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Measuring vitamins and minerals in dietary supplements for nutrition studies in the USA

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Abstract

This article illustrates the importance of having analytical data on the vitamin and mineral contents of dietary supplements in nutrition studies, and describes efforts to develop an analytically validated dietary supplement ingredient database (DSID) by a consortium of federal agencies in the USA. Preliminary studies of multivitamin mineral supplements marketed in the USA that were analyzed as candidates for the DSID are summarized. Challenges are summarized, possible future directions are outlined, and some related programs at the Office of Dietary Supplements, National Institutes of Health are described. The DSID should be helpful to researchers in assessing relationships between intakes of vitamins and minerals and health outcomes.

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References

  1. US Department of Agriculture, Agricultural Research Service, Nutrient Data Laboratory (2006) USDA Nutrient Database for Standard Reference, Release 18. In: Nutrient Data Laboratory home page. http://www.nal.usda.gov/fnic/foodcomp/search (or http://www.ars.usda.gov/nutrientdata. Cited 9 March 2007

  2. Veatch AE, Brockman JD, Spate VL, Robertson JD, Morris JS (2005) Selenium and nutrition: the accuracy and variability of the selenium content in commercial supplements. J Radioanal Nuc Chem 264:33–38

    Article  CAS  Google Scholar 

  3. Yetley E (2007) Multivitamin and multimineral dietary supplements: definitions, characterization, bioavailability and drug interactions. Am J Clin Nutr 85:269S–276S

    CAS  Google Scholar 

  4. Food and Nutrition Board, Institute of Medicine (2006) Dietary reference intakes: the essential guide to nutrient requirements. National Academy Press, Washington, DC

    Google Scholar 

  5. Moshfegh A, Goldman J, Cleveland L (2005) What we eat in America: usual nutrient intakes from food compared to dietary reference intakes. US Department of Agriculture, Agricultural Research Service, Washington, DC (see http://www.ars.usda.gov/ba/bhnrc/fsrg)

  6. Murphy SP, White KK, Park SY, Sharma S (2007) Multivitamin–multimineral supplements’ effect on total nutrient intake. Am J Clin Nutr 85:280S–284S

    CAS  Google Scholar 

  7. Rock CJ (2007) Multivitamin-multimineral supplements:who uses them? Am J Clin Nutr 85:277S–279S

    CAS  Google Scholar 

  8. Dwyer J, Picciano M, Raiten DJ (2003) Future directions for what we eat in America-NHANES: the Integrated CSFII-NHANES. J Nutr 133:575S–635S

    Google Scholar 

  9. Dwyer J, Picciano M, Raiten DJ et al (2003) Collection of food and dietary supplement intake data: what we eat in America-NHANES. J Nutr 133:575S–635S

    Google Scholar 

  10. Dwyer J, Picciano M, Raiten DJ (2003a) Estimation of usual intakes: what we eat in America-NHANES. J Nutr 133:609S–623S

    Google Scholar 

  11. Dwyer J, Picciano M, Raiten DJ (2003b) Food and dietary supplement databases for what we eat in America-NHANES. J Nutr 133:624S–634S

    Google Scholar 

  12. Office of Dietary Supplements (2003) Retrieved 2007–06–06 from the Office of Dietary Supplements Home Page: http://ods.od.nih.gov/news/conferences/Dietary_Supplement_Use_Summary.html

  13. Office of Dietary Supplements (2002) Summary of ODS Workshop; assessment of dietary supplement use: Workshop on Database Needs. http://ods.od.nih.gov/News?Workshop_Future_Directions_for_the_CSFIINHANES_Diet_Nutrition_Survey_June_20–21_2002.aspx. Cited 6 June 2007

  14. Codex Alimentarius (2006) Guidelines for vitamin and mineral food supplements. http://www.codexalimentarius.net/download/standards/10206/cxg_055e.pdf. Cited 4 July 2007

  15. European Parliament and Council (2002) Directive 2002/46/EC of the European Parliament and of the Council of 10 June 2002 on the approximation of the laws of the Member States related to food supplements. Off J Eur Commun L:51–57

    Google Scholar 

  16. Commission of the European Communities (2006) Commission directive 2006/37/EC of 30 March 2006 amending annex II to directive 2002/46/EC of the European Parliament and of the Council as regards the inclusion of certain substances. Off J Eur Union L94/32

