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Local α-adrenoceptor mediated feed-back inhibition of catecholamine release from the adrenal medulla?

  • Pharmacologica
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Zusammenfassung

Der Einfluss von Desipramin, Oxymetazolin, Phentolamin und Phenoxybenzamin auf die durch 40 mM Kalium hervorgerufene Abgabe von Katecholaminen aus isoliert perfundierten Rindernebennieren wurde untersucht. Desipramin, Oxymetazolin und Phentolamin bewirkten keine Änderung; 10−5 M Phenoxybenzamin erhöhte die Freisetzung. Dies deutet auf eine durch α-Adrenoceptoren vermittelte Rückkopplungshemmung der Freisetzung von Katecholaminen, ähnlich der an noradrenergen Nerven.

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Authors and Affiliations

  1. Pharmakologisches Institut, Universitäts-Klinikum Essen, Hufelandstrasse 55, D-4300, Essen, Federal Republic of Germany

    K. Starke, B. -D. Görlitz, H. Montel & H. J. Schümann

Authors
  1. K. Starke
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  2. B. -D. Görlitz
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  3. H. Montel
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  4. H. J. Schümann
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Additional information

We are grateful to MissE. M. Betzinger and MissI. Müller for skilful technical assistance. This work was supported by the Deutsche Forschungsgemeinschaft.

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Starke, K., Görlitz, B.D., Montel, H. et al. Local α-adrenoceptor mediated feed-back inhibition of catecholamine release from the adrenal medulla?. Experientia 30, 1170–1172 (1974). https://doi.org/10.1007/BF01923671

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