Thiourea and its derivatives have become a significant focal point within the organic synthesis field, garnering attention for their diverse biological applications, including antibacterial, antioxidant, anticancer, anti-inflammatory, anti-Alzheimer, antituberculosis and antimalarial properties. My objective is to present a comprehensive and easily understandable analysis of recent advancements in the organic synthesis of thiourea derivatives. My focus is on the structure and activity of these derivatives over the past five years, highlighting the significant progress made in the field of organic synthesis. Additionally, I evaluate the current state of research in this area and provide an overview of the latest trends and future prospects. This review will prove to be beneficial for researchers, academics and industry professionals involved in drug development and organic synthesis. Full article

There is a myriad of diseases that plague the world ranging from infectious, cancer and other chronic diseases with varying interventions. However, the dynamism of causative agents of infectious diseases and incessant mutations accompanying other forms of chronic diseases like cancer, have worsened the treatment outcomes. These factors often lead to treatment failure via different drug resistance mechanisms. More so, the cost of developing newer drugs is huge. This underscores the need for a paradigm shift in the drug delivery approach in order to achieve desired treatment outcomes. There is intensified research in nanomedicine, which has shown promises in improving the therapeutic outcome of drugs at preclinical stages with increased efficacy and reduced toxicity. Regardless of the huge benefits of nanotechnology in drug delivery, challenges such as regulatory approval, scalability, cost implication and potential toxicity must be addressed via streamlining of regulatory hurdles and increased research funding. In conclusion, the idea of nanotechnology in drug delivery holds immense promise for optimizing therapeutic outcomes. This work presents opportunities to revolutionize treatment strategies, providing expert opinions on translating the huge amount of research in nanomedicine into clinical benefits for patients with resistant infections and cancer. Full article

Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition characterized by persistent respiratory symptoms and airflow limitation. While there are some available treatment options, the effectiveness of treatment varies depending on individual differences and the phenotypes of the disease. Therefore, exploring or identifying potential therapeutic targets for COPD is urgently needed. In recent years, there has been growing evidence showing that lysophospholipids, namely lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), can play a significant role in the pathogenesis of COPD. Exploring the metabolism of lysophospholipids holds promise for understanding the underlying mechanism of COPD development and developing novel strategies for COPD treatment. This review primarily concentrates on the involvement and signaling pathways of LPC and LPA in the development and progression of COPD. Furthermore, we reviewed their associations with clinical manifestations, phenotypes, and prognosis within the COPD context and discussed the potential of the pivotal signaling molecules as viable therapeutic targets for COPD treatment. Full article

Human activities and climate change have profound impacts on the ecological environment of oases in Xinjiang, and it is of great significance to explore the spatial and temporal evolution patterns of ecological environment quality in this region for the sustainable development of Xinjiang. The remote sensing ecological index (RSEI) was extracted from the Google Earth Engine (GEE) platform from 2000 to 2020, and the coefficient of variation and Hurst index were used to reveal the spatial and temporal characteristics and stability of the ecological environment quality of the artificial oasis and natural oasis in Xinjiang. The key factors affecting the ecological environment quality are explored through correlation analysis and geoprobes. The results show that the distribution of the ecological environment in Xinjiang oases is high in the north and low in the south, and the overall quality shows a fluctuating downward trend from 0.210 to 0.189. Artificial oases have higher RSEI values, stability, and sustainability than natural oases. The RSEI in the study area was mainly influenced by humidity, followed by greenness and heat, and dryness had the least influence on the RSEI model. Based on the geodetector, the top three highest contributors were found to be precipitation (PRE) (0.83) > relative humidity (RHU) (0.82) > evapotranspiration (ET) (0.57). Climate is the main factor affecting the ecological quality of oases, and the RSEI can be improved by increasing the proportion of artificial oases. The study aims to provide a scientific basis for the sustainable development of oases in arid zones. Full article

