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Influence of α-MSH and ACTH on cortical bone remodelling in hypophysectomized rats

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Summary

Hypophysectomy increases both periosteal resorption and endosteal apposition along the femur diaphysis in rat. Administration of α-MSH decreased the periosteal resorption but had no effect on the endosteal apposition. ACTH had only minor effects on the endosteum. Thus, α-MSH and ACTH, in the doses used, have different effects on cortical bone in rat. The effect of α-MSH on cortical bone could be an effect of the hormone alone or by its stimulation of other factors.

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Stenström, A., Hansson, L.I. & Thorngren, K.G. Influence of α-MSH and ACTH on cortical bone remodelling in hypophysectomized rats. Experientia 35, 132–133 (1979). https://doi.org/10.1007/BF01917922

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