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A novel miniaturized extraction capillary for determining gaseous formaldehyde by high-performance liquid chromatography

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Abstract

A novel miniaturized sample extraction capillary was developed to provide a simple and sensitive method for analyzing gaseous formaldehyde (FA) using conventional high-performance liquid chromatography (HPLC). The extraction capillary was prepared by packing silica gel particles in a stainless steel capillary with a 1.6-mm o.d. Before the gaseous samples were collected, the silica gel particles were impregnated with a derivatizing reagent 2,4-dinitrophenylhydrazine (DNPH) by passing a solution of DNPH through the extraction capillary. FA was derivatized to form the corresponding hydrazone during the active sampling of a gaseous sample, and the derivative was sorbed by the silica gel. The capillary was then directly connected to a six-port valve, and desorption from the capillary and injection into the HPLC were achieved simultaneously by passing a solvent through the capillary. The run-to-run and device-to-device variabilities, as relative standard deviations, were both less than 6.9 %. The limit of detection for FA was 2.5 ng/L using a sampling volume of 100 mL, and a sample collection time of 2 min. Acetaldehyde and acetone in a gaseous sample could also be simultaneously extracted and determined using this method. The applicability of the developed method for determining FA in real indoor air samples was confirmed by comparing the results obtained using the proposed method and a conventional sample preparation method. The developed method enables the rapid and simple sample preparation of gaseous FA and gives a good level of sensitivity.

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Acknowledgments

Part of this study was financially supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS).

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Authors and Affiliations

  1. Department of Applied Chemistry, University of Yamanashi, 4-3-11 Takeda, Kofu, 400-8511, Japan

    Ikuo Ueta, Suguru Mochizuki, Susumu Kawakubo & Tetsuo Kuwabara

  2. Department of Environmental and Life Sciences, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, 441-8580, Japan

    Kiyokatsu Jinno & Yoshihiro Saito

Authors
  1. Ikuo Ueta
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  2. Suguru Mochizuki
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  3. Susumu Kawakubo
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  4. Tetsuo Kuwabara
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  5. Kiyokatsu Jinno
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  6. Yoshihiro Saito
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Corresponding author

Correspondence to Yoshihiro Saito.

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Published in the topical collection celebrating ABCs 13th Anniversary.

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Ueta, I., Mochizuki, S., Kawakubo, S. et al. A novel miniaturized extraction capillary for determining gaseous formaldehyde by high-performance liquid chromatography. Anal Bioanal Chem 407, 899–905 (2015). https://doi.org/10.1007/s00216-014-8144-6

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  • DOI: https://doi.org/10.1007/s00216-014-8144-6

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