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Reaction of pyridoxal-5′-phosphate with γ-carboxyglutamic acid

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An Erratum to this article was published on 01 December 1980

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Summary

Pyridoxal-5′-phosphate (PLP) reacts with γ-carboxyglutamic acid (Gla) to form a stable complex absorbing at 325 nm. It is suggested that a condensation occurs in which the formyl group of PLP reacts with the α-amino group and the γ carbon atom of Gla to give a pyrrolidine derivative.

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Authors and Affiliations

  1. Institute of Biological Chemistry, University of Rome and Centro di Biologia Molecolare, C.N.R., I-00185, Rome, Italy

    Laura Pecci, S. Duprè, A. Antonucci & D. Cavallini

Authors
  1. Laura Pecci
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  2. S. Duprè
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  3. A. Antonucci
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  4. D. Cavallini
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Pecci, L., Duprè, S., Antonucci, A. et al. Reaction of pyridoxal-5′-phosphate with γ-carboxyglutamic acid. Experientia 36, 910–911 (1980). https://doi.org/10.1007/BF01953787

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  • DOI: https://doi.org/10.1007/BF01953787

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