The 2023 MDPI Annual Report has
been released!
 
20 pages, 22104 KiB  
Article
The (Building) Stones of Venice under Threat: A Study about Their Deterioration between Climate Change and Land Subsidence
by Gloria Zaccariello, Elena Tesser, Rebecca Piovesan and Fabrizio Antonelli
Sustainability 2024, 16(11), 4701; https://doi.org/10.3390/su16114701 (registering DOI) - 31 May 2024
Abstract
Cultural heritage assets face significant threats from climate change and land subsidence, leading to extensive social, economic, and environmental losses, and damage to artistic and monumental heritage in Italian coastal cities. In particular, addressing these challenges in the Venetian context necessitates the development [...] Read more.
Cultural heritage assets face significant threats from climate change and land subsidence, leading to extensive social, economic, and environmental losses, and damage to artistic and monumental heritage in Italian coastal cities. In particular, addressing these challenges in the Venetian context necessitates the development of an adaptation plan for the lagoon area and the identification of targeted intervention strategies to preserve cultural and territorial heritage. To address these objectives, a systematic study was conducted to investigate the deterioration patterns exhibited by the most representative lithologies used in Venetian buildings. Thirty samples of five carbonate stone varieties subjected to natural aging were monitored in six different areas of Venice’s historic center and on Torcello Island, selected based on altimetry relative to tidal zero and exposure to environmental forces. An integrated multi-analytical approach was employed to identify and map macro- and micro-morphologies of stone surfaces related to chemical weathering and physical decay. Stones underwent evaluation during nine monitoring periods using various tests (ultrasound P-wave velocity and colorimetric measures) and analyses (µX-Ray Fluorescence, X-ray powder diffraction, stereomicroscope observations, and recognition of biological patinas). Data processing aimed to elucidate how microclimate and intrinsic stone features influence the occurrence and progression of deterioration phenomena. From the experimental findings, a Stone Deterioration Index and Intervention Procedures (SDIi) were proposed to estimate deterioration rates and assess the need for targeted intervention through conservative actions. Full article
(This article belongs to the Section Tourism, Culture, and Heritage)
Show Figures

Figure 1

15 pages, 863 KiB  
Article
Surgical Treatment of Neovascular Glaucoma Secondary to Proliferative Diabetic Retinopathy in Japanese Patients without the Use of Glaucoma Drainage Devices
by Masaru Takeuchi, Takayuki Kanda, Kozo Harimoto, Daisuke Sora, Rina Okazawa and Tomohito Sato
J. Clin. Med. 2024, 13(11), 3252; https://doi.org/10.3390/jcm13113252 (registering DOI) - 31 May 2024
Abstract
Purpose: The purpose of this study is to investigate outcomes of visual acuity (VA) and intraocular pressure (IOP) in proliferative diabetic retinopathy (PDR)-associated neovascular glaucoma (NVG) in Japanese patients treated with surgical therapies without the use of glaucoma drainage devices. Methods: A retrospective [...] Read more.
Purpose: The purpose of this study is to investigate outcomes of visual acuity (VA) and intraocular pressure (IOP) in proliferative diabetic retinopathy (PDR)-associated neovascular glaucoma (NVG) in Japanese patients treated with surgical therapies without the use of glaucoma drainage devices. Methods: A retrospective analysis of medical records was conducted for 31 consecutive PDR-associated NVG patients who underwent surgical treatments in our institution between 2013 and 2022. Patient demographics, clinical characteristics, VA, and IOP were recorded at the first and last visits, and surgical procedures, including pars plana vitrectomy with extensive panretinal and ciliary photocoagulation (PPV–PRCP), diode laser trans-scleral cyclophotocoagulation (DCPC), and trabeculectomy with mitomycin C (TLE–MMC), with or without a prior intravitreal bevacizumab (IVB) injection, were reviewed. Results: Of the thirty-one PDR patients with NVG, two patients received PPV–PRCP or DCPC alone (6.5%), respectively, three patients received TLE–MMC alone (9.7%), two patients received TLE–MMC after IVB (6.5%), six patients received PPV–PRCP and TLE–MMC (19.4%), seven patients received PPV–PRCP and TLE–MMC after IVB (22.6%), five patients received PPV–PRCP and DCPC and TLE–MMC (16.1%), and four patients received PPV–PRCP and DCPC and TLE–MMC after IVB (12.9%). The VA of two patients (6.5%) deteriorated to no light perception. In all patients, the mean logMAR VA was 1.28 ± 1.05 at the first visit and remained at 1.26 ± 1.08 at the last visit, with no significant change; the mean IOP was 33.0 ± 15.2 mmHg at the initial visit and decreased significantly to 14.0 ± 7.4 mmHg at the last visit. The number of eyes with IOP ≥ 21 decreased from twenty-eight (90.3%) to three (9.7%). Although IOP in patients with IOP > 30 mmHg at the initial visit reduced to a level comparable to that of patients with IOP ≤ 30 mmHg, the IOP > 30 mmHg group received IVB more frequently and had significantly higher logMAR VA at the last visit compared to the IOP ≤ 30 mmHg group. Hypotony (<6 mmHg) was observed in four eyes (12.9%). Conclusions: In PDR patients with NVG, various combinations of PPV–PRCP, DCPC, and TLE–MMC after adjunctive IVB without the use of glaucoma drainage devices lowered IOP sufficiently; for these patients, neovascular regression was observed, with no further deterioration of VA. However, surgical procedures should be performed for PDR patients with NVG before visual impairment occurs. On the other hand, approximately less than 15% of patients developed blindness or low IOP. Full article
Show Figures

