro-Ceramics Conference”, Madrid, September 1993, edited by P. Durán and J. F. Fernaández (Faenza Editrice Iberica, Agenda del Rey, Spain, 1993) p. 95.
W. E. BROWN, in 'Environmental Phosphorus Handbook'', edited by E. J. Griffin, A. Beeton, J. M. Spencer and D. T. Mitchell (Wiley, New York, 1973) p. 203-38.
T. M. GREGORY, E. C. MORENO and W. E. BROWN, J. Res. Nat. Bur. Stand. 74A (1970) 461.
H. MCDOWELL, W. E. BROWN and J. R. SUTTER, Inorg. Chem. 10 (1971) 1638.
M. FRÊCHE and J. C. HEUGHEBAERT, J. Crystal Growth 94 (1989) 947.
M. T. FULMER and P. W. BROWN, J. Mater. Res. 8 (1993) 1687.
M. BOHNER, J. LEMAÎTRE, P. VAN LANDUYT, P.-Y. ZAMBELLI, H. P. MERKLE and B. GANDER, J. Pharm. Sci. 86 (1997) 565.
M. BOHNER, J. LEMAÎTRE and T. A. RING, J. Amer. Ceram. Soc. 79 (1996) 1427.
T. M. GREGORY, E. C. MORENO, J. M. PATEL and W. E. BROWN, J. Res. Nat. Bur. Stand. 78A (1974) 667.
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Bohner, M., Merkle, H.P. & Lemai^tre, J. In vitro aging of a calcium phosphate cement. Journal of Materials Science: Materials in Medicine 11, 155–162 (2000). https://doi.org/10.1023/A:1008927624493
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DOI: https://doi.org/10.1023/A:1008927624493