Abstract
We have demonstrated the presence of estrogen receptor mRNA and the mature protein in the cytoplasm and nucleus, respectively, of a 9,10-dimethyl-1,2-benzathracene-induced submandibular gland tumor in female rats. We have previously shown that progesterone receptors are also present in human salivary gland tumors. These results suggest that endocrine therapy may be effective in treatment of submandibular gland tumors.
Similar content being viewed by others
References
King, W. J., and Greene, G. L., Nature307 (1984) 745.
Liposits, Z., Kallo, I., Coen, C. W., Paull, W. K., and Flerko, B., Histochemistry93 (1990) 233.
McClellan, M. C., West, N. B., Tacha, D. E., Greene, G. L., and Brenner, R. M., Endocrinology114 (1984) 2002.
Okulicz, W. C., Padykula, H. A., Kaiserman-Abramof, I. R., and Longcope, C., J. Cell Biol.105 (1987) 9A.
Okulicz, W. C., Savasta, A. M., Hoberg, L. M., and Longcope, C., Endocrinology125 (1989) 930.
Horwitz, K. B., McGuire, W. L., Pearson, O. H., and Segaloff, A., Science189 (1975) 726.
Paridaens, R., Sylvester, R. J., Ferrazzi, E., Legros, N., Leclercq, G., and Heuson, J. C., Cancer46 (1980) 2889.
Ozono, S., Onozuka, M., Sato, K., and Ito, Y., Cell Struct. Func.16 (1991) 511.
Ozono, S., Onozuka, M., Sato, K., and Ito, Y., Cell Struct. Func.17 (1992) 169.
Koike, S., Sakai, M., and Muramatsu, M., Nucleic Acids Res.15 (1987) 2499.
Lauber, A. H., Mobbs, C. V., Muramatsu, M., and Pfaff, D. W., Endocrinology129 (1990) 3180.
Bakker, G. H., Setyono-Han, H., Portengen, S. H., Jong, F. H. D., Foekens, J. A., and Klijin, J. G. M., Endocrinology125 (1989) 1593.
McGuire, W. L., Carbone, P. P., Sears, M. L., and Escher, G. C., Estrogen Receptors in Human Breast Cancer: An Overview, p. 7. Eds W. L. McGuire, P. P. Carbone and E. P. Voumer. Raven Press, New York 1975.
Shyamala, G., and Ferenczy, A., Endocrinology115 (1984) 1078.
Stumpf, W. E., and Sar, M., Autoradiographic Localization of Estrogen, Androgen, Progestin, and Glucocorticosteroid in ‘Target Tissues’ and ‘Non-target Tissues’, p. 41. Ed. J. R. Pasqualini. Marcel Dekker, New York 1976.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ozono, S., Sato, K., Ito, Y. et al. Immunohistochemical evidence that tumors elicit the synthesis of estrogen receptors in the submandibular gland of female rats. Experientia 51, 220–222 (1995). https://doi.org/10.1007/BF01931100
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01931100