As firms increasingly engage in both corporate social responsibility (CSR) and irresponsibility (CSIR) activities, this study expands the traditional question “does it pay to do more CSR?” to explore the less-studied question “does it pay to do less CSIR?”. We employ stakeholder theory and expectancy disconfirmation theory to outline three sustainable strategies for firms to financially benefit (enlightened self-interest) from CSR/CSIR activities: proactive strategy (increasing CSR, or doing more good), rectification strategy (reducing CSIR, or doing less bad), and aggressive strategy (increasing CSR while reducing CSIR, or doing more good and less bad). Our research objective is to evaluate the financial viability of different CSR/CSIR strategies. We hypothesize that the rectification strategy will surpass the proactive approach, while anticipating that the aggressive strategy will emerge as the most financially advantageous. Our dataset consists of 12,567 firm-year observations (3422 firms) spanning 1994 to 2013, and we conduct rigorous analyses to evaluate these strategies. The findings reveal that the rectification strategy surpasses the proactive strategy, with the aggressive strategy emerging as the most advantageous. The study contributes theoretically and offers managerial insights into these results. Full article

Online medical teams (OMTs), a new mode of online healthcare service, have emerged in online health communities (OHCs) in China. This study attempts to explore the underlying mechanism of how OMTs’ engagement influences patient satisfaction through the lens of semantic features. This study also scrutinizes the moderating effect of multiple specializations on the link between OMTs’ engagement and semantic features. We utilized a linear model that had fixed effects controlled at the team level for analysis. A bootstrapping approach using 5000 samples was employed to test the mediation effects. The findings reveal that OMTs’ engagement significantly improves language concreteness in online team consultations, which subsequently enhances patient satisfaction. OMT engagement has a negative impact on emotional intensity, ultimately decreasing patient satisfaction. Multiple specializations strengthen the impact of OMT engagement on both language concreteness and emotional intensity. This study contributes to the literature on OMTs and patient satisfaction, providing insights into patients’ perceptions of OMTs’ engagement during online team consultation. This study also generates several implications for the practice of OHCs and OMTs. Full article

Histones are keys to many epigenetic events and their complexes have therapeutic and diagnostic importance. The determination of the structures of histone complexes is fundamental in the design of new drugs. Computational molecular docking is widely used for the prediction of target–ligand complexes. Large, linear peptides like the tail regions of histones are challenging ligands for docking due to their large conformational flexibility, extensive hydration, and weak interactions with the shallow binding pockets of their reader proteins. Thus, fast docking methods often fail to produce complex structures of such peptide ligands at a level appropriate for drug design. To address this challenge, and improve the structural quality of the docked complexes, post-docking refinement has been applied using various molecular dynamics (MD) approaches. However, a final consensus has not been reached on the desired MD refinement protocol. In this present study, MD refinement strategies were systematically explored on a set of problematic complexes of histone peptide ligands with relatively large errors in their docked geometries. Six protocols were compared that differ in their MD simulation parameters. In all cases, pre-MD hydration of the complex interface regions was applied to avoid the unwanted presence of empty cavities. The best-performing protocol achieved a median of 32% improvement over the docked structures in terms of the change in root mean squared deviations from the experimental references. The influence of structural factors and explicit hydration on the performance of post-docking MD refinements are also discussed to help with their implementation in future methods and applications. Full article

Sheep and goat may become carriers of some zoonotic diseases. They are important livestock and experimental model animals for human beings. The fast and accurate identification of genetic materials originating from sheep and goat can prevent and inhibit the spread of some zoonotic diseases, monitor market product quality, and maintain the stability of animal husbandry and food industries. This study proposed a methodology for identifying sheep and goat common specific sites from a genome-wide perspective. A total of 150 specific sites were selected from three data sources, including the coding sequences of single copy genes from nine species (sheep, goat, cow, pig, dog, horse, human, mouse, and chicken), the dbSNPs for these species, and human 100-way alignment data. These 150 sites exhibited low intraspecific heterogeneity in the resequencing data of 1450 samples from five species (sheep, goat, cow, pig, and chicken) and high interspecific divergence in the human 100-way alignment data after quality control. The results were proven to be reliable at the data level. Using the process proposed in this study, specific sites of other species can be screened, and genome-level species identification can be performed using the screened sites. Full article