Conservation Translocation (CT), which includes reintroduction, reinforcement and introduction, is gaining momentum, responding to serious population decline in many orchids. Orchid conservation underpinned by a greater emphasis on understanding biotic and abiotic factors of habitats is critical for successful recovery and restoration programmes. Anacamptis morio, commonly known as green-winged orchid (GWO), is a terrestrial orchid found throughout Europe, but populations in England rapidly declined in its native range in the last several decades. The current study explored the relationship between soil abiotic characteristics and the community composition of key fungal groups. Wild sites in Essex and Cumbria in England, where successful colonies are currently present, were compared to potential sites for CT in Cumbria. The Cumbrian sites managed by cattle grazing include the wild site and three potential CT sites, with two of them hosting no GWO plants. The Essex site, fOxley Meadow, where no cattle is used for grassland management, hosts the largest population of GWO in England. The aim of this study was to understand whether the community composition of fungi and soil characteristics of the potential CT sites in Cumbria are nearly compatible with that of Oxley Meadow. Oxley Meadow, with around 65,000 plants, stands out as a unique habitat compared to all Cumbria sites, as it showed low organic content. Nitrate and phosphate content were smaller for Oxley Meadow compared to other Cumbrian sites. The proportion of Basidiomycota fungi was greater in Oxley Meadow compared to all Cumbrian sites where Ascomycota dominated. The abundant fungal group found in Oxley Meadow was Agaricales. From Agariclaes, Hygrophoraceae or waxcaps fungi are considered an indicator group of fungi and were the most abundant group in Oxley Meadow. They have a negative correlation with targeted key fungal groups and abiotic parameters. More in-depth assessments using additional primers are essential to better understand the fungal diversity and how this diversity translates to the resilience of orchid habitats. This preliminary study points to future studies to assess whether sites are near-compatible to the wild site where large colonies are present using additional primers collected over different time scales. Full article

Recent research on attitudes to Australian English (AusE) shows that there is a general increase in its acceptance, legitimacy, and endonormativity. However, a certain “cultural cringe” exists, particularly when “broad” AusE is seen as representative of the variety. A significant gap in the literature is how the perceptions and usage of AusE may change as the population becomes more diverse. This paper presents findings of an online survey of language attitudes towards AusE with 661 respondents across Australia, over a third of whom were born overseas. Overall, there is minimal evidence of a standard language ideology, with 80% of respondents reporting having an accent to some degree. Almost half of respondents report occasionally or frequently changing their accents due to context, interlocutor, or making themselves understood. When asked to rate AusE along six traits on a seven-point scale, the traits of educatedness, professionalism, and attractiveness were consistently centered on neutral. For friendliness and likeability, the majority skewed towards neutral and positive. For the trait of clarity, there was a greater range of responses, but overall, 50% of respondents found AusE to be somewhat, moderately, or really clear. These findings further our understanding of attitudes and ideologies in Australia’s increasingly diverse language ecology. Full article

Ultra-high-performance concrete (UHPC) is considered to be a promising material for the strengthening of damaged reinforced concrete (RC) members due to its high mechanical strength and low permeability. However, its high material cost, limited code provisions, and scattered material properties limit its wide application. There is a great need to review existing articles and create a database to assist different technical committees for future code provisions on UHPC. This study presents a comprehensive overview focusing on the effect of the UHPC layer on the flexural and shear strengthening of RC beams. From this review, it was evident that (1) different retrofitting configurations have a remarkable effect on the cracking moment compared to the maximum moment in the case of flexural strengthening; (2) the ratios of the shear span and UHPC layer thickness have a notable effect on shear strengthening and the failure mode; and (3) different bonding techniques have insignificant effects on shear strengthening but a positive impact on flexural strengthening. Overall, it can be concluded that three-side strengthening has a higher increment range for flexural (maximum, 81%–120%; cracking, 300%–500%) and shear (maximum, 51%–80%; cracking, 121%–180%) strengthening. From this literature review, an experimental database was established, and different failure modes were identified. Finally, this research highlights current issues with UHPC and recommends some future works. Full article

What is truth? We have entered another period fraught with Gospel confusion—beyond postmodernism to what can be called “post-Christianity”. This is not unusual—so we should not be overwhelmed. This happens periodically, as early as Gal 1:9: “If anybody is preaching to you a gospel other than what you accepted, let him be eternally condemned”. It is all a question of the Gospel, or put another way, evangelism (the communication or announcing “the good news of God”). Evangelism is proclaiming and living a distinct message of Jesus Christ. Jesus is Himself the embodiment of the “good news”. The Gospel has been challenged, eroded and corrupted over the centuries—yet rediscovered by those who practice exegesis of the Biblical record of the New Testament. This article moves on to look at how secular philosophy—rather than Christian philosophy—and other “forms of the truth” have influenced the current situation we find ourselves in. Full article

