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Effect of abrupt withdrawal of chronically administered β-blocking drugs on cardiac sensitivity in the rat

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Summary

Increased tachycardia to isoprenaline was observed in pithed rats 2 days after withdrawal of propanolol but not after withdrawal of atenolol (a cardioselective drug) or LL 21-945 (a long acting beta-blocking drug).

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Authors and Affiliations

  1. Department of Pharmacology, Basic Medical Sciences Group, Chelsea College, University of London, Manresa Road, SW3 6LX, London, (England)

    J. H. Botting & P. Crook

Authors
  1. J. H. Botting
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  2. P. Crook
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Additional information

Acknowledgments. We are grateful to Sandoz Ltd for a gift of LL 21-943 and to I.C.I. for gifts of propranolol and atenolol.

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Botting, J.H., Crook, P. Effect of abrupt withdrawal of chronically administered β-blocking drugs on cardiac sensitivity in the rat. Experientia 37, 1320–1322 (1981). https://doi.org/10.1007/BF01948385

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  • DOI: https://doi.org/10.1007/BF01948385

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