A rare consensus points to the question of normativity, with an inclination towards the Eurocentric Frankfurt School of Critical Theory, which seems to have been central to Critical Terrorism Studies (CTS). Given the universality of knowledge exerting pressure on scholars to conform with traditional theoretical perspectives, terrorism studies pose inequality from Eurocentricity emerging in “the battle for hearts and minds” research. Some of these studies fall to the allure of connivance with the progressively “authoritarian demands of Western, liberal state and media practice”. Consequently, terrorism research risks being dominated by ethical and logical blindness within established research formations. In Africa, for example, some CTS scholars are subdued to cynically use their Africanity to authenticate the neo-colonial and neo-liberal agenda in terrorism research. This article explores the reimaging of subjugated knowledge through decolonisation of methods in CTS. Rooting for cognitive justice and adequate space for alternative knowledge to imperial science, the article contests the battle for Africa’s hearts and minds as a failed process that needs transformation. Consequently, this work is a contribution to epistemological debate between the global North and South, and the subsequent theoretical contestations in CTS. We argue for hybridity by re-constructing alternative frameworks of knowledge production. Full article

The International Maritime Organization (IMO) is currently rolling out more restrictive regulations in order to achieve net-zero GHG emissions by 2050. In response, the shipping industry is planning to pivot to green energy sources such as hydrogen fuel. However, since hydrogen has an extremely low boiling point (−253 °C), materials for storing liquid hydrogen must be highly resistant to low-temperature brittleness and hydrogen embrittlement. A 316L stainless steel is a typical material that meets these requirements, and various welds have been studied. In this study, 3 pass butt welding was performed by applying the FCAW (flux cored arc welding) process to 10 mm thick ASTM-A240M-316L stainless steel, with the size of the fusion zone and HAZ investigated by mechanical testing and heat transfer FE analysis according to process variables, such as heat input, welding speed, and the number of passes. In all cases, the yield and tensile strengths were about 10% and 3% higher than the base metal, respectively. Furthermore, heat transfer FE analysis showed an average error rate of 1.3% for penetration and 10.5% for width and confirmed the size of the HAZ, which experienced temperatures between 500 °C and 800 °C. Full article

In this study, we prepared the SnO₂/ZnFe₂O₄ (SZ) composite magnetic photocatalyst via a two-step hydrothermal method. Structural and performance analyses revealed that SZ-5 with a ZnFe₂O₄ mass ratio of 5% (SZ-5) exhibited optimal photocatalytic activity, achieving a 72.6% degradation rate of Rhodamine B (RhB) solution within 120 min. SZ-5 consisted of irregular nano blocks of SnO₂ combined with spherical nanoparticles of ZnFe₂O₄, with a saturated magnetization intensity of 1.27 emu/g. Moreover, the specific surface area of SnO₂ loaded with ZnFe₂O₄ increased, resulting in a decreased forbidden bandwidth and expanded light absorption range. The construction of a Z-type heterojunction structure between SnO₂ and ZnFe₂O₄ facilitated the migration of photogenerated charges, reduced the recombination rate of electron-hole pairs, and enhanced electrical conductivity. During the photocatalytic reaction, RhB was degraded by·OH, O₂⁻, and h⁺, in which O₂⁻ played a major role. Full article

Background: Resection margins are an important prognostic factor for patients with head and neck cancer. In general, for head and neck surgery, a margin > 5 mm is advised by the Royal College of Pathologists. However, this cannot always be achieved during laryngeal and hypopharyngeal surgery. The aim of this study is to identify the resection surfaces and measure the maximum feasible margins per subsite. The clinical relevance of these maximum feasible resection margins were analyzed in this descriptive anatomical study. Methods: head and neck surgeons and a pathologist from the Erasmus MC performed a total laryngectomy and laryngopharyngectomy on a head and neck specimen specifically available for research. Results: For a total laryngectomy, resection margins > 5 mm were not feasible for the ventral and dorsal resection surface. For a total laryngopharyngectomy, resection margins > 5 mm were not feasible for the ventral, dorsal and lateral resection surface. Conclusion: Clear resection margins, defined as a margin > 5 mm, are not always feasible in laryngeal and hypopharyngeal surgery, due to the anatomy of the larynx and tumor location. However, striving for a maximum feasible margin is still the main goal. We propose a new guideline for maximum feasible but adequate resection margins in larynx and hypopharynx tumor surgery. Full article

