Skip to main content
Log in

Inhibition ofα-chymotrypsin by 2-halogeno-ethanols; comparison with 2-methyl-ethanols and urea

  • Specialia
  • Published:
Experientia Aims and scope Submit manuscript

Summary

2-Halogeno- and 2-methyl-ethanols inhibitα-chymotrypsin in the order of their substituted groups: [1] tri>di->mono-, [2] Br->Cl->CH3->F-. The inhibition by the halogeno-ethanols is mediated differently from that by the methyl-ethanols, ethanol, and urea.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. C. Tanford, Adv. Protein Chem.23, 122 (1968).

    Google Scholar 

  2. H.F. Bundy, Analyt. Biochem.3, 431 (1962).

    Article  CAS  PubMed  Google Scholar 

  3. W. Kauzmann, Adv. Protein Chem.14, 1 (1959).

    Article  CAS  PubMed  Google Scholar 

  4. Y. Nozaki and C. Tanford, J. biol. Chem.238, 4074 (1963).

    Article  CAS  PubMed  Google Scholar 

  5. T.T. Herskovits, H. Jaillet and B. Gadegbeku, J. biol. Chem.245, 4544 (1970).

    Article  CAS  PubMed  Google Scholar 

  6. H. Uedaira, Bull. chem. Soc. Jap.45, 3068 (1972).

    Article  CAS  Google Scholar 

  7. A. Bondi, J. Phys. Chem.68, 441 (1964).

    Article  CAS  Google Scholar 

  8. L. Pauling, in: The Nature of The Chemical Bond, 3rd edn, chap. 3, p. 64. Cornell University Press, Ithaca, N.Y., 1960.

    Google Scholar 

  9. B.W. Matthews, P.B. Sigler, R. Henderson and D.M. Blow, Nature214, 652 (1967).

    Article  CAS  PubMed  Google Scholar 

  10. J.J. Birktoft and D.M. Blow, J. molec. Biol.68, 187 (1972).

    Article  CAS  PubMed  Google Scholar 

  11. D.M. Blow, J.J. Birktoft and B.S. Hartley, Nature221, 337 (1969).

    Article  CAS  PubMed  Google Scholar 

  12. J.L. Markley and M.A. Porubcan, J. molec. Biol.102, 487 (1976).

    Article  CAS  PubMed  Google Scholar 

  13. S. Ebina and H. Uedaira, Chem. Lett.1976, 1015.

  14. S. Ebina and H. Uedaira, Bull. chem. Soc. Jap.50, 1305 (1977).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ebina, S., Kobayashi, T. & Nagai, Y. Inhibition ofα-chymotrypsin by 2-halogeno-ethanols; comparison with 2-methyl-ethanols and urea. Experientia 35, 1011–1012 (1979). https://doi.org/10.1007/BF01949911

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01949911

Keywords

Navigation