Summary
The effect of maternally administered methadone hydrochloride (5 mg/kg) on brain development of off-spring treated during gestation and/or lactation was studied in 21-day-old rats. Animals treated during gestation or lactation were the most severely affected, with reductions in brain weights (12% and 30%,respectively), and DNA values (50% and 34%, respectively) observed.
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G. Blinick, R. Wallach, E. Jerez and B. Ackerman, Am. J. Obstet. Gynec.125, 135 (1976).
R. Ting, A. Keller and L. Finnegan, Proc. 2nd natl Drug Abuse Conf. (1975).
G. Wilson, Addict. Dis.2, 333 (1975).
W. F. Geber and L. C. Schramm, Am. J. Obstet. Gynec.123, 705 (1975).
A. Jurand, J. Embryol. expl Morph.30, 449 (1973).
M. Crofford and A. Smith, Science181, 947 (1973).
I. S. Zagon and P. J. McLaughlin, Biol. Neonate31, 271 (1977).
I. S. Zagon and P. J. McLaughlin, Expl Neurol.56, 538 (1977).
W. Schneider, J. biol. Chem.161, 293 (1945).
K. Burton, Biochem. J.62, 315 (1956).
J. Dobbing and J. Sands, Brain Res.17, 115 (1970).
J. Altman, in: Developmental Neurobiology, p. 197. Ed. W. A. Himwich. C. C. Thomas, Springfield, III. 1970.
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The assistance of Eileen J. Zagon is gratefully acknowledged. This research was supported in part by American Cancer Society grant PDT-27B and NIDP grant DA01618-01.
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Zagon, I.S., McLaughlin, P.J. Methadone and brain development. Experientia 33, 1486–1487 (1977). https://doi.org/10.1007/BF01918824
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DOI: https://doi.org/10.1007/BF01918824