Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937*.

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Hohmann, C., Schneider, K., Bruntner, C., Irran, E., Nicholson, G., Bull, A.T., Jones, A.L., Brown, R., Stach, J.E.M., Goodfellow, M., Beil, W., Krämer, Marco, Imhoff, Johannes F. , Süssmuth, R.D. and Fiedler, H.-P. (2009) Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937*. Journal of Antibiotics, 62 . pp. 99-104. DOI 10.1038/ja.2008.24.

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Supplementary data:

Abstract

Caboxamycin, a new benzoxazole antibiotic, was detected by HPLC-diode array screening in extracts of the marine strain Streptomyces sp. NTK 937, which was isolated from deep-sea sediment collected in the Canary Basin. The structure of caboxamycin was determined by mass spectrometry, NMR experiments and X-ray analysis. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase.

Document Type: Article
Keywords: benzoxazole antibiotic, fermentation, Isolation, marine Streptomyces, structural elucidation
Research affiliation: OceanRep > The Future Ocean - Cluster of Excellence
OceanRep > GEOMAR > FB3 Marine Ecology > FB3-MI Marine Microbiology
Refereed: Yes
Open Access Journal?: No
Publisher: Nature Publishing Group
Projects: Future Ocean, ACTINOGEN
Date Deposited: 26 Jan 2009 10:23
Last Modified: 23 Sep 2019 18:43
URI: https://oceanrep.geomar.de/id/eprint/7997

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