  17. European Commission (2006) Discussion paper on the setting of maximum and minimum amounts for vitamins and minerals in foodstuffs. OIB, Brussels

  18. Saldanha L, Betz JM, Coates PM (2004) Development of the analytical methods and reference materials program for dietary supplements at the National Institutes of Health. J APAC Int 87:162–165

    CAS  Google Scholar 

  19. Betz J (2006) Botanical quality initiatives at the Office of Dietary Supplements, National Institutes of Health. In: Wang M, Sang S, Hwang L, Ho C (eds) Herbs: challenges in chemistry and biology. American Chemical Society, Washington, DC, 295:2–13

  20. Sullivan DM, Carpenter CD (eds) (1993) Methods of analysis for nutrition labeling. AOAC International, Gaithersburg, MD

  21. USP (2002) USP-26-2003. In: The official compendia of standards. United States Pharmacopeial Convention, Rockville, MD

  22. Atwater J, Montgomery-Salguero J, Roll DB (2005) The USP dietary supplement verification program: helping pharmacists and consumers select dietary supplement. US Pharmacist 6:61–64

    Google Scholar 

  23. Holden JM, Harnly J, Beecher F (2006) Food composition. In: Bowman BA, Russell RM (eds) Present knowledge in nutrition, 9th edn, vol 1. ILSI Press, Washington, DC, pp 781–794

  24. Holden JM, Harnly JM, Beecher GR (2001) Food composition. In: Russell RM, Bowman BM (eds) Present knowledge in nutrition. ILSI Press, Washington, DC, pp 593–604

    Google Scholar 

  25. Roseland J, Holden JM, Andrews KW, Zhao CW, Schweitzer A, Harnly J, Wolf W, Perry CR, Dwyer JT, Picciano MF, Betz JM, Saldanha LG, Yetley E, Fisher K, Sharpless K (2007) Dietary supplement ingredients database (DSID): preliminary USDA research studies address basic questions on composition of adult multivitamin/mineral supplements. J Food Compos Anal (in press)

  26. Dwyer J, Picciano M et al (2007) 30th National Nutrient Database Conference: progress in developing dietary supplement databases: analytically validated dietary supplement ingredients database (DSID) and dietary supplement label database (DSLD) at NIH’s office of dietary supplements. J Food Compos Anal 20 (in press)

  27. Whittaker P, Tufaro PR, Rader JI (2001) Iron and folate in fortified cereals. J Am Coll Nutr 20:247–254

    CAS  Google Scholar 

  28. Expert Group on Vitamins and Minerals (2003) Safe upper levels of vitamins and minerals. http://www.food.gov.uk/multimedia/pdfs/vitmin2003.pdf. Cited 6 June 2007

  29. Consumerlabs.com (2007) Product review: multivitamin mineral supplements. http://www.consumerlab.com/results/multivit.asp. Cited 6 June 2007

  30. FAO/WHO (2005) Report of a joint WHO/FAO technical workshop on nutrient risk assessment. A model for establishing upper levels of intake for nutrients and related substances: report of a joint FAO/WHO technical workshop on food nutrient risk assessment. World Health Organization Press, Geneva, Switzerland

    Google Scholar 

  31. Feifer AH, Fleshner NE, Klotz L (2002) Analytical accuracy and reliability of commonly used nutritional supplements in prostate disease. J Urol 168:150–154

    Article  CAS  Google Scholar 

  32. Luthria DL (2006) Perspective: significance of sample preparation in developing analytical methodologies for accurate estimation of bioactive compounds in functional foods. J Sci Food Agric 86:2266–2272

    Article  CAS  Google Scholar 

  33. National Center for Health Statistics (2007) National Health and Nutrition Examination Survey. http://www.cdc.gov/nchs/nhanes.htm. Cited 6 June 2007

  34. Radimer K, Bindewald B, Hughes J, Ervin B, Swanson C, Picciano MFl (2004) Dietary supplement use in adults in the US, 1999–2000. Am J Epidemiol 160:339–349

    Article  Google Scholar 

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Correspondence to Johanna T. Dwyer.

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Dwyer, J.T., Holden, J., Andrews, K. et al. Measuring vitamins and minerals in dietary supplements for nutrition studies in the USA. Anal Bioanal Chem 389, 37–46 (2007). https://doi.org/10.1007/s00216-007-1456-z

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  • DOI: https://doi.org/10.1007/s00216-007-1456-z

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