The tumor suppressor gene F-box and WD repeat domain-containing (FBXW) 7 reduces cancer stemness properties by promoting the protein degradation of pluripotent stem cell markers. We recently demonstrated the transcriptional repression of FBXW7 by the three-dimensional (3D) spheroid formation of several cancer cells. In the present study, we found that the transcriptional activity of FBXW7 was promoted by the inhibition of the Ca²⁺-activated K⁺ channel, K_Ca1.1, in a 3D spheroid model of human prostate cancer LNCaP cells through the Akt-Nrf2 signaling pathway. The transcriptional activity of FBXW7 was reduced by the siRNA-mediated inhibition of the CCAAT-enhancer-binding protein C/EBP δ (CEBPD) after the transfection of miR223 mimics in the LNCaP spheroid model, suggesting the transcriptional regulation of FBXW7 through the Akt-Nrf2-CEBPD-miR223 transcriptional axis in the LNCaP spheroid model. Furthermore, the K_Ca1.1 inhibition-induced activation of FBXW7 reduced (1) K_Ca1.1 activity and protein levels in the plasma membrane and (2) the protein level of the cancer stem cell (CSC) markers, c-Myc, which is a molecule degraded by FBXW7, in the LNCaP spheroid model, indicating that K_Ca1.1 inhibition-induced FBXW7 activation suppressed CSC conversion in K_Ca1.1-positive cancer cells. Full article

In this paper, an approach is proposed for assessing the performance of experts in the group from two perspectives: (1) individual consistencies and (2) deviations from the group decision. The quality of performance of the experts is based on combining the standard and rough analytic hierarchy process (AHP) with the technique for order of preference by similarity to the ideal solution (TOPSIS). The statistical method CRITIC is used to derive weights for the TOPSIS method before the experts are assessed based on demonstrated consistency and deviations from the group. Common performance indicators, such as consistency ratio, Euclidean distance, compatibility, and Spearman’s correlation coefficient, are proposed for re-grouping experts before making the final decisions. A genetic algorithm enables the efficient solving of this complex clustering problem. Implementing the described approach and method can be useful in comparable assessment frameworks. A critical aspect is conducting a thorough pre-assessment of the competence of potential decision makers, often referred to as experts who may not consistently exhibit apparent expertise. The competence of decision makers (which does not have to be associated with compatibility) is evidenced by selected consistency parameters, and in a way, a pre-assessment of their competence follows Plato’s ‘government of the wise’ principle. In the presented study, the compatibility of individuals in the group with the collective position (group decision) is measured by parameters related to their compatibility with the group solution and statistical deviation while ranking decision elements. The proposed multi-model-based approach stands out for its resilience in conducting thorough pre-assessment of the quality (competence) of potential decision makers, often regarded as experts who might not consistently display evident expertise. The wetland study area in Serbia is used as an example application, where seven measures for reducing the risk of drought were evaluated by twelve experts coming from different sectors and with different backgrounds and expertise. Full article

Background: Improving local antibiotic delivery is a promising approach to improve infection control and potentially shorten systemic treatment in periprosthetic joint infection (PJI). This study investigates the use of an antibiotic-loaded, mouldable collagen–tricalciumphosphate composite in treatment of hip PJI. Methods: 124 application cases in 79 patients were included from a referral centre; systemic adverse infects, local complications, and infection control were analysed. Results: In most cases, either vancomycin or meropenem were used. Pathogens were previously known in 82 (66%) cases with polymicrobial infection in 20 (25%) patients. There were no cases of hypercalcaemia. Acute kidney injure was present in 14 (11%) cases. Chronic kidney failure persisted in two cases. During a mean follow-up of 12 (SD 9.3; range 3–35) months, implant survival was achieved in 73 (92%) patients; revision due to PJI was performed in 19 cases. Conclusion: Mouldable collagen–tricalciumphosphate composite bone substitute as a local antibiotic carrier in revision hip arthroplasty appears to be a valid option for local antibiotic delivery without systemic complications. Implant survival of 92% supports the hypothesis that local antibiotic therapy is an important component in the treatment of PJI. Full article

