1932
0
  1. Home
  2. A-Z Publications
  3. Annual Review of Genomics and Human Genetics
  4. Volume 3, 2002
  5. Article

Annual Review of Genomics and Human Genetics

Volume 3, 2002

A Personal History of the Mouse Genome

Abstract

The chapter describes some personal reminiscences of various stages in the growth of knowledge of the mouse genome in the past 50 years. Initially mapping was done by crossing new mutants with linkage testing stocks, a slow and laborious method. In the 1950s major mutagenesis experiments led to spin-offs in terms of new mutants, new knowledge of phenomena including sex determination and X-chromosome inactivation, and further understanding of the -complex. The 1970s saw the development of recombinant inbred (RI) strains and the use of biochemical variants for mapping. In addition the linkage groups were assigned to chromosomes. Techniques of embryo surgery were developed, leading to work with embryonic stem (ES) cells and hence to the identification of gene functioning by knockouts and transgenesis. Another major advance in the 1970s and 1980s was the beginning of comparative mapping, which is now so important. With the advent of DNA technology, progress in mapping increased considerably. Progress became even faster with the use of interspecific backcrosses and with the development of microsatellite markers. The completion of the mouse DNA sequence is now imminent, opening fascinating prospects for the analysis of gene function.

Keyword(s): autobiography, genetic mapping, genome analysis, mouse genetics, women in science
Loading

Article metrics loading...

/content/journals/10.1146/annurev.genom.3.021202.150353
2002-09-01
2024-04-26
Loading full text...

Full text loading...

/deliver/fulltext/genom/3/1/annurev.genom.3.021202.150353.html?itemId=/content/journals/10.1146/annurev.genom.3.021202.150353&mimeType=html&fmt=ahah

