Summary
Skeletal defects were observed in the off-spring of SWS-mice following i.p. administration of phthaloyl-l-glutamic acid, a metabolite of thalidomide. The fetuses of animals which receivedl-glutamic acid in addition to the teratogenic drug, did not show any malformations, whereas concurrent i.p. administration of thed-isomer of glutamic acid failed to reverse teratogenicity induced by phthaloyl-l-glutamic acid.
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Köhler, F., Ockenfels, H. Kompensation der teratogenen Wirkung eines Thalidomid-Metaboliten durchl-Glutaminsäure. Experientia 27, 421–422 (1971). https://doi.org/10.1007/BF02137287
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DOI: https://doi.org/10.1007/BF02137287