Abstract
THE stimulatory action of vitamin D on intestinal calcium absorption has been much studied following the pioneering work of Nicolaysen1 and several important features of the mechanism are fairly well established2. Doubt concerning the chemical identity of the biologically active form of vitamin D has arisen, however, leading to extensive investigations of this aspect3–5. Two important proposals arose out of this work; first, vitamin D3 (cholecalciferol) must be first converted to 1,25-dihydroxycholecalciferol (1,25-diOH-CC) (ref. 6) before it can act on the intestine; and second, 1,25-diOH-CC stimulates intestinal calcium transport directly by an actinomycin D-insensitive process6.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Nicolaysen, R., Biochem. J., 31, 122 (1937).
Wasserman, R. H., and Taylor, A. N., in Mineral Metabolism, An Advanced Treatise (edit. by Comar, C. L., and Bronner, F.), 3, 321 (Academic Press, NY, 1969).
Lawson, D. E. M., Fraser, D. R., Kodicek, E., Morris, H. R., and Williams, D. H., Nature, 230, 228 (1971).
Holick, M. F., Schnoes, H. K., and DeLuca, H. F., Proc. US Nat. Acad. Sci., 68, 803 (1971).
Norman, A. W., Myrtle, J. F., Midgett, R. J., and Nowicki, H. G., Science, 173, 51 (1971).
Tanaka, Y., DeLuca, H. F., and Holick, M. F., Proc. US Nat. Acad. Sci., 68, 1286 (1971).
Corradino, R. A., and Wasserman, R. H., Science, 172, 731 (1971).
Corradino, R. A., Science, 179, 402 (1973).
Corradino, R. A., and Wasserman, R. H., Biophys. Soc. Absts., 11, 276a (1971).
Corradino, R. A., J. Cell. Biol. (in the press).
Reich, E., and Goldberg, I. H., Progr. Nucleic Acid Res. Mol. Biol., 3, 183 (1964).
Haussler, M. R., and Norman, A. W., Proc. US Nat. Acad. Sci., 62, 155 (1969).
Cousins, R. J., DeLuca, H. F., Suda, T., Chen, T., and Tanaka, Y., Biochemistry, 9, 1453 (1970).
Hallick, R. B., and DeLuca, H. F., Proc. US Nat. Acad. Sci., 63, 528 (1969).
Norman, A. W., Biochem. Biophys. Res. Commun., 23, 335 (1966).
Stohs, S. J., Zull, J. E., and DeLuca, H. F., Biochemistry, 6, 1304 (1967).
Zull, J. E., Czarnowska-Misztal, E., and DeLuca, H. F., Science, 149, 183 (1965).
Norman, A. W., Amer. J. Physiol., 211, 829 (1966).
MacGregor, R. R., Hamilton, J. W., and Cohn, D. B., Clin. Orthopaed. Related Res., 78, 83 (1971).
Taylor, A. N., and Wasserman, R. H., Fed. Proc., 28, 1834 (1969).
Corradino, R. A., and Wasserman, R. H., Arch. Biochem. Biophys., 126, 957 (1968).
Corradino, R. A., and Wasserman, R. H., Fed. Proc., 31, 686 (1972).
Corradino, R. A., Ebel, J. G., Craig, P. H., Taylor, A. N., and Wasserman, R. H., Calc. Tiss. Res., 7, 81 (1971).
Wieland, T., Science, 159, 946 (1968).
Lindell, T. J., Weinberg, F., Morris, P. W., Roeder, R. G., and Rutter, W. J., Science, 170, 447 (1970).
Kedinger, C., Gniazdowski, M., Mandel, jun., J. C., Gissinger, F., and Chambon, P., Biochem. Biophys. Res. Commun., 38, 165 (1970).
Incefy, G., and Kappas, A., FEBS Lett., 15, 153 (1971).
Sekeris, C. E., Niessing, J., and Seifact, K. H., FEBS Lett., 9, 103 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CORRADINO, R. 1,25-Dihydroxycholecalciferol: Inhibition of Action in Organ-cultured Intestine by Actinomycin D and α-Amanitin. Nature 243, 41–43 (1973). https://doi.org/10.1038/243041a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/243041a0
This article is cited by
-
Effect of cortisol on [3H] 1,25-dihydroxyvitamin D3 uptake and 1,25-dihydroxyvitamin D3-induced DNA-dependent RNA polymerase activity in chick intestinal cells
Calcified Tissue International (1987)
-
The metabolism and mechanism of action of 1,25-dihydroxyvitamin D3
Kidney International (1986)
-
Characterization of 1,25-dihydroxyvitamin D3-dependent calcium uptake in isolated chick duodenal cells
The Journal of Membrane Biology (1986)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
