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Reduced fertility in male mice following treatment with niridazole

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Zusammenfassung

Nach einmaliger i.p.-Injetion von 700 mg/kg Niridazol wurden männiiche Mäuse wiederholt mit unbehandelten Weibchen wöchentlich über 2 Monate hinweg gepaart und die Ova gesammelt. Es konnte eine starke Herabsetzung der Befruchtungsraten 3–4 Wochen nach Paarung festgestellt werden, was die Annahme einer Wirkung auf die meiotische Teilung der Spermatozyten und Spermatiden nahelegt. Nach der 7. Woche trat eine Normalisierung der Fruchtbarkeitsrate ein.

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Authors and Affiliations

  1. National Cancer Institute, National Institutes of Health, Bethesda, Maryland

    S. R. Joshi, Y. Bishop &  S. S. Epstein (Director Environmental Helth Programs)

  2. Children's Cancer Research Foundation, Boston, Massachusetts

    S. R. Joshi, Y. Bishop &  S. S. Epstein (Director Environmental Helth Programs)

  3. Dept of Pharmacology, Case Western Reserve University Medical School, 44106, Cleveland, Ohio, USA

    S. R. Joshi, Y. Bishop &  S. S. Epstein (Director Environmental Helth Programs)

  4. Case Western Reserve University Medical School, 44106, Cleveland, Ohio, USA

    S. S. Epstein (Director Environmental Helth Programs)

Authors
  1. S. R. Joshi
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  2. Y. Bishop
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  3. S. S. Epstein
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Additional information

This work was supported by NIH Grants No. C-6516 and No. FR 05526 and by the Environmental Protection Agency Contract No. CPA-70-17.

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Joshi, S.R., Bishop, Y. & Epstein, S.S. Reduced fertility in male mice following treatment with niridazole. Experientia 29, 1253–1255 (1973). https://doi.org/10.1007/BF01935103

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  • DOI: https://doi.org/10.1007/BF01935103

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