The influence of elevated temperatures and strain rate on the mechanical and structural properties of steel 42CrMo4 were analysed experimentally in this paper. The experiments were based on uniaxial tension and compression tests at high temperatures between 700 °C and 1100 °C and strain rates in the range 0.0018–0.1 s⁻¹. The influence of temperature and strain rate on yield stress, strain to fracture, hardness, structural changes, and fracture characteristics were analysed. The non-uniformity of deformations obtained at different values of the strain rate and temperature were also analysed. Analysis by scanning electron microscopy showed the ductile behaviour of the material. The degree of damage in the material caused by the presence of cavities increased with increasing deformation temperature. For all the presented deformation conditions, the formation of the fracture through the ductile fracture mechanism resulted from localized necking and the coalescence of microvoids. By increasing the deformation temperature and reducing the strain rate, the fracture behaviour of 42CrMo4 steel can be improved. Full article

The genus Brassica is an important source of food in the Mediterranean diet with documented nutritional and medicinal properties. However, few studies have investigated the phytochemical composition and the biological activity of wild Sicilian taxa. Thus, we aimed to study the chemical profile and the antioxidant potential, in vitro and in LPS-stimulated RAW 264.7 cells, of a methanolic extract of leaves of wild Brassica macrocarpa Guss (B. macrocarpa) (Egadi Islands; Sicily-Italy). B. macrocarpa methanolic extract showed a large amount of glucosinolates and different phenolic compounds. It exhibited antioxidant activity in the DPPH assay and in LPS-stimulated RAW 264.7 cells, being able to reduce NO and ROS levels and NOS2 mRNA expression. Our study demonstrated that Sicilian B. macrocarpa methanolic extract, in LPS-stimulated macrophages, efficiently counteracts oxidative stress and displays radical scavenging activity. Future studies are required to identify the contribution of the single phytocomponents, to characterize the action mechanism, and to reveal possible applications in human health. Full article

Unsupervised domain adaptation (UDA) aims to reapply the classifier to be ever-trained on a labeled source domain to a related unlabeled target domain. Recent progress in this line has evolved with the advance of network architectures from convolutional neural networks (CNNs) to transformers or both hybrids. However, this advance has to pay the cost of high computational overheads or complex training processes. In this paper, we propose an efficient alternative hybrid architecture by marrying transformer to contextual convolution (TransConv) to solve UDA tasks. Different from previous transformer based UDA architectures, TransConv has two special aspects: (1) reviving the multilayer perception (MLP) of transformer encoders with Gaussian channel attention fusion for robustness, and (2) mixing contextual features to highly efficient dynamic convolutions for cross-domain interaction. As a result, TransConv enables to calibrate interdomain feature semantics from the global features and the local ones. Experimental results on five benchmarks show that TransConv attains remarkable results with high efficiency as compared to the existing UDA methods. Full article

Currently, there are many enterprises involved in extracting and processing of primary raw materials. The danger of working in this industry consists in the formation of cracks in rocks of the pit side slopes, which can lead to destruction. This article discusses the existing systems for monitoring the pit collapse prevention. The most promising is the use of systems with fiber-optic sensors. However, use of these systems is associated with some difficulties due to high costs, low noise immunity, and in some cases, the requirement for additional equipment to improve the reliability of measurements. A completely new method of processing the data from a fiber-optic sensor that simplifies the design and reduces the cost of the device is proposed considering the experience of previous developments. The system uses artificial intelligence, which improves the data processing. The theoretical part is dedicated to the development of foundations, and the analysis of the nonlinear properties of the physical and mathematical model of optical processes associated with the propagation of an electromagnetic wave in a fiber-optic material was developed. The results of experimental and theoretical applied research, which are important for the development of fiber-optic systems for monitoring the pit collapse prevention, are presented. The dependences of optical losses and the number of pixels on the dis-placement were obtained. The accuracy of the method corresponds to the accuracy of the device by which it is calibrated and is 0.001 mm. The developed hardware-software complex is able to track the rate of changing the derivative of the light wave intensity in time, as well as changing the shape of the spot and transition of pixels from white to black. Full article

