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Prolactin and growth hormone releasing activity of [D-Met2, Pro5]-enkephalinamide in the rat after systemic administration

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Summary

The growth hormone (GH) and prolactin releasing (PRL) activity of [D-Met2, Pro5]-enkephalinamide (EKNH2), an opioid peptide analog with higher opiate agonist activity that morphine, was compared in the unanesthetized male rat to those of equimolar doses of morphine upon systemic injection. EKNH2 proved to be a higher PRL, but not GH, releaser than the opiate alkaloid.

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Authors and Affiliations

  1. Department of Pharmacology, University of Milan, Milan, Italy

    V. Locatelli, Daniela Cocchi, S. Bajusz, S. Spampinato & E. E. Müller

  2. Research Institute for Pharmaceutical Chemistry, Budapest, Italy

    V. Locatelli, Daniela Cocchi, S. Bajusz, S. Spampinato & E. E. Müller

  3. Institute of Pharmacology and Pharmacognosy, University of Catania, Cagliari, Italy

    V. Locatelli, Daniela Cocchi, S. Bajusz, S. Spampinato & E. E. Müller

  4. Institute of Pharmacology and Pharmacognosy, University of Cagliari, I-09100, Cagliari, Italy

    V. Locatelli, Daniela Cocchi, S. Bajusz, S. Spampinato & E. E. Müller

Authors
  1. V. Locatelli
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  2. Daniela Cocchi
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  3. S. Bajusz
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  4. S. Spampinato
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  5. E. E. Müller
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Locatelli, V., Cocchi, D., Bajusz, S. et al. Prolactin and growth hormone releasing activity of [D-Met2, Pro5]-enkephalinamide in the rat after systemic administration. Experientia 34, 1650–1651 (1978). https://doi.org/10.1007/BF02034731

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  • DOI: https://doi.org/10.1007/BF02034731

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