Growing concerns over gambling problems across age groups have sparked research in public health and psychology. During emerging adulthood, individuals are more susceptible to mental health problems and more likely to develop gambling problems than in other age groups. This study explored the potential differences between emerging adults and adults aged 30+ in terms of problem gambling severity (PGS), gambling-related harm (GRH), depression and anxiety, and the mediating role of depression and anxiety in the association between age, PGS, and GRH. A representative online sample of 3244 Israelis aged 18 and over was divided into two groups: 740 emerging adults aged 18–29 and 2504 adults aged 30+. Gambling behaviors, the Problem Gambling Severity Index, the Short Gambling Harm Screen, and the Patient Health Questionnaire-4 assessing depression and anxiety were administered. Emerging adults had significantly higher levels of GRH, PGS, and depression-anxiety than their older counterparts, above and beyond gender and education. Depression-anxiety fully mediated the associations between age and gambling-related outcomes. These findings underscore the importance of considering psychological well-being in efforts to address problem gambling and gambling-related harms, especially in emerging adults. Full article

The centrality of amyloid-beta (Aβ) is an indisputable tenet of Alzheimer’s disease (AD). It was initially indicated by the detection (1991) of a mutation within Aβ protein precursor (AβPP) segregating with the disease, which served as a basis for the long-standing Amyloid Cascade Hypothesis (ACH) theory of AD. In the intervening three decades, this notion was affirmed and substantiated by the discovery of numerous AD-causing and AD-protective mutations with all, without an exception, affecting the structure, production, and intraneuronal degradation of Aβ. The ACH postulated that the disease is caused and driven by extracellular Aβ. When it became clear that this is not the case, and the ACH was largely discredited, a new theory of AD, dubbed ACH2.0 to re-emphasize the centrality of Aβ, was formulated. In the ACH2.0, AD is caused by physiologically accumulated intraneuronal Aβ (iAβ) derived from AβPP. Upon reaching the critical threshold, it triggers activation of the autonomous AβPP-independent iAβ generation pathway; its output is retained intraneuronally and drives the AD pathology. The bridge between iAβ derived from AβPP and that generated independently of AβPP is the neuronal integrated stress response (ISR) elicited by the former. The ISR severely suppresses cellular protein synthesis; concurrently, it activates the production of a small subset of proteins, which apparently includes components necessary for operation of the AβPP-independent iAβ generation pathway that are absent under regular circumstances. The above sequence of events defines “conventional” AD, which is both caused and driven by differentially derived iAβ. Since the ISR can be elicited by a multitude of stressors, the logic of the ACH2.0 mandates that another class of AD, referred to as “unconventional”, has to occur. Unconventional AD is defined as a disease where a stressor distinct from AβPP-derived iAβ elicits the neuronal ISR. Thus, the essence of both, conventional and unconventional, forms of AD is one and the same, namely autonomous, self-sustainable, AβPP-independent production of iAβ. What distinguishes them is the manner of activation of this pathway, i.e., the mode of causation of the disease. In unconventional AD, processes occurring at locations as distant from and seemingly as unrelated to the brain as, say, the knee can potentially trigger the disease. The present study asserts that these processes include traumatic brain injury (TBI), chronic traumatic encephalopathy, viral and bacterial infections, and a wide array of inflammatory conditions. It considers the pathways which are common to all these occurrences and culminate in the elicitation of the neuronal ISR, analyzes the dynamics of conventional versus unconventional AD, shows how the former can morph into the latter, explains how a single TBI can hasten the occurrence of AD and why it takes multiple TBIs to trigger the disease, and proposes the appropriate therapeutic strategies. It posits that yet another class of unconventional AD may occur where the autonomous AβPP-independent iAβ production pathway is initiated by an ISR-unrelated activator, and consolidates the above notions in a theory of AD, designated ACH2.0/E (for expanded ACH2.0), which incorporates the ACH2.0 as its special case and retains the centrality of iAβ produced independently of AβPP as the driving agent of the disease. Full article