Figure 1

13 pages, 316 KiB  
Review
Mediterranean Dietary Pattern for Healthy and Active Aging: A Narrative Review of An Integrative and Sustainable Approach
by Polina Dobroslavska, Maria Leonor Silva, Filipa Vicente and Paula Pereira
Nutrients 2024, 16(11), 1725; https://doi.org/10.3390/nu16111725 (registering DOI) - 31 May 2024
Abstract
The global population is on a trajectory of continuous growth, with estimates projecting an increase from 7.7 billion in 2019 to approximately 9.7 billion by 2050. Longevity is also expected to rise rapidly, with advancements in healthcare contributing to increased life expectancies and [...] Read more.
The global population is on a trajectory of continuous growth, with estimates projecting an increase from 7.7 billion in 2019 to approximately 9.7 billion by 2050. Longevity is also expected to rise rapidly, with advancements in healthcare contributing to increased life expectancies and an increase in the maximum lifespan. The aging process is accompanied by different changes, often leading to a decline in daily life activities and an increased susceptibility to disease. Age-related changes can cause cellular damage and subsequent cellular death. Oxidative stress and inflammation play significant roles in this process contributing to molecular damage and mitochondrial dysfunction. Active aging has been associated with improved quality of life and a reduced risk of morbidity and premature mortality. In this context, the Mediterranean diet has emerged as a promising approach to promoting healthy aging and sustainability. The phytochemical compounds within the Mediterranean diet have been linked to a lower risk of developing cardiovascular disease, type 2 diabetes, obesity, cancer and neurodegenerative diseases. The findings of peer-reviewed articles regarding the use of the Mediterranean diet as a healthy and sustainable dietary pattern written in Portuguese, Spanish or English were included in this narrative literature review. This dietary pattern’s emphasis on the consumption of fresh and local food aligns with both health and environmental sustainability goals. This work provides a comprehensive review of the benefits of the Mediterranean diet and its components in a healthy aging process and highlights the importance of this dietary pattern as a sustainable approach. Full article
23 pages, 1425 KiB  
Article
Analysis of an Evaporative Cooling Pad Connected to an Air Distribution System of Perforated Polyethylene Tubes in a Greenhouse
by Sofía Pardo-Pina, Javier Ferrández-Pastor, Francisco Rodríguez and José M. Cámara-Zapata
Agronomy 2024, 14(6), 1187; https://doi.org/10.3390/agronomy14061187 (registering DOI) - 31 May 2024
Abstract
The increase in ambient temperature decreases crop yields. Therefore, greenhouse cooling techniques can be considered adaptation strategies to climate change. To improve the efficiency of crop production, semi-closed greenhouses are utilized, which reduce the mass and energy transfer from the greenhouse. Frequently, these [...] Read more.
The increase in ambient temperature decreases crop yields. Therefore, greenhouse cooling techniques can be considered adaptation strategies to climate change. To improve the efficiency of crop production, semi-closed greenhouses are utilized, which reduce the mass and energy transfer from the greenhouse. Frequently, these types of structures include an evaporative panel and a distribution system through perforated inflated ducts. To further improve the management of this type of installation, the present work models its behavior. The proper functioning of these installations greatly depends on temperature, as well as the relative humidity of the exterior air. The results show how the exterior climate conditions affect the values of temperature and relative humidity inside the greenhouse due to its effect on the value of evaporative cooling. The cooling capacity of the air per unit mass of evaporated water is reduced when the temperature and/or humidity of the air to be treated in the evaporative panel increases. Thus, when the exterior air is at 40 °C and its relative humidity is 75%, its temperature after passing through the evaporative panel is 15 °C higher than when the initial state of the exterior air is 30 °C and 30%. The effect of the use of frequency drivers in the fans on energy consumption has also been evaluated. A reduction of 8% in the frequency value causes a 22% decrease in the power consumed and a 15% pressure drop in the circuit. Therefore, reducing the frequency of electrical energy can contribute to energy savings without affecting the climate inside the greenhouse. Full article
28 pages, 5175 KiB  
Article
Improved Thermal Management of Li-Ion Batteries with Phase-Change Materials and Metal Fins
by Pierluca Paciolla and Davide Papurello
Batteries 2024, 10(6), 190; https://doi.org/10.3390/batteries10060190 (registering DOI) - 31 May 2024
Abstract
The continuing increase in pollutant emissions requires the use of alternative power sources. This includes the use of electric or hybrid vehicles whose energy storage system is based on batteries of various types, including lithium-ion batteries. The optimum operating temperature is between 15 [...] Read more.
The continuing increase in pollutant emissions requires the use of alternative power sources. This includes the use of electric or hybrid vehicles whose energy storage system is based on batteries of various types, including lithium-ion batteries. The optimum operating temperature is between 15 °C and 35 °C. Too high temperatures can lead to catastrophic phenomena such as thermal runaway. The thermal gradient within the system should not exceed 5 °C. An effective Battery Thermal Management System can mitigate this problem. This study analysed a lithium-ion battery with a bag structure. Temperature control was evaluated using a passive (low-cost) system with phase-change materials (PCMs). The material chosen was n-octadecane (paraffin) due to its thermophysical properties and market price. Four different cooling methods were analysed, including air, fins, pure PCM, and a mixed system of single cells and small battery packs. The results show that an undesirable temperature peak around 50 °C (323.15 K) can occur at hot spots. The best system for containing the temperature inside the battery pack is the PCM cooling system with fins. The optimum fin thickness is 1.5 mm. To contain the temperature inside the battery pack, the number of fins studied is 10, while the best temperature containment is achieved with n+ 1 plates, where n is the number of cells. Full article
25 pages, 2504 KiB  
Article
On the Crush Behavior and Energy Absorption of Sustainable Beverage Cans and Their Polyurethane Foam-Filled Structures: An Experimental Study
by Zelin Wang, Zheng Liu, Yangzuo Liu, Wuning Ma, Zhendong Zhang, Changfang Zhao and Chunhao Yang
Materials 2024, 17(11), 2655; https://doi.org/10.3390/ma17112655 (registering DOI) - 31 May 2024
Abstract
In the pursuit of global energy conservation and emissions reductions, utilizing beverage cans as energy-absorbing components offers potential for a sustainable economy. This study examines the impact of foam filling on the crushing behaviors and energy absorption of various types of beverage cans. [...] Read more.
In the pursuit of global energy conservation and emissions reductions, utilizing beverage cans as energy-absorbing components offers potential for a sustainable economy. This study examines the impact of foam filling on the crushing behaviors and energy absorption of various types of beverage cans. Quasi-static compression tests were conducted on five geometrically sized cans filled with three densities of polyurethane foam to study their deformation modes and calculate crashworthiness parameters within the effective stroke. Results show that empty beverage cans have lower energy absorption capacities, and deformation modes become less consistent as can size increases. Higher foam density leads to increased total energy absorption, a slight reduction in the effective compression stroke, and a tendency for specific energy absorption to initially increase and then decrease. Regarding crush behavior, smaller cans transition from a diamond mode to a concertina mode, while larger cans exhibit a columnar bending mode. Next, the coupling effect of energy absorption between foam and cans was analyzed so as to reveal the design method of energy-absorbing components. The specific energy absorption of smaller cans filled with polyurethane foam is superior to that of similar empty cans. These findings provide valuable insights for selecting next-generation sustainable energy absorption structures. Full article
(This article belongs to the Section Mechanics of Materials)
17 pages, 5152 KiB  
Article
Co-Infection of Tobacco Rattle and Cycas Necrotic Stunt Viruses in Paeonia lactiflora: Detection Strategies, Potential Origins of Infection, and Implications for Paeonia Germplasm Conservation
by Nastassia B. Vlasava, David C. Michener, Siarhei Kharytonchyk and Liliana Cortés-Ortiz
Viruses 2024, 16(6), 893; https://doi.org/10.3390/v16060893 (registering DOI) - 31 May 2024
Abstract
Increasing reports of tobacco rattle virus (TRV) and cycas necrotic stunt virus (CNSV) in herbaceous Paeonia worldwide highlight the importance of conserving the genetic resources of this economically important ornamental and medicinal crop. The unknown origin(s) of infection, differential susceptibility of peony cultivars [...] Read more.
Increasing reports of tobacco rattle virus (TRV) and cycas necrotic stunt virus (CNSV) in herbaceous Paeonia worldwide highlight the importance of conserving the genetic resources of this economically important ornamental and medicinal crop. The unknown origin(s) of infection, differential susceptibility of peony cultivars to these viruses, and elusive disease phenotypes for CNSV in peonies make early detection and management challenging. Here, we report the presence of TRV and CNSV in plants of the University of Michigan living peony collection in the United States and a molecular characterization of their strains. Using sequences of the TRV 194 K RNA polymerase gene, we confirmed TRV infections in seven symptomatic plants (1.07% of all plants in the collection). Using newly developed primers, we recovered sequences of the CNSV RdRp gene and the polyprotein 1 gene region from nine out of twelve samples analyzed, including three from symptomless plants. Four of the nine plants had TRV and CNSV co-infections and showed more severe disease symptoms than plants only infected with TRV. Phylogenetic analyses of isolates from the University of Michigan living peony collection and publicly available isolates point to multiple origins of TRV and CNSV infections in this collection. This is the first report of TRV/CNSV co-infection and of a symptomatic detection of CNSV on cultivated P. lactiflora. Full article
Show Figures

