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Protracted analgesia in young and adult rats maternally exposed to methadone

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Summary

The analgesic response to the hot-plate test was studied in 21-, 45-, 60-, 120- and 300-day-old rats maternally exposed to methadone (5 mg/kg). An elevation in nociceptive threshold, in the absence of further exposure to methadone, was observed in young and adult rats perinatally subjected to methadone.

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This research was supported by grant DA 01618.

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Zagon, I.S., McLaughlin, P.J. Protracted analgesia in young and adult rats maternally exposed to methadone. Experientia 36, 329–330 (1980). https://doi.org/10.1007/BF01952306

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