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Analgesic dipeptide, L-Tyr-D-Arg (D-kyotorphin) induces Met-enkephalin release from guinea-pig striatal slices

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Summary

Kyotorphin (L-Tyr-L-Arg), an analgesic dipeptide isolated from the bovine brain, and its analogue, L-Tyr-D-Arg (D-kyotorphin), have a naloxone-reversible analgesic effect. Both peptides (10−5 M) induced an approximately 4-fold increase of the basal release of Met-enkephalin from striatal slices. Therefore they may produce their analgesic effects through release of Met-enkephalin. The stronger in vivo effect of D-kyotorphin may be explained by its resistance to degradation.

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, 606, Kyoto, Japan

    H. Takagi, H. Shiomi, Y. Kuraishi & H. Ueda

Authors
  1. H. Takagi
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  2. H. Shiomi
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  3. Y. Kuraishi
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  4. H. Ueda
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Additional information

Acknowledgment. We thank M. Ohara of Kyushu University for comments on the manuscript.

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Takagi, H., Shiomi, H., Kuraishi, Y. et al. Analgesic dipeptide, L-Tyr-D-Arg (D-kyotorphin) induces Met-enkephalin release from guinea-pig striatal slices. Experientia 38, 1344–1345 (1982). https://doi.org/10.1007/BF01954941

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  • DOI: https://doi.org/10.1007/BF01954941

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