Figure 1

13 pages, 1467 KiB  
Article
Active Electromagnetic Clutch for Crankshaft Decoupling from a Belt Drive System
by Luis M. Castellanos Molina, Renato Galluzzi, Shailesh Hegde, Angelo Bonfitto, Nicola Amati, Andrea Tonoli and Walter Ventura
Appl. Sci. 2024, 14(11), 4770; https://doi.org/10.3390/app14114770 (registering DOI) - 31 May 2024
Abstract
This work presents a novel electromagnetic clutch installed on the crankshaft pulley to decouple the internal combustion engine from the front-end accessory drive of a P0 hybrid electric vehicle. The objective is to supply the air conditioning compressor directly with the belt starter–generator [...] Read more.
This work presents a novel electromagnetic clutch installed on the crankshaft pulley to decouple the internal combustion engine from the front-end accessory drive of a P0 hybrid electric vehicle. The objective is to supply the air conditioning compressor directly with the belt starter–generator electric machine without dragging the inertia of the engine during engine fuel cut-off phases. This operation yields an improved vehicle energetic efficiency and allows for uninterrupted air conditioning also when the start–stop function is activated. This paper focuses on the mechanical assembly and electromagnetic behavior of the device. Furthermore, two position-sensorless techniques are proposed to estimate the clutch state. The effectiveness of the proposed solution is experimentally validated on a dedicated test bench. Experimental tests demonstrated that the opening and closing phases required 50 and 25ms, respectively, thereby satisfying the time constraints for switching different operating modes in a vehicle (∼100ms). Full article
24 pages, 4353 KiB  
Article
Self-Reliance in Community-Based Rural Tourism: Observing Tourism Villages (Desa Wisata) in Sleman Regency, Indonesia
by Yoan A. W. Sutomo, Corinthias P. M. Sianipar, Satoshi Hoshino and Kenichiro Onitsuka
Tour. Hosp. 2024, 5(2), 448-471; https://doi.org/10.3390/tourhosp5020028 (registering DOI) - 31 May 2024
Abstract
Self-reliance is essential for community-based rural tourism (CBRT), ensuring effective running in the long term. However, existing studies have focused on general self-reliance conditions while overlooking details surrounding the community’s self-reliance in each activity of the CBRT value chain. This study filled this [...] Read more.
Self-reliance is essential for community-based rural tourism (CBRT), ensuring effective running in the long term. However, existing studies have focused on general self-reliance conditions while overlooking details surrounding the community’s self-reliance in each activity of the CBRT value chain. This study filled this significant gap by observing community self-reliance in CBRT and considering the tourism value chain (TVC) framework. Built upon the abduction method, this study applied the systematic combining approach to observe three aspects of self-reliance, i.e., goals or objectives, rights and abilities, and owned resources, in the TVC of CBRT entities. Taking the case of CBRT in Sleman Regency, Indonesia, the data collection involved representatives of 49 community-based tourism villages (desa wisata). The results showed that observing community self-reliance in CBRT allows for the identification of multifaceted self-reliance problems in rural tourism communities. Apparently, the observed CBRT initiatives are unable to achieve complete self-sufficiency across all aspects of self-reliance. Reliance on external collaboration and support networks persists out of necessity rather than an inability to self-manage. Policy protections, capacity building, and collaborative partnerships are necessary to develop resilient and sustainable rural tourism amidst necessary dependencies. CBRT planning and policies should hence consider the abovementioned aspects of self-reliance to empower CBRT toward sustainable rural development. Full article
Show Figures

