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Abnormal development of cultured rat embryos in rat and human sera prepared after vitamin A ingestion

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Summary

Human and rat sera were assayed for teratogenic activity using a whole rat embryo culture technique. Sera prepared from blood withdrawn 1–5 h after the ingestion of vitamin A capsules caused developmental retardation and craniofacial abnormalities. Control sera permitted normal growth and differentiation.

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Authors and Affiliations

  1. Physiological Laboratory, CB23EG, Cambridge, England

    C. E. Steele, J. D. Plenefisch & N. W. Klein

  2. Department of Animal Genetics, and Genetics and Cell Biology Section, University of Connecticut, 06268, Storrs, Connecticut, USA

    C. E. Steele, J. D. Plenefisch & N. W. Klein

Authors
  1. C. E. Steele
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  2. J. D. Plenefisch
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  3. N. W. Klein
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Additional information

Financial support for this project was provided by Department of Energy contract EVO 3139 (Office of Health and Environmental Research), USA (Scientific contribution 940, Storrs Agricultural Experiment Station), and by the Medical Research Council, U.K.

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Steele, C.E., Plenefisch, J.D. & Klein, N.W. Abnormal development of cultured rat embryos in rat and human sera prepared after vitamin A ingestion. Experientia 38, 1237–1239 (1982). https://doi.org/10.1007/BF01959762

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  • DOI: https://doi.org/10.1007/BF01959762

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