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A marine mollusc provides the first example of in vivo storage of prostaglandins: Prostaglandin-1,15-lactones

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Summary

Prostaglandin-(PG) 1,15-lactones and, in smaller amounts, free acids, were isolated from both the mantle and the dorso-lateral appendices of the opisthobranch molluscTethys fimbria. In vivo conversion of PGs into the corresponding lactones and accumulation of PGE2- and PGE3-1,15-lactones in the appendages were shown. The detachment of these appendages from the molested mollusc caused the in vivo conversion of PGE2- and PGE3-lactones back to PGE2 and PGE3 respectively, thus providing the first example of a mechanism by which prostaglandins can be stored and, when needed, released.

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Author notes

  1. G. Sodano

    Present address: Dipartimento di Fisica, Università di Salerno, I-84081, Baronissi (SA), Italy

Authors and Affiliations

  1. Instituto per la Chimica di Molecole di Interesse Biologico del C.N.R., Via Toiano 6, I-80072, Arco Felice, Napoli, Italy

    G. Cimino, A. Crispino, V. Di Marzo, G. Sodano, A. Spinella & G. Villani

Authors
  1. G. Cimino
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  2. A. Crispino
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  3. V. Di Marzo
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  4. G. Sodano
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  5. A. Spinella
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  6. G. Villani
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Cimino, G., Crispino, A., Di Marzo, V. et al. A marine mollusc provides the first example of in vivo storage of prostaglandins: Prostaglandin-1,15-lactones. Experientia 47, 56–60 (1991). https://doi.org/10.1007/BF02041252

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  • DOI: https://doi.org/10.1007/BF02041252

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