SFX by Ex Libris Inc.

Title:	A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles
Source:	Cell [0092-8674] Subramanian, Aravind yr:2017

Basic

Sorry, no full text available...

Please use the document delivery service (see below)

Holding information

Holdings in library search engine ALBERT

Document delivery

Request document via Library/Bibliothek

Users interested in this article also expressed an interest in the following:
description	1.	Lamb, J. "The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease." Science 313.5795 (2006): 1929-35.
description	2.	Leshchiner, Elizaveta S. "Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease." Proceedings of the National Academy of Sciences of the United States of America 114.43 (2017): 11392-11397.
description	3.	Tobe, Brian T D D. "Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis." Proceedings of the National Academy of Sciences of the United States of America 114.22 (2017).
description	4.	Carroll, Jeffrey B. "Potent and Selective Antisense Oligonucleotides Targeting Single-Nucleotide Polymorphisms in the Huntington Disease Gene / Allele-Specific Silencing of Mutant Huntingtin." Molecular therapy 19.12 (2011): 2178-2185.
description	5.	Lamb, J. "The Connectivity Map: a new tool for biomedical research." Nature reviews. Cancer 7.1 (2006): 54-60.
description	6.	Michnick, Stephen W. "The connectivity map." Nature Chemical Biology 2.12 (2006): 663-4.
description	7.	Wei, G. "Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance." Cancer cell 10.4 (2006): 331-42.
description	8.	Hieronymus, H. "Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators." Cancer cell 10.4 (2006): 321-30.
description	9.	Tabrizi, Sarah J. "Huntington's Disease: Clinical Presentation and Treatment." Int Rev Neurobiol 98 (2011): 297-323.
description	10.	Bennett, C. "RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform." Annual Review of Pharmacology and Toxicology 50.1 (2010): 259-293.
description	11.	Lu, J. "MicroRNA expression profiles classify human cancers." Nature 435.7043 (2005): 834-838.
description	12.	Murano, T. "Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo." Scientific Reports 7.1 (2017): 13938-13938.
description	13.	Vegh, Z. "Editorial: co-existing immune-mediated disease in inflammatory bowel diseases - a new disease severity indicator?" Alimentary pharmacology & therapeutics 45.8 (2017): 1167-1167.
description	14.	Iaconelli, J. "Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells." ACS chemical biology. 12.8: 2139-2148.
description	15.	Baumholtz, Amanda I. "Claudins are essential for cell shape changes and convergent extension movements during neural tube closure." Developmental biology 428.1 (2017): 25-38.
description	16.	MIURA, T. "Comparative efficacy and tolerability of pharmacological treatments in the maintenance treatment of bipolar disorder: a systematic review and network meta-analysis." The Lancet Psychiatry 1.5 (2014): 351-359.
description	17.	Zuccato, C. "Molecular mechanisms and potential therapeutical targets in Huntington's disease." Physiological reviews 90.3 (2010): 905-981.
description	18.	Warby, C. "CAG Expansion in the Huntington Disease Gene Is Associated with a Specific and Targetable Predisposing Haplogroup." American journal of human genetics 84.3 (2009): 351-366.
description	19.	DiFiglia, M. "Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits." Proceedings of the National Academy of Sciences of the United States of America 104.43 (2007): 17204-9.
description	20.	Friend, S. "Accelerating drug discovery: Open source cancer cell biology?" Cancer cell 10.5 (2006): 349-351.