Summary
Direct intranuclear inclusions appearing in convoluted tubules in kidneys of white rats after a chronic lead intoxication do not participate in synthesis or migration of RNA and protein, which was demonstrated by autoradiography following an injection of3H-cytidine or3H-l-phenylalanine. The synthetic activity for RNA and protein increases impressively in the residual karyoplasm. Intranuclear inclusions neither disturb modus and velocity of RNA migration from nucleolus and karyoplasm into cytoplasm, nor impair cytoplasmic protein metabolism.
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Mit Unterstützung des Bundesministeriums für Wissenschaftliche Forschung
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Stöcker, E., Robke, K. & Müller, H.A. Autoradiographische Untersuchungen an «direkten» Kerneinschlüssen im Nierenepithel der Ratte nach Bleivergiftung. Experientia 23, 558 (1967). https://doi.org/10.1007/BF02137968
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DOI: https://doi.org/10.1007/BF02137968