Figure 1

20 pages, 7543 KiB  
Article
Analytical Modeling of Eddy Current Losses and Thermal Analysis of Non-Uniform-Air-Gap Combined-Pole Permanent Magnet Motors for Electric Vehicles
by Shilun Ma, Jianwei Ma, Keqi Chen and Changwei Li
Machines 2024, 12(6), 377; https://doi.org/10.3390/machines12060377 (registering DOI) - 31 May 2024
Abstract
In order to solve the problem of large eddy current losses and high temperature rises caused by a large number of permanent magnets, a new type of combined-magnetic-pole permanent magnet motor is proposed in this paper. The sinusoidally distributed subdomain model of a [...] Read more.
In order to solve the problem of large eddy current losses and high temperature rises caused by a large number of permanent magnets, a new type of combined-magnetic-pole permanent magnet motor is proposed in this paper. The sinusoidally distributed subdomain model of a non-uniform-air-gap rotor was established using the Laplace equation, and the analytical expression of eddy current losses in the rotor in a uniform air gap and non-uniform air gap was derived. The effect of the rotor’s eccentricity on eddy current losses was obtained. According to the characteristics of the distributed winding of the non-uniform-air-gap combined-pole permanent magnet motor, an equivalent treatment was performed to obtain the equivalent thermal conductivity value; to establish an equivalent thermal network model of the motor; determine the temperature of each component of the motor; and verify the correctness of the thermal network model through magnetothermal bidirectional coupling. Finally, an experimental platform was set up to carry out temperature rise experiments on the two prototypes. The experimental results show that a non-uniform-air-gap rotor structure can effectively reduce a rotor’s eddy current losses and motor temperature rise, as well as verify the accuracy of the analytical model’s calculation results. Full article
(This article belongs to the Section Vehicle Engineering)
Show Figures

Figure 1

19 pages, 1186 KiB  
Article
Research on the Impact of Digital Inclusive Finance on Green Innovation of SMEs
by Chunli Du, Min Hu, Tao Wang and Mirakhimova Dilafruz Dilmurod Kizi
Sustainability 2024, 16(11), 4700; https://doi.org/10.3390/su16114700 (registering DOI) - 31 May 2024
Abstract
Green innovation is an effective driving force for high-quality development in the new era. As a new financial service model, digital inclusive finance provides a new way to solve the financing dilemma of green innovation. In order to investigate the impact of digital [...] Read more.
Green innovation is an effective driving force for high-quality development in the new era. As a new financial service model, digital inclusive finance provides a new way to solve the financing dilemma of green innovation. In order to investigate the impact of digital financial inclusion on the green innovation of small and medium-sized enterprises (SMEs), based on the panel data of SMEs in China from 2011 to 2021, this paper empirically tested the influence and mechanism of the two by using the panel fixed effect model and threshold regression model. The findings demonstrate that digital inclusive finance is effective in promoting the green innovation of SMEs and alleviates their financing constraints. The digitization level of digital inclusive finance also has a significant positive and non-linear effect of increasing “marginal effect” on the green innovation of SMEs. Notably, it has a greater significant role in driving green innovation for non-state-owned enterprises, enterprises located in the central and western regions, and SMEs with dispersed equity. Consequently, several policy implications are derived from these findings, which can provide a sustained impetus to help SMEs carry out green innovation activities and also provide a scientific basis for governments to improve digital financial inclusion policies and achieve economic equity. Full article
Show Figures