Fluoropyrimidine (FP) drugs are central components of combination chemotherapy regimens for the treatment of colorectal cancer (CRC). FP-based chemotherapy has improved survival outcomes over the last several decades with much of the therapeutic benefit derived from the optimization of dose and delivery. To provide further advances in therapeutic efficacy, next-generation prodrugs and nanodelivery systems for FPs are being developed. This review focuses on recent innovative nanodelivery approaches for FP drugs that display therapeutic promise. We summarize established, clinically useful FP prodrug strategies, including capecitabine, which exploit tumor-specific enzyme expression for optimal anticancer activity. We then describe the use of FP DNA-based polymers (e.g., CF10) for the delivery of activated FP nucleotides as a nanodelivery approach with proven activity in pre-clinical models and with clinical potential. Multiple nanodelivery systems for FP delivery show promise in CRC pre-clinical models and we review advances in albumin-mediated FP delivery, the development of mesoporous silica nanoparticles, emulsion-based nanoparticles, metal nanoparticles, hydrogel-based delivery, and liposomes and lipid nanoparticles that display particular promise for therapeutic development. Nanodelivery of FPs is anticipated to impact CRC treatment in the coming years and to improve survival for cancer patients. Full article

The use of secondary metabolites of rice to control pests has become a research hotspot, but little is known about the mechanism of rice self-resistance. In this study, metabolomics analysis was performed on two groups of rice (T1, with insect pests; T2, without pests), indicating that fatty acids, alkaloids, and phenolic acids were significantly up-regulated in T1. The up-regulated metabolites (p-value < 0.1) were enriched in linoleic acid metabolism, terpene, piperidine, and pyridine alkaloid biosynthesis, α-linolenic acid metabolism, and tryptophan metabolism. Six significantly up-regulated differential metabolites in T1 were screened out: N-trans-feruloyl-3-methoxytyramine (1), N-trans-feruloyltyramine (2), N-trans-p-coumaroyltyramine (3), N-cis-feruloyltyramine (4), N-phenylacetyl-L-glutamine (5), and benzamide (6). The insect growth inhibitory activities of these six different metabolites were determined, and the results show that compound 1 had the highest activity, which significantly inhibited the growth of Chilo suppressalis by 59.63%. Compounds 2–4 also showed a good inhibitory effect on the growth of Chilo suppressalis, while the other compounds had no significant effect. RNA-seq analyses showed that larval exposure to compound 1 up-regulated the genes that were significantly enriched in ribosome biogenesis in eukaryotes, the cell cycle, ribosomes, and other pathways. The down-regulated genes were significantly enriched in metabolic pathways, oxidative phosphorylation, the citrate cycle (TCA cycle), and other pathways. Eighteen up-regulated genes and fifteen down-regulated genes from the above significantly enriched pathways were screened out and verified by real-time quantitative PCR. The activities of detoxification enzymes (glutathione S-transferase (GST); UDP-glucuronosyltransferase (UGT); and carboxylesterase (CarE)) under larval exposure to compound 1 were measured, which indicated that the activity of GST was significantly inhibited by compound 1, while the activities of the UGT and CarE enzymes did not significantly change. As determined by UPLC-MS, the contents of compound 1 in the T1 and T2 groups were 8.55 ng/g and 0.53 ng/g, respectively, which indicated that pest insects significantly induced the synthesis of compound 1. Compound 1 may enhance rice insect resistance by inhibiting the detoxification enzyme activity and metabolism of Chilo suppressalis, as well as promoting cell proliferation to affect its normal growth and development process. The chemical–ecological mechanism of the insect resistance of rice is preliminarily clarified in this paper. Full article