Background: Immune checkpoint blockade (ICB) has presented a breakthrough in the treatment of malignant tumors and increased the overall survival of patients with various tumor entities. ICB may also cause immune-related adverse events, such as pneumonitis or interstitial lung disease. The lung clearance index (LCI) is a multiple-breath washout technique offering information on lung pathology in addition to conventional spirometry. It measures the degree of pulmonary ventilation inhomogeneity and allows early detection of pulmonary damage, especially that to peripheral airways. Methods: This cross-sectional study compared the lung function of patients with melanoma or metastatic cutaneous squamous cell carcinoma who received programmed cell death 1 (PD-1) and cytotoxic T-Lymphocyte-associated Protein 4 (CTLA-4) antibodies, alone or in combination, to age- and sex-matched controls. Lung function was assessed using spirometry, according to American Thoracic Society and European Respiratory Society standards, the LCI, and a diffusion capacity of carbon monoxide (DLCO) measurement. Results: Sixty-one screened patients and thirty-eight screened controls led to nineteen successfully included pairs. The LCI in the ICB-treated patients was 8.41 ± 1.15 (mean ± SD), which was 0.32 higher compared to 8.07 ± 1.17 in the control group, but the difference was not significant (p = 0.452). The patients receiving their ICB therapy for under five months showed a significantly lower LCI (7.98 ± 0.77) compared to the ICB patients undergoing therapy for over five months (9.63 ± 1.22) at the point of testing (p = 0.014). Spirometric analysis revealed that the forced expiratory volume between 25 and 75% of the forced vital capacity (FEF25-75%) in the ICB-treated patients was significantly reduced (p = 0.047) compared to the control group. DLCO (%predicted and adjusted for hemoglobin) was 94.4 ± 19.7 in the ICB patients and 93.4 ± 21.7 in the control group (p = 0.734). Conclusions: The patients undergoing ICB therapy showed slightly impaired lung function compared to the controls. Longer periods of ICB treatment led to deterioration of the LCI, which may be a sign of a subclinical inflammatory process. The LCI is feasible and may be easily integrated into the clinical daily routine and could contribute to early detection of pulmonary (auto-)inflammation. Full article

Migmatites and partial melts are exposed in both the lower and upper package of the Higher Himalayan Crystallines (HHC) thrust sheet within the Sikkim Himalayas. Zircon monazite and quartz oxygen isotopic ratios from Yumthang Valley, North Sikkim, and Rathong Chuu, West Sikkim, have been used to identify their sources and equilibrium conditions. Monazites show homogeneous growth, whereas zircons show growth rings. U-Th-Pb data on monazite only indicate the latest metamorphic event. However, zircons show metamorphic rim growth between 36 and 24 Ma over their detrital core with trailing growth from 22 Ma to 15 Ma. Pervasive fluids have been interpreted in coeval development during metamorphism, as shown by monazite and zircon c. 30 Ma. The Th/U ratio of zircon is higher and variable with weak residual zoning in the samples from higher elevations. Quartz–metamorphic zircon oxygen fractionation suggests Teq > 600 °C, while quartz–monazite fractionation shows the same or lower temperatures. Multiple sources of melts in the HHC (even along a single valley) have been observed by δ¹⁸O of 7‰ to 10‰ in zircon and 5‰ to 9‰ in monazite. Zircon and monazite generated in the same rock have similar δ18O values. Monazite grown ~20 Ma in the lower elevation sample had a low δ¹⁸O, suggesting interaction with an external fluid. Full article

Background and Objectives: Hepatocellular carcinoma (HCC) is a prevalent form of malignancy that is characterized by high mortality rates and prognosis that remain suboptimal, largely due to treatment resistance mechanisms. Recent studies have implicated cancer stem cells (CSCs), particularly those expressing epithelial cell adhesion molecule (EpCAM), in HCC progression and resistance. In the present study, we sought to assess EpCAM expression in HCC patients and its correlation with various clinicopathological parameters. Materials and Methods: Tissue samples from 42 HCC patients were subjected to immunohistochemical staining to evaluate EpCAM expression. Clinicopathological data were obtained including the size, grade and stage of tumors, vascular invasion status, alpha-fetoprotein levels, and cirrhosis status. The Chi square and Fisher’s exact tests were employed to assess the association between categorical groups. Independent Student-t test or Mann–Whitney U test was used to investigate the association between continuous patient characteristics and survival. Results: Immunohistochemical analysis revealed EpCAM expression in 52.5% of HCC cases. EpCAM-positive tumors exhibited characteristics indicative of aggressive disease, including larger tumor sizes (p = 0.006), greater tumor multiplicity (p = 0.004), higher grades (p = 0.002), more advanced stages (p = 0.003), vascular invasion (p = 0.023), elevated alpha-fetoprotein levels (p = 0.013), and cirrhosis (p=0.052). Survival analysis demonstrated that EpCAM expression was significantly associated with lower overall rates of survival and higher rates of recurrence in HCC patients. Conclusions: Our findings suggest that EpCAM expression may serve as a prognostic biomarker for HCC with a potential role in patient management. Targeting EpCAM-positive CSCs may represent a promising approach to overcome treatment resistance and improve clinical outcomes in HCC. However, further investigation into the molecular mechanisms underlying EpCAM’s role in HCC progression is warranted to facilitate the development of personalized therapeutic interventions. Full article

