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Increased aggression in rats after withdrawal of long term used oxazepam

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Summary

The withdrawal of oxazepam (5 mg/kg i.p.) applied for 1 year in rats, increased shock-induced aggression of animals. This phenomenon is interpreted as a sign of abstinence and suggests that long-term treatment causes dependence to oxazepam in rats.

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Authors and Affiliations

  1. Department of Pharmacology, Biological Physiological Institute, Silesian School of Medicine, PL-41-808, Zabrze, Poland

    Z. S. Herman, A. Drybański & H. I. Trzeciak

Authors
  1. Z. S. Herman
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  2. A. Drybański
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  3. H. I. Trzeciak
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Additional information

Acknowledgment. Authors express their gratitude to Polfa, Warszawa, for the generous supply of oxazepam.

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Herman, Z.S., Drybański, A. & Trzeciak, H.I. Increased aggression in rats after withdrawal of long term used oxazepam. Experientia 32, 1305–1306 (1976). https://doi.org/10.1007/BF01953107

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  • DOI: https://doi.org/10.1007/BF01953107

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