Skip to main content
SpringerLink
Log in

Action inhibitrice du thiouracil sur la carotine

  • Kurze Mitteilungen
  • Published:
Experientia Aims and scope Submit manuscript

Summary

White rats submitted to a purified diet without vitamin A develop normally with carotene. When these animals are treated with thiouracil they show trophic alterations analogous to these observed in animals submitted to a diet without vitamine or provitamine A. These disturbances are cured immediately when vitamine A or powdered thyroids are given; on the other hand they continue when the dose of carotene is augmented. Iodine too exercises a protective and curative effect with an antagonistic action to thiouracil.

The authors interpret these disturbances as due to an inhibition of the carotinase produced by thiouracil.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. Canadell etValdecasas, Med. Clin. (Barcelona)7, 44 (1946).

    Google Scholar 

  2. Nous sommes redevables aux représentants en Espagne de J. R. Geigy S.A., Bâle (Suisse) du méthyl-thiouracil employé dans ces expériences.

  3. Von Fellenberg etGrüter, Bioch. Z.42, 253 (1932).

    Google Scholar 

  4. Fasold etHeidemann, Z. ges. exper. Med.92, 53 (1935).

    Article  Google Scholar 

  5. Wendt, Münch. med. Wschr.82, 1679 (1935).

    CAS  Google Scholar 

  6. Schneider etWidmann, Klin. Wschr.14, 1786 (1945).

    Article  Google Scholar 

  7. Wohl etFeldmann, Endocrinology24, 389.

  8. Wendt, Klin. Wschr.14, 9 (1935).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire de Pharmacologie de l'Université de Barcelone, Spain

    J. M. Canadell M.D. & F. G. Valdecasas M. D.

Authors
  1. J. M. Canadell M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. G. Valdecasas M. D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Canadell, J.M., Valdecasas, F.G. Action inhibitrice du thiouracil sur la carotine. Experientia 3, 35–36 (1947). https://doi.org/10.1007/BF02155122

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02155122

Search

Navigation