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Methadone and brain development

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Summary

The effect of maternally administered methadone hydrochloride (5 mg/kg) on brain development of off-spring treated during gestation and/or lactation was studied in 21-day-old rats. Animals treated during gestation or lactation were the most severely affected, with reductions in brain weights (12% and 30%,respectively), and DNA values (50% and 34%, respectively) observed.

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Authors and Affiliations

  1. Department of Anatomy, The Milton S. Hershey Medical Center, 17033, Hershey, Pennsylvania, USA

    I. S. Zagon & Patricia J. McLaughlin

Authors
  1. I. S. Zagon
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  2. Patricia J. McLaughlin
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Additional information

The assistance of Eileen J. Zagon is gratefully acknowledged. This research was supported in part by American Cancer Society grant PDT-27B and NIDP grant DA01618-01.

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Zagon, I.S., McLaughlin, P.J. Methadone and brain development. Experientia 33, 1486–1487 (1977). https://doi.org/10.1007/BF01918824

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  • DOI: https://doi.org/10.1007/BF01918824

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