Figure 1

9 pages, 1667 KiB  
Article
Exploring the Epidemiological Surveillance of Hepatitis A in South Africa: A 2023 Perspective
by Keveshan Bhagwandin, Jayendrie Thaver-Kleitman, Kathleen Subramoney, Morubula Jack Manamela and Nishi Prabdial-Sing
Viruses 2024, 16(6), 894; https://doi.org/10.3390/v16060894 (registering DOI) - 31 May 2024
Abstract
Hepatitis A (HAV) presents a significant global health concern with diverse clinical manifestations primarily transmitted through fecal–oral routes, emphasizing the critical role of sanitation and water cleanliness in transmission dynamics. Age-related variations, notably asymptomatic presentation in children, add complexity. The World Health Organization’s [...] Read more.
Hepatitis A (HAV) presents a significant global health concern with diverse clinical manifestations primarily transmitted through fecal–oral routes, emphasizing the critical role of sanitation and water cleanliness in transmission dynamics. Age-related variations, notably asymptomatic presentation in children, add complexity. The World Health Organization’s (WHO) endemicity classification aids in understanding prevalence and control strategies. This study examines 2023 South African epidemiological data on HAV cases, evaluating age distribution, incidence rates, and provincial disparities. Data from the national surveillance system and weather services were analyzed. Findings reveal distinct age-related trends, with the highest seroprevalence observed in the 5–9 age group with the most burdened areas located in the Western Cape, KwaZulu-Natal, and Gauteng provinces. Furthermore, seasonal rainfall variations correlate with increased incidence in Western Cape and KZN. The amalgamation of results suggest a potential epidemiological shift, emphasizing the need for updated immunization strategies. Noteworthy patterns, like the rise in 5–9-year-olds, may be influenced by factors such as school clustering and migration. Provincial disparities and the impact of climatic events underscore the necessity for dynamic vaccination strategies and surveillance network enhancements. This study highlights the urgency for improved understanding and response to HAV in South Africa. Full article
Show Figures

Figure 1

30 pages, 1499 KiB  
Review
Crosstalk between Inflammation and Atherosclerosis in Rheumatoid Arthritis and Systemic Lupus Erythematosus: Is There a Common Basis?
by Marta Chiara Sircana, Gian Luca Erre, Floriana Castagna and Roberto Manetti
Life 2024, 14(6), 716; https://doi.org/10.3390/life14060716 (registering DOI) - 31 May 2024
Abstract
Cardiovascular disease is the leading cause of morbidity and mortality in patients with rheumatoid arthritis and systemic lupus erythematosus. Traditional cardiovascular risk factors, although present in lupus and rheumatoid arthritis, do not explain such a high burden of early cardiovascular disease in the [...] Read more.
Cardiovascular disease is the leading cause of morbidity and mortality in patients with rheumatoid arthritis and systemic lupus erythematosus. Traditional cardiovascular risk factors, although present in lupus and rheumatoid arthritis, do not explain such a high burden of early cardiovascular disease in the context of these systemic connective tissue diseases. Over the past few years, our understanding of the pathophysiology of atherosclerosis has changed from it being a lipid-centric to an inflammation-centric process. In this review, we examine the pathogenesis of atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis, the two most common systemic connective tissue diseases, and consider them as emblematic models of the effect of chronic inflammation on the human body. We explore the roles of the inflammasome, cells of the innate and acquired immune system, neutrophils, macrophages, lymphocytes, chemokines and soluble pro-inflammatory cytokines in rheumatoid arthritis and systemic lupus erythematosus, and the roles of certain autoantigens and autoantibodies, such as oxidized low-density lipoprotein and beta2-glycoprotein, which may play a pathogenetic role in atherosclerosis progression. Full article
(This article belongs to the Special Issue Clinical Manifestations and Treatment of Autoimmune Diseases)
Show Figures

Figure 1

19 pages, 337 KiB  
Article
Even and Odd Cat States of Two and Three Qubits in the Probability Representation of Quantum Mechanics
by Matyas Mechler, Margarita A. Man’ko, Vladimir I. Man’ko and Peter Adam
Entropy 2024, 26(6), 485; https://doi.org/10.3390/e26060485 (registering DOI) - 31 May 2024
Abstract
We derive the probability representation of even and odd cat states of two and three qubits. These states are even and odd superpositions of spin-1/2 eigenstates corresponding to two opposite directions along the z axis. The probability representation of even and odd cat [...] Read more.
We derive the probability representation of even and odd cat states of two and three qubits. These states are even and odd superpositions of spin-1/2 eigenstates corresponding to two opposite directions along the z axis. The probability representation of even and odd cat states of an oscillating spin-1/2 particle is also discussed. The exact formulas for entangled probability distributions describing density matrices of all these states are obtained. Full article
(This article belongs to the Section Quantum Information)
15 pages, 2015 KiB  
Article
The Cardiovascular Risk Awareness and Health Lifestyle of Italian Women
by Adele Lillo, Ettore Antoncecchi, Valeria Antoncecchi, Giovanni Battista Zito and on behalf of the A.R.C.A. CARIN WOMEN Survey Investigators
J. Clin. Med. 2024, 13(11), 3253; https://doi.org/10.3390/jcm13113253 (registering DOI) - 31 May 2024
Abstract
Background: Cardiovascular (CV) disease is the leading cause of death in women, but few of them are aware of the CV risks (CVRs). Most women are not aware of all the CV risk factorsand their knowledge often still does not improve their lifestyle. [...] Read more.
Background: Cardiovascular (CV) disease is the leading cause of death in women, but few of them are aware of the CV risks (CVRs). Most women are not aware of all the CV risk factorsand their knowledge often still does not improve their lifestyle. Methods: The Carin Women is a survey conducted among Italian women by filling out a questionnaire in the waiting rooms of clinics. The aim was to determine the level of awareness of women’s cardiovascular risk, knowledge of risk factors, and lifestyle. A total of 5590 questionnaires were completed in two different periods. Results: Median age was 56 (IQR 46–65); BMI was 25 (IQR 22–29). Schooling, marital status, and rate of risk conditions were assessed; 311 women (5.57%) had already suffered a cardiovascular event. The relationship between the CV events and the number of traditional risk factors was significant. A similar curve, but without significant differences, was reported for non-traditional risk factors. From the total number of women, 23% with a high CVR and 62% with a very high CVR underestimated thei risk regardless of their level of education. Up to 43% of women underestimated female CV risk compared to male risk. Women showed a good knowledge of traditional risk factors, but only a few of them had a healthy lifestyle: 21.86% were smokers, only 45.88% performed sufficient physical activity, 27.55% did not recognize they were overweight, and only 30.4% consumed more than two daily portions of fruit and vegetables. Most women (86%) need more information about CVR. Conclusions: Italian women underestimate female CVRs and their own CVR. Full article
(This article belongs to the Section Cardiology)
Show Figures