Literature Cited

  1. Avner P, Amar L, Dandolo L, Guénet J-L. 1988. Genetic analysis of the mouse using interspecific crosses.. Trends Genet. 4:18–23 [Google Scholar]
  2. Bailey DW. 1971. Recombinant inbred strains, an aid to finding identity, linkage, and function of histocompatibility and other genes.. Transplantation 11:325–27 [Google Scholar]
  3. Barlow DP, Stoger R, Herrmann BG, Saito K, Schweifer N. 1991. The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus.. Nature 349:84–87 [Google Scholar]
  4. Barr ML, Bertram EG. 1949. A morphological distinction between neurons of the male and female, and the behaviour of the nucleolar satellite during accelerated nucleoprotein synthesis.. Nature 163:676–77 [Google Scholar]
  5. Bonhomme F, Benmedhi F, Britton-Davidian J, Martin S. 1979. Analyse génétique de croisements interspécifiques Mus musculus L, x Mus spretus Lataste: liason de Adh-l avec Amy-1 sur le chromosome 3 et de Es-14 avec Mod-1 sur le chromosome 9.. Contes Rendues Acad. Sci. Paris 289:545–48 [Google Scholar]
  6. Boyd Y, Blair HJ, Cunliffe P, Masson WK, Reed V. 2000. A phenotype map of the mouse X chromosome: models for human X-linked disease.. Genome Res. 10:277–92 [Google Scholar]
  7. Buckle VJ, Edwards JH, Evans EP, Jonasson JA, Lyon MF. et al. 1985. Comparative maps of human and mouse X chromosomes.. Cytogenet. Cell Genet. 40:594–95 [Google Scholar]
  8. Carter TC, Falconer DS. 1951. Stocks for detecting linkage in the mouse and the theory of their design.. J. Genet. 50:307–23 [Google Scholar]
  9. Carter TC, Lyon MF, Phillips RJS. 1955. Gene-tagged chromosome translocations in eleven stocks of mice.. J. Genet. 53:154–66 [Google Scholar]
  10. Cattanach BM, Kirk M. 1985. Differential activity of maternally and paternally derived chromosome regions in mice.. Nature 315:496–98 [Google Scholar]
  11. Clerc P, Avner P. 1998. Role of the region 3′ to Xist exon 6 in the counting process of X-chromosome inactivation.. Nat. Genet. 19:249–53 [Google Scholar]
  12. Copeland NG, Jenkins NA, Gilbert DJ, Eppig JT, Maltais LG. et al. 1993. A genetic linkage map of the mouse: current applications and future prospects.. Science 262:57–66 [Google Scholar]
  13. Davisson MT, Roderick TH. 1979. Linkage map of the mouse.. Mouse News Lett. 61:19 [Google Scholar]
  14. Dobrovolskaia-Zavadskaia N. 1927. Sur la mortification spontanée de la queue chez la souris nouveau-née et sur l'existence d'un caractère (facteur) héréditaire “non-viable.”. Contes Rendues Soc. Biol. (Paris) 97:114–16 [Google Scholar]
  15. Dobrovolskaia-Zavadskaia N, Kobozieff N. 1932. Les souris anoures et à queue filiforme qui se reproduisent entre elles sans disjonction.. Contes Rendues Soc. Biol. (Paris) 110:782–84 [Google Scholar]
  16. Doolittle DP, Davisson MT, Guidi JN, Green MC. 1996. Catalogue of mutant genes and polymorphic loci.. See Ref. 55 17–854
  17. Dunn LC, Grüneberg H, Snell GD. 1940. Report of the committee on mouse genetics nomenclature.. J. Hered. 31:505–6 [Google Scholar]
  18. Edwards JH. 1991. The Oxford grid.. Ann. Hum. Genet. 55:17–31 [Google Scholar]
  19. Eicher EM. 1971. The identification of the chromosome bearing linkage group XII in the mouse.. Genetics 69:267–71 [Google Scholar]
  20. Eicher EM. 1981. Foundation for the future: formal genetics of the mouse. In Mammalian Genetics and Cancer: The Jackson Laboratory Fiftieth Anniversary Symposium, ed. ES Russell 7–49 New York: AR Liss
  21. Erway LC, Fraser AS, Hurley LS. 1971. Prevention of congenital otolith defect in pallid mutant mice by manganese supplementation.. Genetics 67:97–108 [Google Scholar]
  22. Evans EP, Lyon MF, Daglish M. 1967. A mouse translocation giving a metacentric marker chromosome.. Cytogenetics 6:105–19 [Google Scholar]
  23. Evans MJ, Kaufman MH. 1981. Establishment in culture of pluripotential cells from mouse embryos.. Nature 292:154–56 [Google Scholar]
  24. Falconer DS. 1953. Total sex linkage in the house mouse.. Z. Indukt. Abstammungs-Vererbungsl 85210–19
  25. Fox HS, Martin GR, Lyon MF, Herrmann B, Frischauf A-M. et al. Molecular probes define different regions of the mouse t-complex.. Cell 40:63–69 [Google Scholar]
