Abstract
In mammary explants of lactating mice, changes in the intensity of chemiluminescence (CL) were observed after the addition to the incubation medium of hormones and mediators that are involved in the regulation of secretion: oxytocin, acetylcholine, epinephrine and norepinephrine. A 15-min period of treatment with oxytocin, epinephrine or norepinephrine changed the level of thiobarbituric acid-reactive substances (TBARS). Two mammary explants, one of which was treated with oxytocin, acetylcholine, epinephrine or norepinephrine, were found to interact even when separated by a quartz glass wall. Analysis of the level of TBARS formation in these two explants showed that the observed interactions might be connected with light emission resulting from lipid peroxidation (LP) processes. The possible role of LP and low-level CL in the regulation of mammary gland secretion is discussed.
Similar content being viewed by others
Literature
Antonov, V. F., Lipids and ion permeability of membranes. Nauka, Moscow 1982 (in Russian).
Burlakova, Y. B., Arkhipova, G. V., Goloschapov, A. N., Molochkina, Y. M., and Khokhlov, A. P., in: Bioantioxidants in the Metabolism Control in Norm and Pathology, p. 74. Ed. A. Zhuravljov. Nauka, Moscow 1982 (in Russian).
Kappus, H., in: Oxidative Stress, p. 273. Ed. H. Sies. Academic Press, London 1985.
Ohyashiki, T., Sakata, N., Kamata, K., and Matsui, K., Biochim. biophys. Acta1067 (1991) 159.
Gast, K., Zirwer, D., Ladhoff, A.-M., Schreiber, J., Koelsch, R., Kretschmer, K., and Lasch, J., Biochim. biophys. Acta686 (1982) 99.
Lands, W. E. M., Kulmacz, R. J., and Marshall, P. J., in: Free Radicals in Biology, vol. 6, p. 39. Ed. W. A. Pryor. Academic Press, New York 1984.
Needleman, P., Turk, J., Jakschi, K. B. A., Morrison, A. R., and Lefkowith, J. B., A. Rev. Biochem.55 (1986) 69.
Zhuravljov, A. I., in: Biochemiluminescence, p. 3. Ed. A. Zhuravljov. Nauka, Moscow 1983 (in Russian).
Cadenas, B., Boveris, A., and Chance, B., in: Free Radicals in Biology, vol. 6, p. 211. Ed. W. A. Pryor. Academic Press, New York 1984.
Murphy, M. E., and Sies, H., in: Methods in Enzymology, Vol. 186, p. 595. Eds L. Packer and A. N. Glazer. Academic Press, San Diego 1990.
Gurvitsch, A. G., Das Problem der Zellteilung physiologisch betrachtet. J. Springer, Berlin 1926.
Hollaender, A., and Claus, W. D., Bull. natl Res. Coun. (Washington)100 (1937) 9.
Kaznacheev, V. P., and Mikhailova, L. P., Ultraweak photoemission in cell interactions. Nauka, Novosibirsk 1981 (in Russian).
Goorvitch, A. A., Stefanov, S. B., and Lazurkina, N. N., Usp. Sovrem. Biol.99 (1985) 242.
Colli, L., and Facchini, V., Nuovo cim.12 (1954) 150.
Tarusov, B. N., Polyvoda, A. I., and Zhuravljov, A. I., RadiobiologiaI (1961) 150.
Vladimirov, Y. A., Litvin, F. F., and Tan-Man-Tzi, Biofizika7 (1962) 675.
Quickenden, T. I., and Que Hec, S. S., Photochem. Photobiol.23 (1976) 201.
Grachev, I. I., Popov, S. M., and Slepenkov, S. V., Vest. leningr. gos. univ.I (1978) 76.
Popov, S. M., Cellular mechanisms of the secretory process regulation in the mammary gland. Leningrad University Press, Leningrad 1989 (in Russian).
Grachev, I. I., Popov, S. M., and Skopitchev, V. G., Cytophysiology of milk secretion. Nauka, Liningrad 1976 (in Russian).
Lowry, O. H., Rosenbrough, H., Farr, A., and Randell, B., J. biol. Chem.193 (1951) 265.
Karnaukh, I. I., Uryson, B. V., in: Biochemiluminescence, p. 118. Ed. A. I. Zhuravljov. Nauka, Moscow 1983 (in Russian).
Lankin, V. Z., Gurevitch, S. M., Burlakova, Y. B., in: Bioantioxidants, p. 73. Ed. I. I. Ivanov. Nauka, Moscow 1975 (in Russian).
Slater, T. F., in: Methods in Enzymology, vol. 105, p. 283. Ed. L. Packer. Academic Press, Orlando 1984.
Bird, R. P., in: Methods in Enzymology, vol. 105, p. 299. Ed. L. Packer. Academic Press, Orlando 1984.
Halliwell, B., and Gutteridge, J. M. C., in: Methods in Enzymology, vol. 186, p. 1. Eds. L. Packer and A. N. Glazer. Academic Press, San Diego 1990.
Mostovnikov, V. A., and Khokhlov, I. V., Interaction of human cells via waves of optical range, Preprint N 128 Institute of Physics, Byelo-Russia Academy of Science, Minsk 1977 (in Russian).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Galantsev, V.P., Kovalenko, S.G., Moltchanov, A.A. et al. Lipid peroxidation, low-level chemiluminescence and regulation of secretion in the mammary gland. Experientia 49, 870–875 (1993). https://doi.org/10.1007/BF01952600
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01952600