Figure 1

16 pages, 7957 KiB  
Article
Efficient Alcoholysis of Poly(ethylene terephthalate) by Using Supercritical Carbon Dioxide as a Green Solvent
by Yiwei Xu, Ran Cui, Yuqing Han, Jie Jiang, Dongdong Hu, Ling Zhao and Zhenhao Xi
Polymers 2024, 16(11), 1564; https://doi.org/10.3390/polym16111564 (registering DOI) - 31 May 2024
Abstract
In order to reduce the environmental impact of poly(ethylene terephthalate) (PET) plastic waste, supercritical fluids were used to facilitate effective recovery via improved solvent effects. This work focuses on the mechanisms of supercritical CO2 (ScCO2) during the alcoholysis processing of [...] Read more.
In order to reduce the environmental impact of poly(ethylene terephthalate) (PET) plastic waste, supercritical fluids were used to facilitate effective recovery via improved solvent effects. This work focuses on the mechanisms of supercritical CO2 (ScCO2) during the alcoholysis processing of PET using systematic experiments and molecular dynamics (MD) simulations. The results of the alcoholysis experiment indicated that PET chips can be completely depolymerized within only an hour at 473 K assisted with ScCO2 at an optimal molar ratio of CO2/ethanol of 0.2. Random scission of PET dominates the early stage of the depolymerization reaction process, while specific scission dominates the following stage. Correspondingly, molecular dynamics (MD) simulations revealed that the solubilization and self-diffusion properties of ScCO2 facilitate the transportation of alcohol molecules into the bulk phase of PET, which leads to an accelerated diffusion of both oligomers and small molecules in the system. However, the presence of excessive CO2 has a negative impact on depolymerization by weakening the hydrogen bonding between polyester chain segments and ethanol, as well as decreasing the swelling degree of PET. These data provide a deep understanding of PET degradation by alcohols and the enhancement of ScCO2. It should be expected to achieve an efficient and high-yield depolymerization process of wasted polyesters assisted with ScCO2 at a relatively low temperature. Full article
(This article belongs to the Special Issue Degradation and Stabilization of Polymer Materials 2nd Edition)
Show Figures

Figure 1

12 pages, 264 KiB  
Article
Effects of Different Essential Oil Blends and Fumaric Acid on In Vitro Fermentation, Greenhouse Gases, Nutrient Degradability, and Total and Molar Proportions of Volatile Fatty Acid Production in a Total Mixed Ration for Dairy Cattle
by Kelechi A. Ike, Oludotun O. Adelusi, Joel O. Alabi, Lydia K. Olagunju, Michael Wuaku, Chika C. Anotaenwere, Deborah O. Okedoyin, DeAndrea Gray, Peter A. Dele, Kiran Subedi, Ahmed E. Kholif and Uchenna Y. Anele
Agriculture 2024, 14(6), 876; https://doi.org/10.3390/agriculture14060876 (registering DOI) - 31 May 2024
Abstract
The present study evaluated the inclusion of fumaric acid and essential oil blends (EOBs) containing anise, cedarwood, clove, cumin, eucalyptus, garlic, ginger, lavender, lemongrass, nutmeg, oregano, and peppermint at different proportions on in vitro dry matter (DM) disappearance (DMD), fiber fraction disappearance, the [...] Read more.
The present study evaluated the inclusion of fumaric acid and essential oil blends (EOBs) containing anise, cedarwood, clove, cumin, eucalyptus, garlic, ginger, lavender, lemongrass, nutmeg, oregano, and peppermint at different proportions on in vitro dry matter (DM) disappearance (DMD), fiber fraction disappearance, the efficiency of microbial production, and the total volatile fatty acids (VFAs). Ten treatments without (control treatment) or with different EOB/fumaric combinations were used in the study with eight replicates. The EOB inclusion level was 200 μL/g of feed (total mixed ration, (TMR)) while fumaric acid was administered at 3% of the TMR (DM basis). The highest DMD, in vitro true degradable DM, partitioning factor (PF24), and in vitro apparent degradable DM were recorded for the fumaric only treatment and the control. Neutral detergent fiber disappearance was reduced with the inclusion of EOB/fumaric combinations. The production of microbial mass and undegraded DM were higher (p < 0.001) for all EOBs and EOB and fumaric treatments. The inclusion of EOB and fumaric combinations reduced (p < 0.001) the total gas production, methane, and ammonia, with a higher PF24 value noted for EOB3 treatment. The inclusion of individual EOB1 containing garlic, lemongrass, cumin, lavender, and nutmeg in a ratio of 4:2:2:1:1 or combined with fumaric acid yielded the highest propionate concentration across all treatments. We concluded that EOBs decreased methane production and nutrient degradability with better results with the individual EOB1 or EOB1/fumaric combination, which showed a potential enhancement in energy production. Full article
(This article belongs to the Section Farm Animal Production)
19 pages, 2954 KiB  
Protocol
Optimizing Recombinant Cas9 Expression: Insights from E. coli BL21(DE3) Strains for Enhanced Protein Purification and Genome Editing
by Shilpi Agrawal, Made Harumi Padmaswari, Abbey L. Stokes, Daniel Maxenberger, Morgan Reese, Adila Khalil and Christopher E. Nelson
Biomedicines 2024, 12(6), 1226; https://doi.org/10.3390/biomedicines12061226 (registering DOI) - 31 May 2024
Abstract
The CRISPR-Cas9 system is a revolutionary tool in genetic engineering, offering unprecedented precision and efficiency in genome editing. Cas9, an enzyme derived from bacteria, is guided by RNA to edit DNA sequences within cells precisely. However, while CRISPR-Cas9 presents notable benefits and encouraging [...] Read more.
The CRISPR-Cas9 system is a revolutionary tool in genetic engineering, offering unprecedented precision and efficiency in genome editing. Cas9, an enzyme derived from bacteria, is guided by RNA to edit DNA sequences within cells precisely. However, while CRISPR-Cas9 presents notable benefits and encouraging outcomes as a molecular tool and a potential therapeutic agent, the process of producing and purifying recombinant Cas9 protein remains a formidable hurdle. In this study, we systematically investigated the expression of recombinant SpCas9-His in four distinct Escherichia coli (E. coli) strains (Rosetta2, BL21(DE3), BL21(DE3)-pLysS, and BL21(DE3)-Star). Through optimization of culture conditions, including temperature and post-induction time, the BL21(DE3)-pLysS strain demonstrated efficient SpCas9 protein expression. This study also presents a detailed protocol for the purification of recombinant SpCas9, along with detailed troubleshooting tips. Results indicate successful SpCas9 protein expression using E. coli BL21(DE3)-pLysS at 0.5 mM IPTG concentration. Furthermore, the findings suggest potential avenues for further enhancements, paving the way for large-scale Cas9 production. This research contributes valuable insights into optimizing E. coli strains and culture conditions for enhanced Cas9 expression, offering a step forward in the development of efficient genome editing tools and therapeutic proteins. Full article
(This article belongs to the Special Issue Protein Purification)
Show Figures

