Summary
In the isolated frog or rat spinal cord, low concentrations of Mg2+ (0.5–1.00 mM) markedly depress, in a substantially Ca2+-independent manner, ventral root depolarizations produced by dorsal root stimulation and by certain amino acids (e. g. N-methyl-D-aspartate and L-homocysteate) but do not depress depolarizations produced by other excitatory amino acids (e. g. kainate and quisqualate). L-Aspartate-induced depolarizations are more sensitive to Mg2+ then are L-glutamate-induced depolarizations.
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Acknowledgment. We thank D. J. Oakes for skilled technica assistance. This work was supported by the Medical Research Council.
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Evans, R.H., Francis, A.A. & Watkins, J.C. Selective antagonism by Mg2+ of amino acid-induced depolarization of spinal neurones. Experientia 33, 489–491 (1977). https://doi.org/10.1007/BF01922227
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DOI: https://doi.org/10.1007/BF01922227