Abstract
THE molecular mechanism of mitosis in higher eukaryotic cells is largely unknown. Here, we state briefly some aspects of the mitotic mechanism that are well characterised, add information derived from our recent investigations, and offer a new model of mitotic movement based on intrinsic microtubule behaviour. We propose that two events, poleward-sliding of anti-parallel microtubules and an opposite end assembly/disassembly of all microtubules, occur constantly throughout mitosis and act coordinately to produce mitotic movement.
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MARGOLIS, R., WILSON, L. & KIEFER, B. Mitotic mechanism based on intrinsic microtubule behaviour. Nature 272, 450–452 (1978). https://doi.org/10.1038/272450a0
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DOI: https://doi.org/10.1038/272450a0
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