Figure 1

12 pages, 2423 KiB  
Article
Automated Quantification of Raster Orientation of Fused Filament Fabrication Components Using Ultrasonic Testing
by Atik Amin, David A. Jack and Trevor J. Fleck
Appl. Sci. 2024, 14(11), 4769; https://doi.org/10.3390/app14114769 (registering DOI) - 31 May 2024
Abstract
An automated method for nondestructively characterizing the layer-by-layer raster orientation of additively manufactured components fabricated via the fused filament fabrication (FFF) process is presented, which utilizes full waveform capture of the ultrasonic signal paired with two-dimensional fast Fourier transform analysis. The proposed method [...] Read more.
An automated method for nondestructively characterizing the layer-by-layer raster orientation of additively manufactured components fabricated via the fused filament fabrication (FFF) process is presented, which utilizes full waveform capture of the ultrasonic signal paired with two-dimensional fast Fourier transform analysis. The proposed method extracts internal features of the fabricated component at various depths and then applies the two-dimensional Fourier transformation in the spatial domain to analyze the raster path and extract the orientation. Three material systems are studied: a standard polymer (Poly cyclohexylenedimethylene terephthalate glycol, PCTG), an engineered polymer (high-temperature nylon, HTN) and a carbon fiber-filled polymer (polyethylene terephthalate, PET-CF). Samples were fabricated using an industrial-grade FFF system and scanned using a high-resolution custom immersion ultrasonic platform. Studies were performed using both a 10 MHz and a 15 MHz spherically focused transducer, with the 10 MHz transducer yielding more accurate and more consistent results for the investigated material systems. The analyzed results show that the presented automated method can accurately identify the direction of the raster path with an error within 1°–2° in each of the first 9~10 deposited layers of the investigated PCTG and the PET-CF samples, and the first 14 layers of the HTN samples. This study provides an approach for the automated analysis of the internal features of FFF components using ultrasonic testing, which can further inform the quality control process, in turn increasing reliability and enabling acceptance of AM parts in various industries. Full article
(This article belongs to the Special Issue Advanced Manufacturing and Nondestructive Testing Techniques)
Show Figures

Figure 1

14 pages, 2368 KiB  
Review
Can Tumour Antigens Act as Biomarkers for the Early Detection of Non-Small Cell Lung Cancer?
by Eithar Mohamed, Daniel Fletcher, Simon Hart and Barbara-ann Guinn
Onco 2024, 4(2), 87-100; https://doi.org/10.3390/onco4020008 (registering DOI) - 31 May 2024
Abstract
Lung cancer (LC) is one of the leading causes of cancer-related deaths. Pulmonary nodules are one of the risk factors, and their discovery rate has been increasing due to enhanced performance of chest CT scans, but more than 90% are non-malignant, causing unnecessary [...] Read more.
Lung cancer (LC) is one of the leading causes of cancer-related deaths. Pulmonary nodules are one of the risk factors, and their discovery rate has been increasing due to enhanced performance of chest CT scans, but more than 90% are non-malignant, causing unnecessary stress to patients and costs to healthcare providers. Early diagnosis of LC is associated with a 5-year survival rate of up to 75% following surgical resection, but LC is often diagnosed late due to a lack of symptoms and poor 5-year survival rates as low as 10%. The cost of LC diagnosis is high, with 40% of it associated with benign lesions, which are difficult to differentiate from malignant lesions. Tumour-associated antigens (TAAs) may provide one way in which LC could be diagnosed early using minimally-invasive techniques, under their association with immune responses and specificity for disease. Here we discuss the potential of cancer-testis antigens (CTAs) to act as non-invasive biomarkers for the early detection of non-small cell lung cancer. Full article
(This article belongs to the Special Issue Progress in Vaccination against Cancer - 2023 (PIVAC-23))
Show Figures

