Summary
An exploratory study was made of the mechanisms underlying the toxic action of carbadox in young pigs: dehydration, loss of appetite and at autopsy seemingly specific and selective structural alterations of the glomerular zone of the adrenal cortex. Administration of carbadox in the feed, in dosages of 150 ppm (approximately 6 mg·kg−1 b.wt·day−1) caused a rapid decline in the plasma aldosterone levels (to 10% of control) followed by significant changes in the sodium and potassium levels in blood. Characteristic for the toxic action of carbadox are the rapid and seemingly selective and specific alterations in the aldosterone-releasing zona glomerulosa of the adrenals. Our results indicate that with carbadox a functional and possibly reversible extirpation of the adrenal zona glomerulosa can be achieved in pigs.
This is a preview of subscription content, log in via an institution to check access.
References
Molen, E. J. van der, Nabuurs, M. J. A., and Jager, L. P., Zentbl. VetMed. A32 (1985) 540.
Guyton, A. C., Textbook of Medical Physiology, 5th edn, p. 435. Saunders, Philadelphia 1981.
Guyton, A. C., Textbook of Medical Physiology, 5th edn, p. 944. Saunders, Philadelphia 1981.
Wenting, G. J., Man In't Veld, A. J., Woittiez, A. J., Boomsa, F., Laird-Meeter, K., Simoons, M. L., Hugenholtz, P. G., and Schalekamp, M. A. D. H., Br. Heart J.49 (1983) 65.
Bayard, F., Cooke, C. R., Tiller, D. J., Beitins, I. Z., Kowarski, A., Walker, W. G., and Migeon, C. J., J. clin. Invest.50 (1971) 1585.
Giurgea, R., Borsa, M., and Ilyœs, I., Archs exp. vet. Med.30 (1976) 861.
Pfizer, Technical Report No. 8307. Pfizer Int. Inc., New York 1983.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
van der Molen, E.J., de Graaf, G.J., Spierenburg, T.J. et al. Hypoaldosteronism in piglets induced by carbadox. Experientia 42, 1247–1249 (1986). https://doi.org/10.1007/BF01946407
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01946407