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Biliary excretion of sulfobromophthalein in isolated perfused livers from normal and spironolactone-treated rats

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Summary

Bile flow and biliary excretion of sulfobromophthalein (BSP) was examined in isolated perfused livers from normal and spironolactone(SP)-treated rats. BSP biliary excretion contributed to the bile production in both groups. Moreover SP increased BSP biliary excretion but transfer of dye from plasma into liver was not affected.

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Authors and Affiliations

  1. Departamento de Fisiología, Facultad de Ciencias Bioquímicas, Universidad Nacional de Rosario, Suipacha 531, 2000, Rosario, Argentina

    J. M. Pellegrino, A. D. Mottino, J. V. Rodriguez & E. A. Rodriguez Garay

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  1. J. M. Pellegrino
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  2. A. D. Mottino
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  3. J. V. Rodriguez
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  4. E. A. Rodriguez Garay
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Additional information

Acknowledgments. This work was supported by a grant from Consejo Nacional de Investigaciones Científicas y Técnicas República Argentina (EFIHER-CONICET). Isolated rat liver preparations were performed by Miss Graciela Patricia Rodriguez. The assistance of Carlos Guillermo Grieve is also gratefully acknowledged.

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Pellegrino, J.M., Mottino, A.D., Rodriguez, J.V. et al. Biliary excretion of sulfobromophthalein in isolated perfused livers from normal and spironolactone-treated rats. Experientia 38, 112–114 (1982). https://doi.org/10.1007/BF01944559

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