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New Amphenone analogs as adrenocortical inhibitors

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Zusammenfassung

2-Methyl-1,2-bis-(3-pyridyl)-1-propanon (Su 4885) hemmt beim Hund die Ausscheidung von 17-OH-Steroiden aus den Nebennieren und hemmtin vitro ähnlich wie Amphenon den ACTH-Effekt auf Ratten-, Meerschweinchen-und Hunde-Nebennieren.In situ bei der Ratte hat es jedoch keine Amphenon-Wirkung, von dem es sich auch sonst unterscheidet.

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References

  1. M. J. Allen andA. H. Corwin, J. Amer. chem. Soc.72, 117 (1950).

    Article  CAS  Google Scholar 

  2. W. L. Bencze andM. J. Allen, J. organ. Chem.22, 352 (1957).

    Article  CAS  Google Scholar 

  3. J. Korman andE. C. Olson, J. organ. Chem.22, 870 (1957).

    Article  CAS  Google Scholar 

  4. M. J. Allen, R. Hertz, andW. W. Tullner, Proc. Soc. exp. Biol. Med.74, 632 (1950).

    Article  CAS  PubMed  Google Scholar 

  5. R. Hertz, M. J. Allen, andW. W. Tullner, Proc. Soc. exp. Biol. Med.75, 627 (1950).

    Article  CAS  PubMed  Google Scholar 

  6. R. Hertz, W. W. Tullner, andM. J. Allen, Proc. Soc. exp. Biol. Med.77, 480 (1951).

    Article  CAS  PubMed  Google Scholar 

  7. R. Hertz, M. J. Allen, W. W. Tullner, andB. B. Westfall, Proc. Soc. exp. Biol. Med.79, 42 (1952).

    Article  CAS  PubMed  Google Scholar 

  8. A. E. Heming, D. E. Holtkamp, J. F. Kerwin, L. F. Mansor, andJ. G. Decanay, Proc. Soc. exp. Biol. Med.80, 154 (1952).

    Article  CAS  PubMed  Google Scholar 

  9. J. R. Hogness, R. H. Williams, andM. Lance, Proc. Soc. exp. Biol. Med.79, 43 (1952).

    Article  CAS  PubMed  Google Scholar 

  10. R. Hertz, W. W. Tullner, J. A. Schricker, F. G. Dhyse, andL. F. Hallman,Recent Progress in Hormone Research, vol. 11 (New York 1955), p. 119.

  11. W. W. Tullner, M. M. Graff, andR. Hertz, Endocrinology58, 802 (1956).

    Article  CAS  PubMed  Google Scholar 

  12. R. Hertz, J. A. Pittman, andM. M. Graff, J. clin. Endocrinol. Metab.16, 705 (1956).

    Article  CAS  PubMed  Google Scholar 

  13. G. W. Thorn, A. E. Renold, A. Goldfien, D. H. Nelson, W. J. Reddy, andR. Hertz, New England J. Med.254, 547 (1956).

    Article  CAS  Google Scholar 

  14. A. E. Renold, J. Crabbe, L. Hernando-Avendano, D. H. Nelson, E. J. Ross, K. Emerson, Jr., andG. W. Thorn, New England J. Med.256, 16 (1957).

    Article  Google Scholar 

  15. R. S. Mach andA. F. Müller, Schweiz. med. Wschr. Supplement14, 406 (1957).

    Google Scholar 

  16. M. J. Allen, J. organ. Chem.15, 435 (1950).

    Article  CAS  Google Scholar 

  17. D. M. Hume andD. H. Nelson,Surgical Forum (40th), Clin. Congress Amer. College Surgeons (Philadelphia, 1955).

  18. R. H. Silber andR. D. Busch, J. clin. Endocrinol. Metab.16, 1333 (1956).

    Article  CAS  PubMed  Google Scholar 

  19. J. Nichols andH. L. Sheehan, Endocrinology51, 362 (1952).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Research Department, CIBA Pharmaceutical Products Inc., Summit, N. J.

    J. J. Chart, H. Sheppard, M. J. Allen, W. L. Bencze & R. Gaunt

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  1. J. J. Chart
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  2. H. Sheppard
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  3. M. J. Allen
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  4. W. L. Bencze
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  5. R. Gaunt
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Chart, J.J., Sheppard, H., Allen, M.J. et al. New Amphenone analogs as adrenocortical inhibitors. Experientia 14, 151–152 (1958). https://doi.org/10.1007/BF02157133

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  • DOI: https://doi.org/10.1007/BF02157133

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