  26. Fraser AS, Sobey S, Spicer CC. 1953. Mottled, a sex-modified lethal in the house mouse.. J. Genet. 51:217–21 [Google Scholar]
  27. Gardner RL. 1968. Mouse chimaeras obtained by the injection of cells into the blastocyst.. Nature 220:596–97 [Google Scholar]
  28. Gardner RL. 1998. Contributions of blastocyst micromanipulation to the study of mammalian development.. BioEssays 20:168–80 [Google Scholar]
  29. Gardner RL, Lyon MF. 1971. X-chromosome inactivation studied by injection of a single cell into the mouse blastocyst.. Nature 231:385–86 [Google Scholar]
  30. Green EL. 1978. A brief autobiography relative to work with inbred and mutant mice.. See Ref. 62 167–78
  31. Green MC. 1963. Methods for testing linkage. In Methodology in Mammalian Genetics, ed. WJ Burdette 56–82 San Francisco: Holden-Day Inc
  32. Green MC. 1978. Brief autobiography related to work on inbred mice.. See Ref. 62 157–65
  33. Green MC. ed 1981. Genetic Variants and Strains of the Laboratory Mouse. Stuttgart: Gustav Fischer 476 pp. [Google Scholar]
  34. Groot PC, Moen CJA, Hart AAM, Snoek M, Demant P. 1996. Recombinant congenic strains—genetic composition.. See Ref. 55 1660–70
  35. Grüneberg H. 1943. The Genetics of the Mouse. Cambridge: Cambridge Univ. Press [Google Scholar]
  36. Grüneberg H. 1952. The Genetics of the Mouse. The Hague: Martimus Nijhoff. 2nd ed [Google Scholar]
  37. Haldane JBS, Sprunt AD, Haldane NM. 1915. Reduplication in mice.. J. Genet. 5:133–35 [Google Scholar]
  38. Hammer MF, Schimenti J, Silver LM. 1989. Evolution of mouse chromosome 17 and the origins of inversions associated with t-haplotypes.. Proc. Natl. Acad. Sci. USA 86:3261–65 [Google Scholar]
  39. Herrmann BG, Labeit S, Poustka A, King TR, Lehrach H. 1990. Cloning of the T gene required in mesoderm formation in the mouse.. Nature 343:617–22 [Google Scholar]
  40. Herrmann BG, Koschorz B, Wertz K, McLaughlin KJ, Kispert A. 1999. A protein kinase encoded by the t-complex responder gene causes non-Mendelian inheritance.. Nature 402:141–46 [Google Scholar]
  41. Huang L, Kuo Y-M, Gitschier J. 1999. The pallid gene encodes a novel, syntactin 13-interacting protein involved in platelet storage pool deficiency.. Nat. Genet. 23:329–32 [Google Scholar]
  42. Lee JT, Jaenisch R. 1997. Long-range cis effects of ectopic X-inactivation centres on a mouse autosome.. Nature 386:275–78 [Google Scholar]
  43. Love JM, Knight AM, McAleer M, Todd JA. 1990. Towards construction of a high-resolution map of the mouse genome using PCR-analysed microsatellites.. Nucleic Acids Res. 18:4123–30 [Google Scholar]
  44. Lyon MF. 1951. Hereditary absence of otoliths in the house mouse.. J. Physiol. 114:410–18 [Google Scholar]
  45. Lyon MF. 1953. Absence of otoliths in the mouse: an effect of the pallid mutant.. J. Genet. 51:638–50 [Google Scholar]
  46. Lyon MF. 1960. A further mutation of the mottled type in the house mouse.. J. Hered. 51:116–21 [Google Scholar]
  47. Lyon MF. 1961. Gene action in the X chromosome of the mouse (Mus musculus L).. Nature 190:372–73 [Google Scholar]
  48. Lyon MF. 1962. Sex chromatin and gene action in the mammalian X chromosome.. Am. J. Hum. Genet. 14:135–48 [Google Scholar]
  49. Lyon MF. 1991. The genetic basis of transmission-ratio distortion and male sterility due to the t-complex.. Am. Nat. 137:349–58 [Google Scholar]
  50. Lyon MF. 1997. A life story of Mouse News Letter and Mouse Genome.. Mouse Genome 95:818–20 [Google Scholar]
  51. Lyon MF, Cocking Y, Gao X. 1997. Mouse chromosome atlas.. Mouse Genome 95:731–88 [Google Scholar]
  52. Lyon MF, Davisson MT. 1997. Standardized mouse genetic nomenclature: past history and future perspectives.. Mouse Genome 95:840–44 [Google Scholar]
  53. Lyon MF, Meredith R. 1964. Investigations of the nature of t-alleles in the mouse.. I. Genetic analysis of a series of mutants derived from a lethal allele Heredity 19:301–12 [Google Scholar]
  54. Lyon MF, Phillips RJS. 1959. Crossing-over in mice heterozygous for t-alleles.. Heredity 13:23–32 [Google Scholar]
  55. Lyon MF, Rastan S, Brown SDM. eds 1996. Genetic Variants and Strains of the Laboratory Mouse. Oxford: Oxford Univ. Press. 3rd ed 1807 pp. [Google Scholar]
  56. Lyon MF, Searle AG. eds 1989. Genetic Variants and Strains of the Laboratory Mouse. Oxford: Oxford Univ. Press. 2nd ed 876 pp. [Google Scholar]