The development of low-cost, high-performance oxygen electrocatalysts is of great significance for energy conversion and storage. As a potential substitute for precious metal electrocatalysts, the construction of efficient and cost-effective oxygen electrocatalysts is conducive to promoting the widespread application of zinc–air batteries. Herein, Co_xNi_yMOF nanoparticles encapsulated within a carbon matrix were synthesized and employed as cathode catalysts in zinc–air batteries. Co_0.5Ni_0.5MOF exhibits superior oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) performance and durability. The zinc–air battery assembled with Co_0.5Ni_0.5MOF as the air cathode exhibits a maximum power density of 138.6 mW·cm⁻². These improvements are mainly attributed to the optimized metal composition of the cobalt–nickel alloy, which increases the specific surface area of the material and optimizes its pore structure. Significantly, the optimization of the electronic structure and active sites within the material has led to amplified ORR/OER activity and better zinc–air battery performance. This study underscores the immense promise of Co_0.5Ni_0.5MOF catalysts as feasible substitutes for commercial Pt/C catalysts in zinc–air batteries. Full article

Safe landings are imperative to accomplish NASA’s Artemis goal to enable human exploration on the Moon, including sample collection missions. However, a process known as plume surface interaction (PSI) presents a significant hazard to lunar landings. PSI occurs when the engine exhaust of a lander interacts with the surface ejecting large amounts of regolith particles at high velocities that can interfere with the landing, disturb the surface, and damage hardware. To better understand PSI, the particle impact event (PIE) sensor is being developed to measure the kinetic energy and the flux of ejecta during landings, to quantify the potential damage, and to quantify the ejecta displaced. Multiple parameters were estimated to define the PIE instrument requirements. These estimates demonstrate that ejecta can travel at velocities of up to 800 m/s and impact the surrounding area with energies of up to 400 µJ. A significant amount of ejecta can be deposited several 10 s of meters away from the landing site, modifying the surface and causing dust-related challenges. The PIE sensor will be launched for the first time in an upcoming lunar lander. Then, PIE measurements will be used to improve PSI prediction capabilities and develop mitigation strategies to ensure safe landings. Full article

This study explored the positive effects of a six-week Social–Emotional and Ethical Learning^® (SEE Learning) program on resilience and social and emotional competences, adapted for elementary students in Daegu, South Korea, a region strongly affected by the first outbreak of COVID-19. A total of 348 third- and fourth-grade students from 15 elementary schools participated, and the curriculum was tailored, emphasizing key areas such as resilience, attention, kindness, attention training, and compassion. Repeated measures analysis of variance (RMANOVA) tests showed statistically significant improvements between pre- and post-tests in resilience and its subscales, including self-efficacy, tolerance of negative affect, positive support relations, power of control, and spontaneity, as well as in social and emotional competencies, including emotional regulation, social skills, empathy, and social tendencies. Despite a lack of maintenance in all areas, at follow-up, the mean scores for self-efficacy, tolerance of negative affect, and positive support relations, as well as emotional regulation, social skills, empathy, and social tendency, remained higher than pre-test levels, suggesting some lasting benefits. The findings underscore the potential of the SEE Learning program integrated with resilience, mindfulness, compassion, and ethical practices to enhance students’ resilience and social and emotional well-being. This study contributes to the growing body of evidence supporting the use of mindfulness and compassion-based SEL programs to mitigate the adverse effects of traumatic events on children’s mental health. Full article

Cattle ticks are a significant health concern in tropical livestock production due to their hematophagous behavior and potential as vectors for human and animal pathogens. In this study, we investigated the tick population present in dairy cattle production, calves, and grazing areas of livestock systems in the northwestern Colombian Amazon. Identification was based on taxonomic keys and molecular markers. Phylogenetic relationships were established using mitochondrial COX1 and 16S genes. Population structure analysis was performed considering age, racial type (B. indicus vs. B. taurus), and the influence of environmental factors and the geomorphological landscape on tick population dynamics. Our findings revealed the presence of a single tick species, with a unique haplotype identified for each mitochondrial gene assessed. Phylogenetic analysis classified the found species within Clade A of the Rhipicephalus microplus complex. Ticks were more prevalent during periods of low rainfall and high temperature, and B. taurus cows exhibited the highest tick abundance. Thus, these results provide insights into the population characteristics and distribution of the tick species present in dairy cattle production systems in the northwestern part of the Colombian Amazon. This information is fundamental for developing targeted strategies based on seasonal variation and host characteristics to mitigate tick infestation severity in the region. Full article

