Skip to main content
SpringerLink
Log in

Renal handling of bilirubin photoderivatives

  • Short Communications
  • Published:
Experientia Aims and scope Submit manuscript

Summary

The renal handling of unconjugated bilirubin in the dark and during light exposure was analyzed using an isolated rat kidney preparation. The parameters tested were pigment disappearance from the perfusion medium, pigment uptake by tissue, and its renal clearance. The results indicated that despite the fact that pigment disappearance from the medium was similar for both forms of pigment, the extraction ratio was higher for irradiated pigment than for pigment in the dark. When renal clearance of pigment was plotted vs pigment uptake of tissue, the results indicated that irradiated pigment may be more efficiently removed by the kidney. In addition, data on the rate of secretion of p-aminohippurate suggested that both pigment forms shared a common site for secretion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Cremer, R. J., Perryman, P.-W., and Richards, D. H., Lancet1 (1958) 1094.

    Article  CAS  PubMed  Google Scholar 

  2. Ennever, J. F., Label, M., Mc Donagh, A. F., and Speck, W. T., Pediat. Res.18 (1984) 667.

    Article  CAS  PubMed  Google Scholar 

  3. Ennever, J. F., Mc Donagh, A. J., and Speck, W. T., J. Pediat.103 (1983) 295.

    Article  CAS  PubMed  Google Scholar 

  4. Granati, B., Felice, M., Fortunato, A., Gramola, G., and Rubaltelli, F. F., Biol. Neonate43 (1983) 1.

    Article  CAS  PubMed  Google Scholar 

  5. Mc Donagh, A. F., and Lightner, D. A., Pediatrics75 (1985) 443.

    Article  Google Scholar 

  6. Mc Donagh, A. F., Palma, L. A., and Lightner, D. A., Science208 (1980) 145.

    Article  CAS  PubMed  Google Scholar 

  7. Stoll, M. S., Zenone, E. A., and Ostrow, J. D., J. clin. Invest.68 (1981) 134.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Cohen, A. N., and Ostrow, J. D., Pediatrics65 (1980) 740.

    Article  CAS  PubMed  Google Scholar 

  9. Lightner, D. A., and Mc Donagh, A. F., Acc. chem. Res.17 (1984) 417.

    Article  CAS  Google Scholar 

  10. Onishi, S., Kawade, N., Itoh, S., Isobe, K., Sugiyama, S., Hashimoto, T., and Narita, H., Biochem. J.198 (1981) 107.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Ostrow, J. D., J. clin. Invest.50 (1971) 707.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Mc Donagh, A. F., and Palma, L. A., J. clin. Invest.66 (1980) 1182.

    Article  Google Scholar 

  13. Onishi, S., Ogino, T., Yokoyama T., Isole, K., Itoh, S., Yamakawa, T., and Hashimoto, T., Biochem. J.221 (1984) 717.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Lightner, D. A., Linnane, W. P. III, and Ahlfors, Ch. E., Pediat. Res.18 (1984) 696.

    Article  CAS  PubMed  Google Scholar 

  15. Ballowitz, L., Gentler, G., Krochmann, J., Pammitschke, R., Roemer, G., and Roemer, I., Biol. Neonate31 (1977) 229.

    Article  CAS  PubMed  Google Scholar 

  16. Lightner, D. A., Wooldridge, T. A., and Mc Donagh, A. F., Biochem. Biophys. Res. Commun.86 (1979) 235.

    Article  CAS  PubMed  Google Scholar 

  17. Ennever, J. F., Knox, J., Denne, S. C., and Speck, W. T., Pediat. Res.19 (1985) 205.

    Article  CAS  PubMed  Google Scholar 

  18. Lamola, A. A., Blumberg, W. E., Mc Clead, R., and Fanaroff, A., Proc. natn. Acad. Sci. USA78 (1981) 1882.

    Article  CAS  Google Scholar 

  19. Ali, M. A. M., and Billing, B. H., Am. J. Physiol.214 (1968) 1340.

    Article  CAS  PubMed  Google Scholar 

  20. Fulop, M., and Brazeau, P., J. clin. Invest.43 (1964) 1192.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Gollan, J. L., Dallinger, K. J. C., and Billing, B. H., Clin. Sci. molec. Med.54 (1978) 381.

    CAS  Google Scholar 

  22. Elias, M. M., Comin, E. J., and Rodriguez Garay, E. A., Clin. Sci. molec. Med.53 (1977) 193.

    CAS  Google Scholar 

  23. Elias, M. M., Comin, E. J., Galeazzi, S., and Rodriguez Garay, E. A., Clin. Sci.61 (1981) 765.

    Article  CAS  Google Scholar 

  24. Elias, M. M., Comin, E. J., Ochoa, E., and Rodriguez Garay, E. A., Can. J. Physiol. Pharmac.63 (1985) 1581.

    Article  CAS  Google Scholar 

  25. Knox, J., Ennever, J. F., and Peck, W. T., Pediat. Res.19 (1985) 198.

    Article  CAS  PubMed  Google Scholar 

  26. Kapitulnik, J., Kaufmann, N. A., Goitein, K., Cividalli, G., and Blondheim, S. H., Clinica chim. acta57 (1974) 231.

    Article  CAS  Google Scholar 

  27. Ballowitz, L., Müller, W. H. W., and Wiese, G., Biol. Res. Preg5 (1984) 36.

    CAS  Google Scholar 

  28. Epstein, F. H., Brosnan, J. T., Tange, F. D., and Ross, B. D., Am. J. Physiol.243 (1982) F282.

    Google Scholar 

  29. Nelson, T., Jacobsen, J., and Wennberg, R. P., Pediat. Res.8 (1974) 963.

    Article  CAS  PubMed  Google Scholar 

  30. Lamola, A. A., Flores, J., and Blumberg, W. E., Eur. J. Biochem.132 (1983) 165.

    Article  CAS  PubMed  Google Scholar 

  31. Möller, J. V., and Iqbal Sheikh, M., Pharmac. Rev.34 (1983) 315.

    Google Scholar 

  32. Taggart, J. V., Am. J. Med.24 (1958) 774.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Instituto de Fisiologia Experimental, Universidad Nacional de Rosario, Suipacha 570, 200, Rosario, Argentina

    M. M. Elías, E. J. Comin, J. E. Ochoa & E. A. Rodríguez Garay

Authors
  1. M. M. Elías
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. J. Comin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. E. Ochoa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. A. Rodríguez Garay
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

13 August 1986

Acknowledgments. This work was supported by grants from Consejo Nacional de Investigaciones Cientificas y Técnicas (CONICET), República Argentina. The valuable technical assistance of J. Pellegrino and E. Luque is gratefully acknowledged. We are also indebted to Dr S. Bravlavsky (Max-Planck Institut für Strahlenchemie, D-4330 Mülheim a. d. Ruhr, FRG) for stimulating discussion, and to Mr B. Leguizamón for secretarial assistance.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Elías, M.M., Comin, E.J., Ochoa, J.E. et al. Renal handling of bilirubin photoderivatives. Experientia 43, 875–878 (1987). https://doi.org/10.1007/BF01951646

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01951646

Key words

Search

Navigation