In addressing the challenges of quantitative precipitation estimation (QPE) using weather radar, the importance of enhancing the rainfall estimates for applications such as flash flood forecasting and hydropower generation management is recognized. This study employed dual-polarization weather radar data to refine the traditional Z–R relationship, which often needs higher accuracy in areas with complex meteorological phenomena. Utilizing tree-based machine learning algorithms, such as random forest and gradient boosting, this research analyzed polarimetric variables to capture the intricate patterns within the Z–R relationship. The results highlight machine learning’s potential to improve the precision of precipitation estimation, especially under challenging weather conditions. Integrating meteorological insights with advanced machine learning techniques is a remarkable achievement toward a more precise and adaptable precipitation estimation method. Full article

Blueberry fruit phenotypes are crucial agronomic trait indicators in blueberry breeding, and the number of fruits within the cluster, maturity, and compactness are important for evaluating blueberry harvesting methods and yield. However, the existing instance segmentation model cannot extract all these features. And due to the complex field environment and aggregated growth of blueberry fruits, the model is difficult to meet the demand for accurate segmentation and automatic phenotype extraction in the field environment. To solve the above problems, a high-precision phenotype extraction model based on hybrid task cascade (HTC) is proposed in this paper. ConvNeXt is used as the backbone network, and three Mask RCNN networks are cascaded to construct the model, rich feature learning through multi-scale training, and customized algorithms for phenotype extraction combined with contour detection techniques. Accurate segmentation of blueberry fruits and automatic extraction of fruit number, ripeness, and compactness under severe occlusion were successfully realized. Following experimental validation, the average precision for both bounding boxes (bbox) and masks stood at 0.974 and 0.975, respectively, with an intersection over union (IOU) threshold of 0.5. The linear regression of the extracted value of the fruit number against the true value showed that the coefficient of determination (R²) was 0.902, and the root mean squared error (RMSE) was 1.556. This confirms the effectiveness of the proposed model. It provides a new option for more efficient and accurate phenotypic extraction of blueberry clusters. Full article

New U-Pb zircon ages are reported for granulite facies crustal xenoliths brought to the surface by mafic lavas in the Snake River Plain. All samples yield Meso-to-Neoarchean ages (2.4–3.6 Ga) that significantly expand the known extent of the Archean Wyoming Craton at least as far west as the west-central Snake River Plain. Most zircon populations indicate multiple growth episodes with complexity increasing eastward, but they bear no record of major Phanerozoic magmatic episodes in the region. To extrapolate this work further west to the inferred craton boundary, zircons from southwestern Idaho batholith granodiorites were also analyzed. Although most batholith zircons record Cretaceous formation ages, all samples have zircons with inherited cores—with some recording Proterozoic ages (approaching 2 Ga). These data enhance our perspectives regarding lithosphere architecture beneath southern Idaho and adjacent areas and its possible influence on Cenozoic magmatism associated with the Snake River Plain–Yellowstone “melting anomaly”. Full article

Functional traits are pivotal for understanding the functional niche within plant communities. Yet, the relationship between the functional niches of typical forest plant communities across different climatic zones, as defined by functional traits, and their association with community and phylogenetic structures remains elusive. In this study, we examined 215 woody species, incorporating 11 functional traits spanning leaf economy, mechanical support, and reproductive phenology, gathered from forests in four climatic zones from tropical, subtropical, warm-temperate to cold-temperate zones in China and supplemented by the literature. We quantified the functional niche hypervolume (FNH), reflecting the multidimensional functional niche variability. We then probed into the correlation between the FNH and community and phylogenetic structures of forests. Our findings reveal that species richness significantly influences the geographic variance of functional niche space in forest vegetation across different climatic zones. Specifically, a community’s species richness correlates positively with the functional niche breadth occupied by the community species. The FNH of woody plants across diverse forest types shows significant associations with both the mean phylogenetic distance (MPD) and the mean nearest phylogenetic taxon distance (MNTD) of the communities. There is a progressive increase in tropical rainforest (TF), subtropical evergreen deciduous broad-leaved mixed forest (SF), and warm-temperate coniferous broad-leaved mixed forest (WF), followed by a decline in the cold-temperate coniferous forest (CF). This pattern suggests potential environmental filtering in CF, which may constrain the spatial extent of plant functional niches. Our research underscores the substantial variability in the FNH across China’s typical forest vegetation, highlighting the complex interplay between functional traits, community richness, and phylogenetic distance. Full article