The localization of deformation in shear bands is a fundamental phenomenon in granular materials like soil. In this study, we focus on the characteristics of shear bands, particularly the size effect, by implementing biaxial discrete element method (DEM) modeling. Firstly, we describe the establishment of the biaxial experimental model with dense sands. Then, we implement analyses of specimens with different sizes and find that there is a clear size effect in the stress–strain curve after the peak strength point, and there is less of a size effect in the angle of the shear band; the angle is consistent with Arthur’s theory. Finally, the reason for the size effect is analyzed using the width of the shear band and the porosity inside the shear band. As the specimen size increases, the ratio between the shear band area and the whole specimen decreases. This effect reduces as the isotropic confining stress increases. The difference in the proportion of the shear band area mainly causes the size effect that affects the specimen deformation characteristics. We also find that with the increase in isotropic confining stress, the type of shear band gradually changes from cross-type to single-type. Our study provides valuable insights into understanding the behavior of granular materials. Full article

Data integration is considered a classic research field and a pressing need within the information science community. Ontologies play a critical role in such processes by providing well-consolidated support to link and semantically integrate datasets via interoperability. This paper approaches data integration from an application perspective by looking at ontology matching techniques. As the manual matching of different sources of information becomes unrealistic once the system scales up, the automation of the matching process becomes a compelling need. Therefore, we have conducted experiments on actual non-semantically enriched relational data with the support of existing tools (pre-LLM technology) for automatic ontology matching from the scientific community. Even considering a relatively simple case study—i.e., the spatio–temporal alignment of macro indicators—outcomes clearly show significant uncertainty resulting from errors and inaccuracies along the automated matching process. More concretely, this paper aims to test on real-world data a bottom-up knowledge-building approach, discuss the lessons learned from the experimental results of the case study, and draw conclusions about uncertainty and uncertainty management in an automated ontology matching process. While the most common evaluation metrics clearly demonstrate the unreliability of fully automated matching solutions, properly designed semi-supervised approaches seem to be mature for more generalized application. Full article

Transition metal catalysis has contributed to the discovery of novel methodologies and the preparation of natural products, as well as new chances to increase the chemical space in drug discovery programs. In the case of marine drugs, this strategy has been used to achieve selective, sustainable and efficient transformations, which cannot be obtained otherwise. In this perspective, we aim to showcase how a variety of transition metals have provided fruitful couplings in a wide variety of marine drug-like scaffolds over the past few years, by accelerating the production of these valuable molecules. Full article

This study explores the complexities of urban planning and addresses major issues by carefully weighing four options for smart city technology, community-based development, green infrastructure investment, and transit-oriented development. Unlike traditional evaluations, our study applies the novel SWARA-WASPAS model to spherical fuzzy sets (SFSs), thus identifying and navigating the uncertainty present in decision making. This methodological approach improves the accuracy of our assessment by providing detailed information about the advantages and disadvantages of each option. Our study offers useful insights for urban policymakers and planners using carefully weighted criteria and employing a methodical ranking procedure. The aim is to provide insights for decisions that promote equity, environmental consciousness, resilience, and symmetry in urban environments. The application of the SWARA-WASPAS approach not only advances the field but also provides a strong basis for informed decision making. This improves the accuracy of our evaluations and provides detailed insights into each option’s pros and cons. Our study uses weighted criteria and systematic ranking to advise urban policymakers and planners. Our main goal is to help urban populations make resilient, environmentally responsible, equitable, and symmetrical decisions. Our research aims to further the conversation on sustainable urban development by offering a framework based on data that addresses the difficulties associated with dynamic urban environments. In the end, we want our humanized viewpoint to speak to a wider audience and inspire a shared dedication to creating cities that flourish in the face of changing urban environments. Full article