  57. Lyon MF, Zenthon J, Evans EP, Burtenshaw MD, Willison KR. 1988. Extent of the mouse t complex and its inversions shown by in situ hybridization.. Immunogenetics 27:375–82 [Google Scholar]
  58. Marahrens Y, Panning B, Dausman J, Strauss W, Jaenish R. 1997. Xist-deficient mice are defective in dosage compensation but not spermatogenesis.. Genes Dev. 11:156–66 [Google Scholar]
  59. McGrath J, Solter D. 1984. Completion of mouse embryogenesis requires both the maternal and paternal genomes.. Cell 37:179–83 [Google Scholar]
  60. Miller DA, Miller OJ. 1972. Chromosome mapping in the mouse.. Science 178:949–55 [Google Scholar]
  61. Miller JC, Dietrich WF, Steen RG, Joyce DC, Merchant MA. et al. 1996. SSLP/microsatellite genetic linkage map of the mouse.. See Ref. 55 1671–755
  62. Morse HC. 1978. Origins of Inbred Mice. New York: Academic 719 pp. [Google Scholar]
  63. Nadeau JH, Taylor BA. 1984. Lengths of chromosomal segments conserved since divergence of man and mouse.. Proc. Natl. Acad. Sci. USA 81:814–18 [Google Scholar]
  64. Nesbitt MN, Francke U. 1973. A system of nomenclature for band patterns of mouse chromosomes.. Chromosoma 41:145–58 [Google Scholar]
  65. Ohno S, Hauschka TS. 1960. Allocycly of the X-chromosome in tumors and normal tissues.. Cancer Res. 20:541–45 [Google Scholar]
  66. Papaioannou VE, McBurney MW, Gardner RL, Evans MJ. 1975. Fate of teratocarcinoma cells injected into early mouse embryos.. Nature 258:70–73 [Google Scholar]
  67. Penny GD, Kay GF, Sheardown SA, Rastan S, Brockdorff N. 1996. The Xist gene is required in cis for X-chromosome inactivation.. Nature 379:131–37 [Google Scholar]
  68. Röhme D, Fox H, Herrmann B, Frischauf A-M, Edstrom J-E. et al. 1984. Molecular clones of the mouse t complex derived from microdissected metaphase chromosomes.. Cell 36:783–88 [Google Scholar]
  69. Searle AG, Peters J, Lyon MF, Evans EP, Edwards JH, Buckle VJ. 1987. Chromosome maps of man and mouse III.. Genomics 1:3–18 [Google Scholar]
  70. Silver LM. 1985. Mouse t haplotypes.. Annu. Rev. Genet. 19:179–208 [Google Scholar]
  71. Silver LM. 1995. Mouse Genetics. Oxford: Oxford Univ. Press 362 pp.
  72. Silver LM, Artzt K. 1981. Recombination suppression of mouse t-haplotypes is due to chromatin mismatching.. Nature 290:68–70 [Google Scholar]
  73. Snell GD. 1928. A crossover between the genes for short-ear and density in the mouse.. Proc. Natl. Acad. Sci. USA 14:926–28 [Google Scholar]
  74. Snell GD. 1935. The induction by X-rays of hereditary changes in mice.. Genetics 20:545–67 [Google Scholar]
  75. Snell GD. 1946. An analysis of translocations in the mouse.. Genetics 31:157–80 [Google Scholar]
  76. Snell GD. 1948. Methods for the study of histocompatibility genes.. J. Genet. 49:87–108 [Google Scholar]
  77. Surani MAH, Barton SC, Norris ML. 1984. Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis.. Nature 308:548–50 [Google Scholar]
  78. Takagi N, Sasaki M. 1975. Preferential inactivation of the paternally derived X-chromosome in the extraembryonic membranes of the mouse.. Nature 256:640–41 [Google Scholar]
  79. Taylor BA. 1989. Recombinant inbred strains.. See Ref. 56 773–96
  80. Weber JL, May PE. 1989. Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.. Am. J. Hum. Genet. 44:388–96 [Google Scholar]
  81. Welshons WJ, Russell LB. 1959. The Y-chromosome as the bearer of male-determining factors in the mouse.. Proc. Natl. Acad. Sci. USA 45:560–66 [Google Scholar]
  82. Whittingham DG, Lyon MF, Glenister PH. 1977. Long-term storage of mouse embryos at −196°C: the effect of background radiation.. Genet. Res. Camb. 29:171–81 [Google Scholar]
  83. Whittingham DG, Lyon MF, Glenister PH. 1977. Re-establishment of breeding stocks of mutant and inbred strains of mice from embryos stored at −196°C for prolonged periods.. Genet. Res. Camb. 30:287–99 [Google Scholar]
  84. Willison KR, Lyon MF. 2000. A UK-centric history of studies on the mouse t-complex.. Int. J. Dev. Biol. 44:57–63 [Google Scholar]
/content/journals/10.1146/annurev.genom.3.021202.150353
Loading
  • Article Type: Review Article

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error