Summary
The initial plasma glucose concentration of unanesthetized calves with cut splanchnic nerves, given 2-deoxyglucose (1.2 mmoles/kg, i.v.), was either lowered by prior starvation, or raised by a continuous infusion of exogenous glucose. Raising the initial plasma glucose concentration completely suppressed the release of pancreatic glucagon and pancreatic polypeptide but substantially enhanced the release of insulin in response to 2-deoxyglucose.
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References
S.R. Bloom, A.V. Edwards and R.N. Hardy, J. Physiol.280, 9 (1978).
S.R. Bloom, A.V. Edwards and J. Järhult, J. Physiol.308, 29 (1980).
S.R. Bloom and A.V. Edwards, J. Physiol.314, 23 (1981).
S.R. Bloom and A.V. Edwards, J. Physiol.315, 31 (1981).
V.S. Waravdekar, and L.D. Saslaw, J. biol. Chem.234, 1945 (1959).
R. Assan and N. Slusher, Diabetes21, 843 (1972).
J.D.M. Albano, R.P. Ekins, G. Maritz, and R.C. Turner, Acta endocr., Copenh.70, 487 (1972).
T.E. Adrian, S.R. Bloom, M.G. Bryant, J.M. Polak, P.A. Heitz and A.J. Barnes, Gut17, 940 (1976).
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This work has been supported by the Medical Research Council and the Leverhulme Trust. We are also indebted to Mr P.M.M. Bircham and Mr G.P. Macgregor for their skilled technical assistance.
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Edwards, A.V., Bloom, S.R. The glucose dependence of pancreatic endocrine responses to 2-deoxyglucose in the calf. Experientia 38, 815–816 (1982). https://doi.org/10.1007/BF01972289
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DOI: https://doi.org/10.1007/BF01972289