Graphical abstract

17 pages, 2879 KiB  
Article
Prediction Accuracy of Soil Chemical Parameters by Field- and Laboratory-Obtained vis-NIR Spectra after External Parameter Orthogonalization
by Konrad Metzger, Frank Liebisch, Juan M. Herrera, Thomas Guillaume and Luca Bragazza
Sensors 2024, 24(11), 3556; https://doi.org/10.3390/s24113556 (registering DOI) - 31 May 2024
Abstract
One challenge in predicting soil parameters using in situ visible and near infrared spectroscopy is the distortion of the spectra due to soil moisture. External parameter orthogonalization (EPO) is a mathematical method to remove unwanted variability from spectra. We created two different EPO [...] Read more.
One challenge in predicting soil parameters using in situ visible and near infrared spectroscopy is the distortion of the spectra due to soil moisture. External parameter orthogonalization (EPO) is a mathematical method to remove unwanted variability from spectra. We created two different EPO correction matrices based on the difference between spectra collected in situ and, respectively, spectra collected from the same soil samples after drying and sieving and after drying, sieving and finely grinding. Spectra from 134 soil samples recorded with two different spectrometers were split into calibration and validation sets and the two EPO corrections were applied. Clay, organic carbon and total nitrogen content were predicted by partial least squares regression for uncorrected and EPO-corrected spectra using models based on the same type of spectra (“within domain”) as well as using laboratory-based models to predict in situ collected spectra (“cross-domain”). Our results show that the within-domain prediction of clay is improved with EPO corrections only for the research grade spectrometer, with no improvement for the other parameters. For the cross-domain predictions, there was a positive effect from both EPO corrections on all parameters. Overall, we also found that in situ collected spectra provided an equally successful prediction as laboratory-based spectra. Full article
(This article belongs to the Special Issue Precision Agriculture and Sensor Systems—2nd Edition)
Show Figures

Figure 1

9 pages, 852 KiB  
Article
Optical Quasi-Periodic Oscillation of Blazar PKS 1440-389 in the TESS Light Curve
by He Lu, Tingfeng Yi, Yanke Tang, Junjie Wang, Shun Zhang, Liang Wang, Yutong Chen, Yuncai Shen, Liang Dong and Yangwei Zhang
Universe 2024, 10(6), 242; https://doi.org/10.3390/universe10060242 (registering DOI) - 31 May 2024
Abstract
We report the results of time series analysis of blazar PKS 1440-389, observed by the Transiting Exoplanet Survey Satellite (TESS) in two sectors. We find that the source has a quasi-periodic oscillation (QPO) of about 3.1 days for sector 11 and around 3.7 [...] Read more.
We report the results of time series analysis of blazar PKS 1440-389, observed by the Transiting Exoplanet Survey Satellite (TESS) in two sectors. We find that the source has a quasi-periodic oscillation (QPO) of about 3.1 days for sector 11 and around 3.7 days for sector 38 in the optical band. We use two methods to assess the QPO and its confidence level: Lomb–Scargle periodogram and weighted wavelet Z-transforms. We explore various potential explanations for these rapid quasi-periodic variations and propose that their source most likely resides within the innermost region of the accretion disk. Within this framework, we estimate the mass of the central black hole of this blazar. We obtain black hole masses of 6.65 × 108M (Schwarzschild black hole) and 4.22 × 109M (maximally rotating Kerr black hole), with a main period of 3.7 days. Finally, we utilize the kink instability model to explain the QPO. Full article
(This article belongs to the Special Issue Blazar Bursts: Theory and Observation)
Show Figures

Figure 1

26 pages, 9324 KiB  
Article
Architectural Framework to Enhance Image-Based Vehicle Positioning for Advanced Functionalities
by Iosif-Alin Beti, Paul-Corneliu Herghelegiu and Constantin-Florin Caruntu
Information 2024, 15(6), 323; https://doi.org/10.3390/info15060323 (registering DOI) - 31 May 2024
Abstract
The growing number of vehicles on the roads has resulted in several challenges, including increased accident rates, fuel consumption, pollution, travel time, and driving stress. However, recent advancements in intelligent vehicle technologies, such as sensors and communication networks, have the potential to revolutionize [...] Read more.
The growing number of vehicles on the roads has resulted in several challenges, including increased accident rates, fuel consumption, pollution, travel time, and driving stress. However, recent advancements in intelligent vehicle technologies, such as sensors and communication networks, have the potential to revolutionize road traffic and address these challenges. In particular, the concept of platooning for autonomous vehicles, where they travel in groups at high speeds with minimal distances between them, has been proposed to enhance the efficiency of road traffic. To achieve this, it is essential to determine the precise position of vehicles relative to each other. Global positioning system (GPS) devices have an intended positioning error that might increase due to various conditions, e.g., the number of available satellites, nearby buildings, trees, driving into tunnels, etc., making it difficult to compute the exact relative position between two vehicles. To address this challenge, this paper proposes a new architectural framework to improve positioning accuracy using images captured by onboard cameras. It presents a novel algorithm and performance results for vehicle positioning based on GPS and video data. This approach is decentralized, meaning that each vehicle has its own camera and computing unit and communicates with nearby vehicles. Full article
Show Figures

Figure 1

Open Access Journals

Browse by Indexing Browse by Subject Selected Journals
Back to TopTop